Results 41 to 50 of about 4,734,962 (279)
A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages [PDF]
Frontiers in Microbiology, 2015 Vibrio fluvialis causes human diarrhea, but the pathogenesis is not well-studied. We hypothesized that V. fluvialis-secreted hemolysin (VFH) may induce IL-1β secretion through the activation of the NLRP3 inflammasome and contribute to the pathogenicity of V. fluvialis.
Song, Liqiong +9 more
openaire +3 more sources
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
Genes differentially expressed between IL-1β and ctrl, COT IL-1β and IL-1β, COT and ctrl conditions.
, 2016 Genes differentially expressed between IL-1β and ctrl, COT IL-1β and IL-1β, COT and ctrl conditions.
Samuel Serisier (554865) +6 more
core +1 more source
ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions [PDF]
Frontiers in Immunology, 2015 Interleukin-1β is a potent proinflammatory cytokine, of which processing and secretion are tightly regulated. After exposure to various stimuli, mononuclear phagocytes synthesize the inactive precursor (pro-IL-1β), which is then cleaved intracellularly by caspase-1 and secreted.
Monique eStoffels +11 more
openaire +5 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
, 2017 Cells isolated from lesions or PBMC obtained from L. braziliensis patients were stained for flow cytometry directly ex vivo and depicted are (a) IL-1β+ CD11b+ cells (b) IL-1β expression within CD68+ (macrophages and monocytes) or CD66b+ (granulocytes) in
Daniel P. Beiting (434631) +7 more
core +1 more source
Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β [PDF]
, 2017 There is a strong link between integrins and interleukin-1β (IL-1β), but the specifics of the role of integrins in IL-1β signaling are unclear. We describe that IL-1β specifically bound to integrins αvβ3 and α5β1.
Yu, Jessica +11 more
core +1 more source
Non-canonical Inflammasome-Mediated IL-1β Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent [PDF]
Frontiers in Immunology, 2019 Inflammation of the post-partum uterus is a normal physiological event, crucial for tissue involution and repair. However, in the bovine, some cows fail to resolve this inflammation, resulting in endometritis, which compromises fertility. Earlier work has identified upregulated expression of the potent inflammatory cytokine IL-1β early post-partum, in ...
Paul Kelly +4 more
openaire +6 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad +9 more
wiley +1 more source
IL-1β affected the expression of PAPP-A mRNA.
, 2023 The increased IL-1β mRNA expression level was observed in model group, which was significantly reduced in IL-1β knockdown group (A). The PAPP-A mRNA expression level was observed in model group, which was significantly downregulated by the IL-1β ...
Rui Min (4039946) +6 more
core +1 more source