Results 1 to 10 of about 530,867 (277)

IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations [PDF]

Mediators of Inflammation, 2015
It has been known that activation of the central innate immune system or exposure to stress can disrupt balance of anti-/proinflammatory cytokines. The aim of the present study was to investigate the role of pro- and anti-inflammatory cytokines in the ...
Hyun-Jung Park, Hyun-Soo Shim, Kyungeh An, Angela Starkweather, Kyung Soo Kim, Insop Shim   +5 more
doaj   +5 more sources

Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction.

PLoS ONE, 2023
Interleukin-1β (IL-1β) is one of the most potent pro-inflammatory cytokines implicated in a wide range of autoinflammatory, autoimmune, infectious, and degenerative diseases.
Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun, Hyun Sik Na, Keun-Hyung Cho, Seok Jung Kim, Mi-La Cho, Tae-Hwe Heo   +8 more
doaj   +2 more sources

Serum IL–1β, IL–2, IL–6, and IL–8 levels in schizophrenia subtypes

Psychiatry and Clinical Psychopharmacology, 2021
Objective: The cytokines are considered to be an important topic in immunological studies of schizophrenia. In this clinical study IL-1β, IL-2, IL-6, and IL-8 levels were compared among schizophrenia subtypes and a control group.
Murat Kuloglu, Yılmaz Bayik, Ahmet Unal, Omer Gecici, Bilal Ustundag   +4 more
doaj   +1 more source

Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts.

PLoS ONE, 2021
In autoimmune diseases, fibroblasts produce and secrete various cytokines and act as sentinel immune cells during inflammatory states. However, the contribution of sentinel immune cells (i.e.
Atsuto Naruke, Rei Nakano, Junichi Nunomura, Yoko Suwabe, Masumi Nakano, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama   +9 more
doaj   +2 more sources

Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β [PDF]

, 2015
The Notch1 and Notch4 signaling pathways regulate endothelial cell homeostasis. Inflammatory cytokines induce the expression of endothelial adhesion molecules, including VCAM1, partly by downregulating Notch4 signaling.
Adesso, Laura, Alisi, Anna, Campese, Antonio Francesco, Ciarapica, Roberta, Giorda, Ezio, Gueguen, Marie, Kitajewski, Jan, Limon, Isabelle, Locatelli, Franco, Miele, Lucio, Panera, Nadia, Raimondi, Lavinia, Rota, Rossella, Screpanti, Isabella, Stifani, Stefano, Verginelli, Federica   +15 more
core   +6 more sources

IL-1β is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1β autostimulation. [PDF]

PLoS ONE, 2012
Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1β-driven neuroinflammation in the pathogenesis of diabetic retinopathy.
Yang Liu, Montserrat Biarnés Costa, Chiara Gerhardinger   +2 more
doaj   +1 more source

In Silico Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface

Molecules, 2023
IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases.
Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi, Fahad M. Alshabrmi, Mamdouh Allahyani, Ahad Amer Alsaiari, Pei Liu, Muhammad Raheel Khan, Qinghua Peng   +9 more
doaj   +1 more source

Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. [PDF]

, 2014
Inflammatory response and cell death in hepatocytes are hallmarks of chronic liver disease, and, therefore, can be effective therapeutic targets. Neurotropin® (NTP) is a drug widely used in Japan and China to treat chronic pain.
Liang, Shuang, Liu, Cheng, Masuda, Koichi, Naiki, Mitsuru, Roh, Yoon Seok, Seki, Ekihiro, Zhang, Bi   +6 more
core   +7 more sources

Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging [PDF]

, 2020
Microglia express constitutively a Nox2 enzyme that is involved in neuroinflammation by the generation of reactive oxygen species (ROS). Amyloid β (Aβ) plays a crucial role in Alzheimer’s disease.
Fan, Lampson M., Geng, Li, Li, Jian-mei, Liu, Fangfei, Smith, Colin   +4 more
core   +2 more sources

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +2 more sources