Results 21 to 30 of about 530,867 (277)

Betaine Inhibits Interleukin-1β Production and Release: Potential Mechanisms

Frontiers in Immunology, 2018
Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1β secretion; however, the underlying mechanisms by which betaine inhibits IL-1β secretion remain to be uncovered. In this review,
Yaoyao Xia, Yaoyao Xia, Yaoyao Xia, Shuai Chen, Shuai Chen, Guoqiang Zhu, Ruilin Huang, Yulong Yin, Yulong Yin, Yulong Yin, Wenkai Ren, Wenkai Ren   +11 more
doaj   +1 more source

Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils

Frontiers in Immunology, 2018
Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic reticulum-to-Golgi pathway, and for which a canonical mechanism of secretion remains to be established.
Leonardo Iula, Irene A. Keitelman, Florencia Sabbione, Federico Fuentes, Mauricio Guzman, Jeremías Gastón Galletti, Pehuén Pereyra Gerber, Matías Ostrowski, Jorge R. Geffner, Jorge R. Geffner, Carolina C. Jancic, Carolina C. Jancic, Analía S. Trevani, Analía S. Trevani   +13 more
doaj   +1 more source

Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]

, 2019
Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina, Duan, Xin, Pan, Hua, Pham, Christine T. N., Rai, Muhammad Farooq, Sandell, Linda J., Wickline, Samuel A., Yan, Huimin   +7 more
core   +3 more sources

Zinc depletion regulates the processing and secretion of IL-1β [PDF]

Cell Death & Disease, 2014
AbstractSterile inflammation contributes to many common and serious human diseases. The pro-inflammatory cytokine interleukin-1β (IL-1β) drives sterile inflammatory responses and is thus a very attractive therapeutic target. Activation of IL-1β in sterile diseases commonly requires an intracellular multi-protein complex called the NLRP3 (NACHT, LRR ...
Pedrosa Mendes, Pedro, Summersgill, H., England, H., Lopez-Castejon, G., Lawrence, C. B., Luheshi, N. M., Pahle, J., Mendes, P., Brough, D.   +8 more
openaire   +3 more sources

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

eLife, 2015
Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells.
Min Zhang, Samuel J Kenny, Liang Ge, Ke Xu, Randy Schekman   +4 more
doaj   +1 more source

Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy [PDF]

, 2017
BACKGROUND: Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis.
B Jonghe De, C Jin, C Langhans, C Winkelman, CA Dinarello, CA Dinarello, CA Dinarello, CA Dinarello, CA Salkowski, CF Bolton, D Constantin, D Rittirsch, D Yaffe, DP Cerretti, E Jean-Baptiste, F Martinon, F Schmidt, HM Blau, HW Hees van, J Bierbrauer, JG Cannon, JH Pruitt, JP Lefaucheur, JS Sullivan, K Niemi, K Schroder, K-A Cho, LA Callahan, LG LeMay, M Deuren van, M Hoene, M Klaude, M Lamkanfi, M Llovera, MS Herridge, N Yu, O Gross, R Brigelius-Flohé, R Rawat, RS Hotchkiss, S Afonina Inna, S Levine, S Weber-Carstens, SC Bodine, SH Lecker, SL Passey, T Wollersheim, T-D Kanneganti, TR Helliwell, W Li, ZA Puthucheary   +50 more
core   +6 more sources

Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]

, 1994
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Ertel, Wolfgang, Faist, Eugen, Jarrar, Doreid, Jochum, Marianne, Kenney, John, Schildberg, Friedrich-Wilhelm, Thiele, Volker   +6 more
core   +1 more source

Immunomodulatory Effect of Nigella sativa Extract through the Improvement of IL-1β Level in Balb-c Mice Infected by Methicillin-resistant Staphylococcus aureus

Jurnal Kedokteran Brawijaya, 2020
Nigella sativa (NS) has been used for many years as an anti-bacterial herbal treatment, such as Methicillin-resistant Staphylococcus aureus, but the mechanism in bacterial elimination is still unknown. IL-1β is a proinflammatory cytokine that helps the immune system eliminate microbes when it enters the body. The purpose of this study was to prove the
Galuh Yulieta Nitihapsari, Octavia Permata S, Miko Ferine   +2 more
openaire   +2 more sources

Interleukin-1β-Induced Promatrilysin Expression is Mediated by NFκB-Regulated Synthesis of Interleukin-6 in the Prostate Carcinoma Cell Line, LNCaP

Neoplasia: An International Journal for Oncology Research, 2001
Previously, our laboratory showed that interleukin-1β (IL-1β) secreted by lipopolysaccharide-activated monocytes induces promatrilysin expression in the prostate carcinoma cell line, LNCaP.
Mimi Suzanne Maliner-Stratton, Russell D. Klein, Thirupandiyur S. Udayakumar, Raymond B. Nagle, George Timothy Bowden   +4 more
doaj   +1 more source

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease [PDF]

, 2013
Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer but the processes that promote hepatic inflammation by HCV are not defined.
Bertoletti, Antonio, Crochet, Nanette, Delker, Don A., Doehle, Brian, Gale, Michael, Hagedorn, Curt H., Jo, Juandy, Lau, Daryl Tan-Yeung, Negash, Amina A., Papic, Neven, Ramos, Hilario J.   +10 more
core   +3 more sources