Results 91 to 100 of about 530,867 (277)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A balanced IL-1β activity is required for host response to Citrobacter rodentium infection. [PDF]

PLoS ONE, 2013
Microbial sensing plays essential roles in the innate immune response to pathogens. In particular, NLRP3 forms a multiprotein inflammasome complex responsible for the maturation of interleukin (IL)-1β.
Misagh Alipour, Yuefei Lou, Daniel Zimmerman, Michael W Bording-Jorgensen, Consolato Sergi, Julia J Liu, Eytan Wine   +6 more
doaj   +1 more source

Additional file 1: Table S1. of P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells

, 2018
Sequences of the primers used in this study. (DOC 32 kb)
Quan, Juan-Hua, Huang, Rui, Wang, Zhuang, Huang, Shuai, Choi, In-Wook, Zhou, Yu, Lee, Young-Ha, Chu, Jia-Qi   +7 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Serum amyloid A primes microglia for ATP-dependent interleukin-1\u3b2 release [PDF]

, 2018
Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA).
A Basu, A Franceschini, AA Culbert, AJ Sharp, AL Giuliani, AM Van Dam, B Sperlágh, C Gabay, C Marinelli, C Solà, C Volonté, CA Dinarello, CM Uhlar, D Ferrari, D Kim, DL Thiele, E Gruys, E Nishida, E Venereau, G Guillemin, G Ristori, H Yokote, I Hardardóttir, I Kushner, I Rajkovic, J Saura, JA Sloane, JS Liang, JT Guo, K Chang, K Niemi, K Selmaj, L Facci, L Facci, L Peferoen, L Probert, L Sun, L Yao, Laura Facci, LK Parvathenani, M Barbierato, M Barbierato, M Casula, M Connolly, M De Buck, M Idzko, M Li, M Sanz, Massimo Barbierato, ME Hamby, MK McCoy, Morena Zusso, MS Kindy, MT Heneka, N Chauvet, N Cheng, P Honore, Pietro Giusti, R Ebert, RA Dal Canto, RJ Rodrigues, S Kim, S Sandri, S Tanaka, SD Skaper, SD Skaper, SD Skaper, SJ Crocker, SJ Hewett, SL Passey, SM Allan, Stephen D. Skaper, SY Seong, T Kawamoto, T Miida, T Tamamoto, TF Chung, TH Holm, XQ Li, Y Kumon, Y Wang, Y Yu, YR Ji   +82 more
core   +2 more sources

Additional file 1: Figure S1. of Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

, 2017
Global gene expression patterns in hiChondrocytes and juvenile chondrocytes are distinct from adult chondrocytes: (a) scheme for a step-wise hiChondrocyte differentiation from hiPSC using defined growth factors, (b) cell proliferation kinetics of hiChondrocytes, adult chondrocytes, and juvenile chondrocytes over 24, 48, and 96 hours, (c)heatmap ...
Jieun Lee, Smeriglio, Piera, Chu, Constance, Bhutani, Nidhi   +3 more
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Interleukin-1β and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis.

PLoS ONE, 2013
BackgroundMultiple sclerosis (MS) has been mainly attributed to white matter (WM) pathology. However, recent evidence indicated the presence of grey matter (GM) lesions.
Marloes Prins, Charlotta Eriksson, Anne Wierinckx, John G J M Bol, Rob Binnekade, Fred J H Tilders, Anne-Marie Van Dam   +6 more
doaj   +1 more source

IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells. [PDF]

PLoS ONE, 2011
Earlier, we have shown that GM-CSF-exposed CD8α- DCs that express low levels of pro-inflammatory cytokines IL-12 and IL-1β can induce Foxp3+ Tregs leading to suppression of autoimmunity.
Balaji B Ganesh, Palash Bhattacharya, Anupama Gopisetty, Jianrong Sheng, Chenthamarakshan Vasu, Bellur S Prabhakar   +5 more
doaj   +1 more source

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. [PDF]

, 2014
IntroductionAcid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis.
Boyle, David L, Firestein, Gary S, Gong, Weiyi, Kolker, Sandra J, Sluka, Kathleen A, Usachev, Yuriy, Walder, Roxanne Y   +6 more
core   +2 more sources