Results 41 to 50 of about 3,308,702 (244)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
The Correlation b etween IL - 1β and IL - 10 Levels in Estimating t he Risk of Febrile Seizures
Journal of Tropical Life Science, 2014 Febrile seizures are the most-common form of seizures in children with fever and evidence from clinical and experimental studies suggests the potential role of immune generated products in their genesis.
Gunawan A +4 more
doaj
Neurología (English Edition), 2017 Background: Interleukin-1β (IL-1β) increases necrotic neuronal cell death in the CA1 area after induced status epilepticus (SE) in developing rats. However, it remains uncertain whether IL-1β has a similar effect on the hippocampal dentate gyrus (DG). In
C. Rincón-López +5 more
doaj +1 more source
Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats
Pharmaceuticals, 2021 Sickness behavior, characterized by on overall reduction in behavioral activity, is commonly observed after bacterial infection. Sickness behavior can also be induced by the peripheral administration of Gram-negative bacterial lipopolysaccharide (LPS) or
Léa Chaskiel +2 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Pro-IL-1β is expressed at similar levels in ArpC2 Flox and iKO cells.
, 2023 Mouse fibroblasts were treated with DMSO (Flox) or 4-OHT (iKO) for 6d and collected at 9d. Samples were lysed, subjected to SDS-PAGE, and immunoblotted with antibodies to IL-1β, tubulin, actin, and GAPDH. Pro-IL-1β densitometry values are shown.
Shirley Guo (14515841) +4 more
core +1 more source
Species-specific IL-1β is an inflammatory sensor of Seneca Valley Virus 3C Protease.
PLoS PathogensInflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved in the maturation of IL-1β and IL-18, while human caspase-4 specifically processes IL-18.
Xiangyu Huang +12 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2018 Concentrations of IL-1β (average and range) present in supernatants of Al(OH)3 or DTaP-stimulated THP-1 cells in the absence or presence of Glybenclamide. Data are from three individual experiments, with two technical replicates.
Jeroen L. A. Pennings (224558) +9 more
core +1 more source
Neurología, 2017 Resumen: Introducción: La interleucina 1β (IL-1β) aumenta la muerte neuronal necrótica debido al estado epiléptico (EE) en el área CA1 del hipocampo de ratas en desarrollo; sin embargo, se desconoce si ejerce un efecto similar en el giro dentado (GD ...
C. Rincón-López +5 more
doaj +1 more source