Results 81 to 90 of about 3,308,702 (244)
Evolving concurrent Petri net models of epistasis
, 2010 A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core +1 more source
IL-1β regulated the expression of TNF-α, IL-6 and IL-8.
, 2023 The expression levels of TNF-α, IL-6 and IL-8 were significantly increased after CSE administration, which were downregulated upon IL-1β knockdown.
Rui Min (4039946) +6 more
core +1 more source
JACC: Basic to Translational Science, 2023 Mallory Filipp, MS, Edward B. Thorp, PhD
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
IFN-gamma impairs release of IL-8 by IL-1beta-stimulated A549 lung carcinoma cells [PDF]
, 2008 Background Production of interferon (IFN)-gamma is key to efficient anti-tumor immunity. The present study was set out to investigate effects of IFNgamma on the release of the potent pro-angiogenic mediator IL-8 by human A549 lung carcinoma cells ...
Bernhard Zwissler +15 more
core +1 more source
The GSDMD pores control the NSPs activity and consequently the pro-IL-1β processing or degradation.
, 2023 (A-D) Neutrophils were pretreated or not with DSF for 30 min, and then challenged with STEC at MOI 0.5 (A-E) and MOI 50 (A-C). Two hours later they were stained with the FAM-FLISP probe and the percentage of cells with active NSPs was determined by flow ...
Irene Angelica Keitelman (17692572) +15 more
core +1 more source
Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing
FEBS Open Bio, 2015 Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation.
Tadayoshi Karasawa +10 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Genes differentially expressed between IL-1β and ctrl, COT IL-1β and IL-1β, COT and ctrl conditions.
, 2016 Genes differentially expressed between IL-1β and ctrl, COT IL-1β and IL-1β, COT and ctrl conditions.
Samuel Serisier (554865) +6 more
core +1 more source