Results 21 to 30 of about 375,559 (237)

Evaluation of IL-1β and TNF-α expression and periodontitis under the influence of orthodontic appliances with minocycline

Cellular and Molecular Biology, 2020
The current experiment was carried out to observe and analyze the effects of three orthodontic appliances combined with minocycline on periodontitis and inflammatory factors of gingival crevicular fluid. the patients included in this study were 180 patients with dental crowding treated in our hospital.
Jingjing, Zhang, Suqing, Qi, Weican, Chen, Lin, Liu, Hongwei, Hui   +4 more
openaire   +3 more sources

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages [PDF]

Scientific Reports, 2019
AbstractInflammation and metabolism are intricately linked during inflammatory diseases in which activation of the nucleotide-binding domain–like receptors Family Pyrin Domain Containing 3 (NLRP3) inflammasome, an innate immune sensor, is critical.
Orla M. Finucane, Jamie Sugrue, Ana Rubio-Araiz, Marie-Victoire Guillot-Sestier, Marina A. Lynch   +4 more
openaire   +4 more sources

Trimeric form of intracellular ATP synthase subunit β of Aggregatibacter actinomycetemcomitans binds human interleukin-1β. [PDF]

PLoS ONE, 2011
Bacterial biofilms resist host defenses and antibiotics partly because of their decreased metabolism. Some bacteria use proinflammatory cytokines, such as interleukin (IL)-1β, as cues to promote biofilm formation and to alter virulence.
Annamari Paino, Heidi Tuominen, Mari Jääskeläinen, Jonna Alanko, Jari Nuutila, Sirkka E Asikainen, Lauri J Pelliniemi, Marja T Pöllänen, Casey Chen, Riikka Ihalin   +9 more
doaj   +1 more source

Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Journal of Neuroinflammation, 2019
Background Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but the related mechanisms remain vague.
Yi Sun, Jiangjun Ma, Dongfang Li, Pinggan Li, Xiaolin Zhou, Yu Li, Zhanwen He, Lijun Qin, Liyang Liang, Xiangyang Luo   +9 more
doaj   +1 more source

A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells [PDF]

Journal of Cellular and Molecular Medicine, 2009
AbstractThe histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has recently been shown to inhibit deleterious effects of cytokines on β‐cells, but it is unable to protect β‐cells from death due to its own cytotoxicity. Herein, we investigated novel HDAC inhibitors for their cytoprotective effects against IL‐1β‐induced damage to isolated β‐cells.
Laura, Susick, Thulani, Senanayake, Rajakrishnan, Veluthakal, Patrick M, Woster, Anjaneyulu, Kowluru   +4 more
openaire   +3 more sources

IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH

Scientific Reports, 2023
Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging.
Dániel Kucsera, Viktória E. Tóth, Nabil V. Sayour, Tamás Kovács, Tamás G. Gergely, Mihály Ruppert, Tamás Radovits, Alexandra Fábián, Attila Kovács, Béla Merkely, Péter Ferdinandy, Zoltán V. Varga   +11 more
doaj   +1 more source

Effects of interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α ) on dopamine of the cerebral palsy

Asian Journal of Tropical Biotechnology, 2004
The caused of disability on cerebral palsy is unknown, but the human cerebral hypoxic, which affected to the motor cortex and motor pathways in the brain is believed cause of it. The major clinical manifestations are abnormality of movements and posture patterns. The immunity against the cerebral palsy (CP) is unknown, but interleukine-1β (IL-1β) and
openaire   +1 more source

A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages [PDF]

Frontiers in Microbiology, 2015
Vibrio fluvialis causes human diarrhea, but the pathogenesis is not well-studied. We hypothesized that V. fluvialis-secreted hemolysin (VFH) may induce IL-1β secretion through the activation of the NLRP3 inflammasome and contribute to the pathogenicity of V. fluvialis.
Song, Liqiong, Huang, Yuanming, Zhao, Meng, Wang, Zhihao, Wang, Shujing, Sun, Hui, Kan, Biao, Meng, Guangxun, Liang, Weili, Ren, Zhihong   +9 more
openaire   +3 more sources

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance There is a growing understanding that inflammation impairs synaptic plasticity and cognition and that the aged brain has an elevated sensitivity to cognitive impairment by the proinflammatory cytokine interleukin 1β (IL-1β). IL-1β activates different pathways via AcP (proinflammatory) or AcPb (prosurvival) IL-1 receptor subunits.
Prieto, GA, Snigdha, S, Baglietto-Vargas, D, Smith, ED, Berchtold, NC, Tong, L, Ajami, D, Laferla, FM, Rebek, J, Cotman, CW   +9 more
openaire   +6 more sources

Long‐Term Outcomes of Patients With Relapsed/Refractory Neuroblastoma Treated on ANBL1221: A Report From the Children's Oncology Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Results of COG ANBL1221 changed treatment paradigms for patients with relapsed/refractory neuroblastoma. Chemoimmunotherapy with irinotecan/temozolomide/dinutuximab is now used as both bridge therapy following suboptimal response to induction and as treatment in first relapse.
Elizabeth Sokol, Arlene Naranjo, Lulu Chen, Rajen Mody, Steven G. DuBois, Rochelle Bagatell, Navin Pinto   +6 more
wiley   +1 more source