Results 81 to 90 of about 6,778,674 (329)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Correlation b etween IL - 1β and IL - 10 Levels in Estimating t he Risk of Febrile Seizures

Journal of Tropical Life Science, 2014
Febrile seizures are the most-common form of seizures in children with fever and evidence from clinical and experimental studies suggests the potential role of immune generated products in their genesis.
Gunawan A, Muid M, Sujuti H, Barlianto W, Subandiyah K   +4 more
doaj  

PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes[S]

Journal of Lipid Research, 2014
This study examined the role of interleukin (IL)-1 receptor-associated kinase (IRAK) and protein kinase C (PKC) in oxidized LDL (Ox-LDL)-induced monocyte IL-1β production.
Rajiv Lochan Tiwari, Vishal Singh, Ankita Singh, Minakshi Rana, Anupam Verma, Nikhil Kothari, Monica Kohli, Jaishri Bogra, Madhu Dikshit, Manoj Kumar Barthwal   +9 more
doaj   +1 more source

Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats

Pharmaceuticals, 2021
Sickness behavior, characterized by on overall reduction in behavioral activity, is commonly observed after bacterial infection. Sickness behavior can also be induced by the peripheral administration of Gram-negative bacterial lipopolysaccharide (LPS) or
Léa Chaskiel, Robert Dantzer, Jan Pieter Konsman   +2 more
doaj   +1 more source

WITHDRAWN: IFN-γ and IL-1β treated-human placenta-derived mesenchymal stromal cells enhance the generation of IL-10+T cells by upregulating PDLs expressions and ameliorate experimental autoimmune encephalomyelitis

Oncotarget, 2018
// Zhuoya Wang 1, * , Weiwei Wang 1, * , Yun Hou 2 , Aiping Zhang 1 , Guoyan Wang 3 , Junzhu Yi 1 , Qiang Fu 1 and Xiying Luan 1, 4 1 Department of Immunology, Binzhou Medical University, Shandong Province, Yantai 264003, People’s Republic of China 2 Department of Histology and Embryology, Binzhou Medical University, Shandong Province ...
Zhuoya Wang, Zhuoya Wang, Weiwei Wang, Weiwei Wang, Yun Hou, Yun Hou, Aiping Zhang, Aiping Zhang, Guoyan Wang, Guoyan Wang, Junzhu Yi, Junzhu Yi, Qiang Fu, Qiang Fu, Xiying Luan, Xiying Luan   +15 more
openaire   +1 more source

IL-1β and IL-17 rewire naïve SFs to a CIA-like phenotype.

, 2021
(A) Global methylation status of Naïve-SFs incubated in medium alone (Naïve) or chronically treated with IL-17 or IL-1β, compared to that of CIA-SFs. Data (means ± SEM) are from 3–5 independent experiments, normalized to “Naïve” controls.
Felicity E. Lumb (8566887), William Harnett (848414), Margaret M. Harnett (1304640), Sarah McGrath (11663424), Rinako Nakagawa (5830145), Miguel A. Pineda (8566893), Kun Yang (19445), Marlene Corbet (11663421), Anuradha Tarafdar (489798), Colin J. Suckling (1268478)   +9 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Species-specific IL-1β is an inflammatory sensor of Seneca Valley Virus 3C Protease.

PLoS Pathogens
Inflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved in the maturation of IL-1β and IL-18, while human caspase-4 specifically processes IL-18.
Xiangyu Huang, Zhenchao Zhao, Cheng Zhu, Lvye Chai, Ya Yan, Ye Yuan, Lei Wu, Minjie Li, Xiaohan Jiang, Haiwei Wang, Zheng Liu, Pingwei Li, Xin Li   +12 more
doaj   +1 more source

Interleukin-1β increases neuronal death in the hippocampal dentate gyrus associated with status epilepticus in the developing rat

Neurología (English Edition), 2017
Background: Interleukin-1β (IL-1β) increases necrotic neuronal cell death in the CA1 area after induced status epilepticus (SE) in developing rats. However, it remains uncertain whether IL-1β has a similar effect on the hippocampal dentate gyrus (DG). In
C. Rincón-López, A. Tlapa-Pale, J.-S. Medel-Matus, J. Martínez-Quiroz, J.F. Rodríguez-Landa, M.-L. López-Meraz   +5 more
doaj   +1 more source

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

Journal of Pharmacological Sciences, 2017
Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome. To characterize the significance of the NLRP3 inflammasome pathway in the placenta, the effects of activators and inhibitors on NLRP3-related molecules were examined using ...
Kazuhiro Tamura, Gen Ishikawa, Mikihiro Yoshie, Wakana Ohneda, Akihito Nakai, Toshiyuki Takeshita, Eiichi Tachikawa   +6 more
openaire   +3 more sources