Results 1 to 10 of about 28,282,310 (344)

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

eLife, 2017
The ubiquitin ligase TRAF6 is a key regulator of canonical IκB kinase (IKK)/NF-κB signaling in response to interleukin-1 (IL-1) stimulation. Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interactor of TRAF6 in human cells.
Gisela Schimmack, Kenji Schorpp, Kerstin Kutzner, Torben Gehring, Jara Kerstin Brenke, Kamyar Hadian, Daniel Krappmann   +6 more
doaj   +1 more source

Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation

Epigenetics, 2021
Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression. Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through direct
Matt J Barter, Kathleen Cheung, Julia Falk, Andreas C Panagiotopoulos, Caitlin Cosimini, Siobhan O’Brien, Karina Teja-Putri, Graham Neill, David J Deehan, David A. Young   +9 more
doaj   +1 more source

The P2X7 Receptor-Interleukin-1 Liaison

Frontiers in Pharmacology, 2017
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g., auto-inflammatory syndromes, as well as common pathologies ...
A. Giuliani, A. Sarti, S. Falzoni, F. Di Virgilio   +3 more
semanticscholar   +1 more source

Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease

Frontiers in Immunology, 2020
Cytokines activate or inhibit immune cell behavior and are thus integral to all immune responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream processes to affect both innate and adaptive immunity.
Katerina Pyrillou, Laura C. Burzynski, Murray C. H. Clarke   +2 more
doaj   +1 more source

Nerve Bundle Density and Expression of NGF and IL-1β Are Intra-Individually Heterogenous in Subtypes of Endometriosis

Biomolecules
Endometriosis is a gynecological disorder associated with local inflammation and neuroproliferation. Increased nerve bundle density has been attributed to increased expression of nerve growth factor (NGF) and interleukin–1β (IL-1β).
Mahfuza Sreya, Dwayne R. Tucker, Jennifer Yi, Fahad T. Alotaibi, Anna F. Lee, Heather Noga, Paul J. Yong   +6 more
doaj   +1 more source

Effect of Lactobacillus reuteri probiotic on gingival index and Interleukin-1β levels of children with thalassemia experiencing gingivitis

Journal of Indian Society of Pedodontics and Preventive Dentistry
Context: Thalassemia is a genetic blood disorder caused by gene mutation leading to chronic anemia, and patients will need routine blood transfusions as a lifetime supportive therapy.
Indira Betari Sumendap, Heriandi Sutadi, Eva Fauziah, Pustika Amalia Wahidiyat   +3 more
doaj   +1 more source

Interleukin-1β-Induced Promatrilysin Expression is Mediated by NFκB-Regulated Synthesis of Interleukin-6 in the Prostate Carcinoma Cell Line, LNCaP

Neoplasia: An International Journal for Oncology Research, 2001
Previously, our laboratory showed that interleukin-1β (IL-1β) secreted by lipopolysaccharide-activated monocytes induces promatrilysin expression in the prostate carcinoma cell line, LNCaP.
Mimi Suzanne Maliner-Stratton, Russell D. Klein, Thirupandiyur S. Udayakumar, Raymond B. Nagle, George Timothy Bowden   +4 more
doaj   +1 more source

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme.

Immunity, 2015
Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses.
Inna S. Afonina, C. Müller, Seamus J. Martin, R. Beyaert   +3 more
semanticscholar   +1 more source

Gasdermin D pore structure reveals preferential release of mature interleukin-1

Nature, 2021
S. Xia, Zhibin Zhang, V. Magupalli, J. Pablo, Ying Dong, Setu M. Vora, Longfei Wang, T. Fu, Matthew P. Jacobson, A. Greka, J. Lieberman, J. Ruan, Hao Wu   +12 more
semanticscholar   +1 more source

Effect of interleukin-1β on cell proliferation [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2003
Interleukin-1 (IL-1), a pro-inflammatory cytokine, has been undergoing clinical evaluation for its anti-neoplastic activity in potentiating the immune response.
Athip Nilkaeo
doaj