Results 71 to 80 of about 530,867 (277)
Neurología (English Edition), 2017 Background: Interleukin-1β (IL-1β) increases necrotic neuronal cell death in the CA1 area after induced status epilepticus (SE) in developing rats. However, it remains uncertain whether IL-1β has a similar effect on the hippocampal dentate gyrus (DG). In
C. Rincón-López +5 more
doaj +1 more source
Effect of Plectranthus Amboinicus Extract on BUN and Creatinine Levels and Cellular Response Proinflammatory Factors TNF-α and IL-1β on Gout Arthritis Patients [PDF]
, 2014 The purpose of this research was to develop anti-cytokine-based treatment using extract of Plectranthus amboinicus applied to gout arthritis (GA) patients. The research was quasi experimental, with a pretest-posttest randomized control group design.
Martini, S. (Santi) +3 more
core +2 more sources
, 2016 The expression of MMP-13 mRNA level increased in five OA patientsâ articular cartilage tissues. Quantitative reverse transcription-polymerase chain reaction analysis of the matrix metalloproteinase 13 (MMP-13) in articular cartilage tissues from five patients with OA. Figure S2.
Yujie Liang +8 more
openaire +1 more source
Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts
Journal of Pharmacological Sciences, 2017 Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome. To characterize the significance of the NLRP3 inflammasome pathway in the placenta, the effects of activators and inhibitors on NLRP3-related molecules were examined using ...
Kazuhiro Tamura +6 more
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Species-specific IL-1β is an inflammatory sensor of Seneca Valley Virus 3C Protease.
PLoS PathogensInflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved in the maturation of IL-1β and IL-18, while human caspase-4 specifically processes IL-18.
Xiangyu Huang +12 more
doaj +1 more source
The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]
, 2019 Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M. +7 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Neurología, 2017 Resumen: Introducción: La interleucina 1β (IL-1β) aumenta la muerte neuronal necrótica debido al estado epiléptico (EE) en el área CA1 del hipocampo de ratas en desarrollo; sin embargo, se desconoce si ejerce un efecto similar en el giro dentado (GD ...
C. Rincón-López +5 more
doaj +1 more source
Frontiers in Immunology, 2020 Helicobacter pylori is a gram-negative, microaerophilic, and spiral-shaped bacterium and causes gastrointestinal diseases in human. IL-1β is a representative cytokine produced in innate immune cells and is considered to be a key factor in the development
Ah-Ra Jang +12 more
doaj +1 more source