Results 31 to 40 of about 530,867 (277)

Modulation of human polymorphonuclear leukocyte chemotaxis and superoxide anion production byPseudomonas aeruginosaexoproducts, IL-1β and piroxicam [PDF]

FEMS Immunology & Medical Microbiology, 1995
Whereas addition of 200 ng ml-1 exotoxin A (exoA) did not modify PMNL chemotaxis, 20 U ml-1 human recombinant interleukin-1 beta (hrIL-1 beta) primed polymorphonuclear leukocytes (PMNL) for migration towards Pseudomonas aeruginosa peptide chemotactins (PAPCs).
P A, Fontán, C R, Amura, F R, Buzzola, D O, Sordelli   +3 more
openaire   +2 more sources

Trimeric form of intracellular ATP synthase subunit β of Aggregatibacter actinomycetemcomitans binds human interleukin-1β. [PDF]

PLoS ONE, 2011
Bacterial biofilms resist host defenses and antibiotics partly because of their decreased metabolism. Some bacteria use proinflammatory cytokines, such as interleukin (IL)-1β, as cues to promote biofilm formation and to alter virulence.
Annamari Paino, Heidi Tuominen, Mari Jääskeläinen, Jonna Alanko, Jari Nuutila, Sirkka E Asikainen, Lauri J Pelliniemi, Marja T Pöllänen, Casey Chen, Riikka Ihalin   +9 more
doaj   +1 more source

Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]

, 2017
Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario, Braghetta, Paola, Bressan, Giorgio M., Carnevale, Daniela, Carnevale, Lorenzo, Carnevale, Raimondo, Casaburo, Manuel, Cifelli, Giuseppe, DA ROS, Francesco, Fardella, Stefania, Iacobucci, Roberta, Lembo, Giuseppe, Perrotta, Marialuisa, Vinciguerra, Iolanda   +13 more
core   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin, AK Wann, AK Wann, AM Malone, AR Sartori-Cintra, BL Thoms, BL Thoms, CA Clement, CA Clement, CF Chang, CJ Haycraft, CJ Haycraft, CR Thoma, D Kong, D Zhu, DA Hoey, DM Katschinski, E Verghese, EN Pugacheva, F Oeffner, GJ Pazour, HA Praetorius, J Kim, JB Catterall, JC Kim, JE Bohonowych, JE Lafont, JF Reiter, JH Moyer, JH Ryu, JM Gerdes, JR Marszalek, JT Eggenschwiler, KC Corbit, KC Corbit, L Schneider, M Windheim, MA Lancaster, MF Bijlsma, NV Prodromou, P Jaakkola, PD Taulman, PV Tran, R Rohatgi, RD Thornton, S Abdul-Majeed, S Kim, S Massinen, S Murakami, S Proulx-Bonneau, S Yang, SH Low, SM Nauli, SN Greer, SR McGlashan, SR McGlashan, T Caspary, TY Besschetnova, X Xue, Y Li, YJ Jung   +60 more
core   +1 more source

A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells [PDF]

Journal of Cellular and Molecular Medicine, 2009
AbstractThe histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has recently been shown to inhibit deleterious effects of cytokines on β‐cells, but it is unable to protect β‐cells from death due to its own cytotoxicity. Herein, we investigated novel HDAC inhibitors for their cytoprotective effects against IL‐1β‐induced damage to isolated β‐cells.
Laura, Susick, Thulani, Senanayake, Rajakrishnan, Veluthakal, Patrick M, Woster, Anjaneyulu, Kowluru   +4 more
openaire   +3 more sources

IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH

Scientific Reports, 2023
Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging.
Dániel Kucsera, Viktória E. Tóth, Nabil V. Sayour, Tamás Kovács, Tamás G. Gergely, Mihály Ruppert, Tamás Radovits, Alexandra Fábián, Attila Kovács, Béla Merkely, Péter Ferdinandy, Zoltán V. Varga   +11 more
doaj   +1 more source

Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration. [PDF]

, 2011
International audienceThe pro-inflammatory cytokine IL-1β has been shown to promote angiogenesis. It can have a neurotoxic or neuroprotective effect. Here, we have studied the expression of IL-1β in vivo and the effect of the IL-1 receptor antagonist on ...
Behar-Cohen, Francine, Calippe, Bertrand, Camelo, Serge, Chemtob, Sylvain, Combadière, Christophe, Guillonneau, Xavier, Houssier, Marianne, Jonet, Laurent, Lavalette, Sophie, Levy, Olivier, Raoul, William, Sennlaub, Florian   +11 more
core   +5 more sources

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages [PDF]

Scientific Reports, 2019
AbstractInflammation and metabolism are intricately linked during inflammatory diseases in which activation of the nucleotide-binding domain–like receptors Family Pyrin Domain Containing 3 (NLRP3) inflammasome, an innate immune sensor, is critical.
Orla M. Finucane, Jamie Sugrue, Ana Rubio-Araiz, Marie-Victoire Guillot-Sestier, Marina A. Lynch   +4 more
openaire   +4 more sources

Evaluation of IL-1β and TNF-α expression and periodontitis under the influence of orthodontic appliances with minocycline

Cellular and Molecular Biology, 2020
The current experiment was carried out to observe and analyze the effects of three orthodontic appliances combined with minocycline on periodontitis and inflammatory factors of gingival crevicular fluid. the patients included in this study were 180 patients with dental crowding treated in our hospital.
Jingjing, Zhang, Suqing, Qi, Weican, Chen, Lin, Liu, Hongwei, Hui   +4 more
openaire   +3 more sources

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance There is a growing understanding that inflammation impairs synaptic plasticity and cognition and that the aged brain has an elevated sensitivity to cognitive impairment by the proinflammatory cytokine interleukin 1β (IL-1β). IL-1β activates different pathways via AcP (proinflammatory) or AcPb (prosurvival) IL-1 receptor subunits.
Prieto, GA, Snigdha, S, Baglietto-Vargas, D, Smith, ED, Berchtold, NC, Tong, L, Ajami, D, Laferla, FM, Rebek, J, Cotman, CW   +9 more
openaire   +6 more sources