Results 21 to 30 of about 3,308,702 (244)
Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion
eLife, 2015 Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells.
Min Zhang +4 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2001 Previously, our laboratory showed that interleukin-1β (IL-1β) secreted by lipopolysaccharide-activated monocytes induces promatrilysin expression in the prostate carcinoma cell line, LNCaP.
Mimi Suzanne Maliner-Stratton +4 more
doaj +1 more source
Trimeric form of intracellular ATP synthase subunit β of Aggregatibacter actinomycetemcomitans binds human interleukin-1β. [PDF]
PLoS ONE, 2011 Bacterial biofilms resist host defenses and antibiotics partly because of their decreased metabolism. Some bacteria use proinflammatory cytokines, such as interleukin (IL)-1β, as cues to promote biofilm formation and to alter virulence.
Annamari Paino +9 more
doaj +1 more source
Scientific Reports, 2023 Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging.
Dániel Kucsera +11 more
doaj +1 more source
, 2016 (A) Gene expression profiling identified Mmp7 as one of the top up-regulated gene in Asc-/- and Nlrp3-/- mice with bladder pathology (CFT073 infected mice, 7 days). Log2 fold change of Mmp7 expression levels in individual mice are shown relative to the H&
Björn Wullt (243099) +10 more
core +1 more source
Journal of Neuroinflammation, 2019 Background Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but the related mechanisms remain vague.
Yi Sun +9 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm +11 more
wiley +1 more source
HPV16 oncoproteins inhibit pro-IL-1β levels.
, 2018 (A) Human keratinocytes transduced with pLXSN or 16E6E7 were stimulated with AIM2 and (B) NLPR3 ligands and both pro-IL-1β and IL-1β from cell lysates or supernatants were analysed by immunoblotting. β-actin was used as a loading control.
Claudia Zannetti (199411) +21 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási +14 more
wiley +1 more source
IL-1β and IL-17 rewire naïve SFs to a CIA-like phenotype.
, 2021 (A) Global methylation status of Naïve-SFs incubated in medium alone (Naïve) or chronically treated with IL-17 or IL-1β, compared to that of CIA-SFs. Data (means ± SEM) are from 3–5 independent experiments, normalized to “Naïve” controls.
Felicity E. Lumb (8566887) +9 more
core +1 more source