Results 11 to 20 of about 6,778,674 (329)

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Nature Communications, 2023
The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1.
Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux, Gabriella Dow, Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng, Shijie Wang, Daniel J. Bennison, Rebecca Morrison, Avinash R. Shenoy   +13 more
doaj   +2 more sources

Lesió i protecció de les cèl·lules beta en el trasplantament d'illots pancreàtics [PDF]

, 2007
[cat] El trasplantament d'illots pancreàtics pot ser una bona teràpia per els malalts amb diabetis mellitus de tipus 1, però hi ha alguns problemes que cal solventar abans que sigui un tractament estès.
Montolio Rusiñol, Marta
core   +6 more sources

IL-1β promotes immunoregulatory responses in human blood basophils. [PDF]

, 2021
Human basophils are essential effector cells of chronic allergic inflammation. IL-1 family cytokines such as interleukin (IL)-33 and IL-1β are elevated in serum and bronchoalveolar lavage fluid of allergic asthmatics.
Fux, Michaela, Sofia Bachmann, Joseena Iype, Iype, Joseena, Bachmann, Sofia, Andrea Odermatt, Mazarine Coeudevez, Michaela Fux, Odermatt, Andrea, Coeudevez, Mazarine   +9 more
core   +1 more source

The emerging role of Interleukin 1β (IL-1β) in cancer cachexia [PDF]

, 2021
Treatment of cancer cachexia remains an unmet need. The host-tumour interface and the resulting sequestration of the pro-inflammatory cytokine Il-1β is critical in cachexia development.
Laird, Barry J, McMillan, Donald, Gallagher, Iain J, Skipworth, Richard JE, Paval, D Robert, Skipworth, Richard, Skipworth, Richard J E, Laird, Barry J A, McNeish, I., Gallagher, Iain, Paval, Robert, McNeish, Iain, Fallon, Marie T   +12 more
core   +1 more source

The role of IL-1β and TNF-α in intervertebral disc degeneration.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. IDD is mainly caused by aging, trauma,
Yongjie Wang, Ming-Xue Che, Jingguo Xin, Zhi Zheng, Jiang-Bin Li, Shao-Kun Zhang   +5 more
semanticscholar   +1 more source

Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy

Journal of Cachexia, Sarcopenia and Muscle, 2021
Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome, compromises cardiac function.
Katharina Busch, Melanie Kny, Nora Huang, Tilman E. Klassert, Magdalena Stock, Alexander Hahn, S. Graeger, M. Todiras, S. Schmidt, B. Chamling, M. Willenbrock, Stefan Gross, D. Biedenweg, A. Heuser, C. Scheidereit, C. Butter, S. Felix, O. Otto, F. Luft, H. Slevogt, J. Fielitz   +20 more
semanticscholar   +1 more source

In Silico Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface

Molecules, 2023
IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases.
Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi, Fahad M. Alshabrmi, Mamdouh Allahyani, Ahad Amer Alsaiari, Pei Liu, Muhammad Raheel Khan, Qinghua Peng   +9 more
doaj   +1 more source

Succinate is a danger signal that induces IL-1β via HIF-1α

Nature, 2013
Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis.
G. Tannahill, Anne M. Curtis, Juraj Adamik, E. Pålsson-McDermott, A. F. Mcgettrick, G. Goel, C. Frezza, N. Bernard, B. Kelly, N. Foley, Liang Zheng, A. Gardet, Z. Tong, S. Jany, S. Corr, M. Haneklaus, BE Caffery, K. Pierce, S. Walmsley, F. Beasley, E. Cummins, V. Nizet, M. Whyte, C. Taylor, Hening Lin, S. Masters, E. Gottlieb, V. Kelly, C. Clish, P. Auron, R. Xavier, L. O'Neill   +31 more
semanticscholar   +1 more source

Inflammatory cytokines TNFα, IL-1β, and IL-6 are induced in endotoxin- stimulated microglia through different signaling cascades

Science in progress, 2021
By using an animal model in which inflammatory cytokines are induced in lipopolysaccharide (LPS)-injected rat brain, we investigated the induction of tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β), and IL-6.
Takashi Ishijima, K. Nakajima
semanticscholar   +1 more source

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Nature Medicine, 2009
The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T lymphocytes.
F. Ghiringhelli, L. Apetoh, A. Tesnière, L. Aymeric, Yuting Ma, Carla Ortiz, K. Vermaelen, T. Panaretakis, G. Mignot, E. Ullrich, J. Perfettini, F. Schlemmer, E. Tasdemir, M. Uhl, P. Génin, A. Civas, B. Ryffel, J. Kanellopoulos, J. Tschopp, F. André, R. Lidereau, N. McLaughlin, N. Haynes, M. Smyth, G. Kroemer, L. Zitvogel   +25 more
semanticscholar   +1 more source