Results 21 to 30 of about 6,778,674 (329)

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

Nature Communications, 2020
Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1β ...
Mausita Karmakar, Martin S Minns, Elyse Greenberg, Jose Diaz-Aponte, K. Pestonjamasp, J. Johnson, Joseph K. Rathkey, Derek W. Abbott, Kun Wang, F. Shao, S. Catz, G. Dubyak, E. Pearlman   +12 more
semanticscholar   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D/bioreactor model [PDF]

, 2013
IntroductionThe present study examined the effect of C-type natriuretic peptide (CNP) and biomechanical signals on anabolic and catabolic activities in chondrocyte/agarose constructs.MethodsNatriuretic peptide (Npr) 2 and 3 expression were compared in ...
Salter, Donald M, Salter, Donald M., Ramachandran, Manoj, Adrian J Hobbs, Hobbs, Adrian J., Ramachandran, M, Moyes, AJ, Amie J Moyes, Peake, Nicholas, Bader, Dan L, Bader, DL, Chowdhury, Tina T., Donald M Salter, Pramod Achan, Bader, Dan L., Peake, N, Su, N, Achan, P, Hobbs, AJ, Salter, DM, Nyan Su, Achan, Pramod, Nicholas Peake, Chowdhury, TT, Moyes, Amie J., Dan L Bader, Tina T Chowdhury, Su, Nyan, Chowdhury, Tina T, Hobbs, Adrian J, Moyes, Amie J, Manoj Ramachandran   +31 more
core   +1 more source

IL-1β-induced activation of ERK1/2.

, 2021
(a, b) Time-dependent changes of ERK1/2 phosphorylation. Western blotting for the levels of phosphorylated ERK1/2 (p-ERK1/2) and total ERK1/2 (t-ERK1/2) in dermal fibroblasts treated with IL-1β (100 pM) (a) and relative levels of [p-ERK1/2]/[t-ERK1/2] in
Taku Kitanaka (3350276), Tomohiro Nakayama (30894), Nanako Kitanaka (3350285), Masumi Nakano (11648962), Atsuto Naruke (11648956), Hiroshi Sugiya (412101), Rei Nakano (820735), Junichi Nunomura (11648959), Yoko Suwabe (9468965), Shinichi Namba (3350288)   +9 more
core   +1 more source

Platelet-Rich Fibrin Reduces IL-1β Release from Macrophages Undergoing Pyroptosis [PDF]

, 2022
Background: Pyroptosis is a catabolic process relevant to periodontal disorders for which interleukin-1β (IL-1β) inflammation is central to the pathophysiology of the disease.
Gruber, Reinhard, Reinhard Gruber, Panahipour, Layla, Sordi, Mariane Beatriz, Zahra Kargarpour, Kargarpour, Zahra, Mariane Beatriz Sordi, Layla Panahipour   +7 more
core   +2 more sources

Newcastle disease virus RNA-induced IL-1β expression via the NLRP3/caspase-1 inflammasome

Veterinary Research, 2020
Newcastle disease virus (NDV) infection causes severe inflammation and is a highly contagious disease in poultry. Virulent NDV strains (GM) induce large quantities of interleukin-1β (IL-1β), which is the central mediator of the inflammatory reaction ...
Pei Gao, Libin Chen, Lei Fan, Jinlian Ren, Haoyun Du, Minhua Sun, Yaling Li, Peng Xie, Qiuyan Lin, Ming Liao, Chenggang Xu, Zhangyong Ning, Chan Ding, Bin Xiang, Tao Ren   +14 more
doaj   +1 more source

Activation of Autophagy by Inflammatory Signals Limits IL-1β Production by Targeting Ubiquitinated Inflammasomes for Destruction

Nature Immunology, 2012
Autophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18 ...
Chong Shi, K. Shenderov, Ning Huang, J. Kabat, M. Abu-Asab, K. Fitzgerald, A. Sher, J. Kehrl   +7 more
semanticscholar   +1 more source

MOLECULAR BIOLOGY ANALYSIS OF IL -1Β, IL -4, AND IL -1Β RA GENE POLYMORPHISMS IN ETHNIC BASHKIR PATIENTS WITH RHEUMATOID ARTHRITIS, LIVING IN C HELYABINSK REGION

Медицинская иммунология, 2014
. Common polymorphisms of interleukin-1β, receptor antagonist interleukin-1, and interleukin-4 genes have been studied among the patients with rheumatoid arthritis of Bashkir origin, living in Chelyabinsk Region.
A. L. Burmistrova, D. S. Stashkevich, T. A. Susslova, I. V. Devald, A. O. Issakanova, O. N. Dimcheva   +5 more
doaj   +1 more source

Pyruvate Kinase M2 regulates Hif-1α activity and IL-1β induction, and is a critical determinant of the Warburg Effect in LPS-activated macrophages

Cell Metabolism, 2015
SUMMARY Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characterized
E. Pålsson-McDermott, Anne M. Curtis, G. Goel, M. Lauterbach, Frederick J. Sheedy, Laura E. Gleeson, Mirjam W. M. van den Bosch, Susan R. Quinn, R. Domingo-Fernández, Daniel GW Johnson, Jain-kang Jiang, William J. Israelsen, J. Keane, Craig J. Thomas, C. Clish, Matthew Vanden Heiden, R. Xavier, L. O'Neill   +17 more
semanticscholar   +1 more source

NKT Cells Join the Two Step for Inflammasome-Independent IL-1β Release

Cell Reports, 2020
The cytokine interleukin-1β (IL-1β) is critical for antimicrobial defenses; the inflammasome pathway typically controls IL-1β release, but pathogens often evade this pathway. In this issue, Donado et al. (2020) describe an alternative, two-cell model, to
Jelena S. Bezbradica, Sebastian Joyce
doaj   +1 more source

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Nature Communications, 2021
Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases.
S. Vijayaraj, R. Feltham, M. Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, G. Ebert, Angelina J. Vince, M. Herold, Andrew J Kueh, Jaclyn S. Pearson, L. Dagley, James M. Murphy, A. Webb, K. Lawlor, J. Vince   +15 more
semanticscholar   +1 more source