Results 51 to 60 of about 6,778,674 (329)

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis

Frontiers in Immunology
Introduction Chronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in ...
Anna Tylutka, Ł. Walas, A. Zembroń-Lacny   +2 more
semanticscholar   +1 more source

Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

Bone Research, 2020
The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration (IVDD).
Fan Chen, Guowei Jiang, Hui Liu, Ze-Min Li, Yuxin Pei, Hua Wang, He-Hai Pan, Hao-Wen Cui, Jun Long, Jian-Ru Wang, Zhao-Min Zheng   +10 more
semanticscholar   +1 more source

Exploring the role of IL-1β in inflammatory bowel disease pathogenesis

Frontiers in Medicine
Interleukin 1β (IL-1β) is a significant mediator of inflammation and tissue damage in IBD. The balance between IL-1β and its endogenous inhibitor-IL-1Ra-, plays a critical role in both initiation and regulation of inflammation.
I. Aggeletopoulou, M. Kalafateli, E. Tsounis, C. Triantos   +3 more
semanticscholar   +1 more source

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

Scientific Reports, 2018
We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are ...
A. Ng, W. Tam, Melvyn W. B. Zhang, Cyrus S. H. Ho, S. F. Husain, R. McIntyre, R. Ho   +6 more
semanticscholar   +1 more source

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance There is a growing understanding that inflammation impairs synaptic plasticity and cognition and that the aged brain has an elevated sensitivity to cognitive impairment by the proinflammatory cytokine interleukin 1β (IL-1β).
Prieto, GA, Snigdha, S, Baglietto-Vargas, D, Smith, ED, Berchtold, NC, Tong, L, Ajami, D, Laferla, FM, Rebek, J, Cotman, CW   +9 more
openaire   +6 more sources

Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.

Journal of Clinical Investigation, 2020
Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with the release of IL-1β.
K. Bulek, Junjie Zhao, Yun Liao, N. Rana, D. Corridoni, A. Antanaviciute, Xing Chen, Han Wang, W. Qian, William A. Miller-Little, S. Swaidani, Fangqiang Tang, B. Willard, Keith McCrae, Zizhen Kang, G. Dubyak, F. Cominelli, A. Simmons, T. Pizarro, Xiao-Xia Li   +19 more
semanticscholar   +1 more source

Effects of interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α ) on dopamine of the cerebral palsy

Asian Journal of Tropical Biotechnology, 2004
The caused of disability on cerebral palsy is unknown, but the human cerebral hypoxic, which affected to the motor cortex and motor pathways in the brain is believed cause of it. The major clinical manifestations are abnormality of movements and posture patterns. The immunity against the cerebral palsy (CP) is unknown, but interleukine-1β (IL-1β) and
openaire   +1 more source

A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells [PDF]

Journal of Cellular and Molecular Medicine, 2009
AbstractThe histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has recently been shown to inhibit deleterious effects of cytokines on β‐cells, but it is unable to protect β‐cells from death due to its own cytotoxicity. Herein, we investigated novel HDAC inhibitors for their cytoprotective effects against IL‐1β‐induced damage to isolated β‐cells.
Laura, Susick, Thulani, Senanayake, Rajakrishnan, Veluthakal, Patrick M, Woster, Anjaneyulu, Kowluru   +4 more
openaire   +3 more sources

IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH

Scientific Reports, 2023
Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging.
Dániel Kucsera, Viktória E. Tóth, Nabil V. Sayour, Tamás Kovács, Tamás G. Gergely, Mihály Ruppert, Tamás Radovits, Alexandra Fábián, Attila Kovács, Béla Merkely, Péter Ferdinandy, Zoltán V. Varga   +11 more
doaj   +1 more source

Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Nature Immunology, 2010
Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 ...
S. Masters, A. Dunne, Shoba L. Subramanian, R. Hull, Gillian M. Tannahill, F. Sharp, Christine E. Becker, L. Franchi, E. Yoshihara, Zhe Chen, N. Mullooly, Lisa A. Mielke, J. Harris, Rebecca C. Coll, K. Mills, Hun K. Mok, P. Newsholme, G. Núñez, J. Yodoi, S. Kahn, Ed C. Lavelle, L. O'Neill   +21 more
semanticscholar   +1 more source