Results 1 to 10 of about 703,665 (265)

Efficacy of Anakinra on Multiple Coronary Arteries Aneurysms in an Infant with Recurrent Kawasaki Disease, Complicated by Macrophage Activation Syndrome

Children, 2022
Kawasaki disease (KD) is rare in infants less than 3 months of age, and its recurrence is exceptional. Infants with KD are at higher risk of severe clinical presentation, therapy failure, complications and coronary aneurysms (CAAs), and this is the ...
Grazia Bossi, Alessia Claudia Codazzi, Federica Vinci, Edoardo Clerici, Corrado Regalbuto, Carmela Crapanzano, Daniele Veraldi, Alice Moiraghi, Gian Luigi Marseglia   +8 more
doaj   +1 more source

Affinity Capture Elution (ACE) ELISA Method Development and Validation for Novel RPH-104 Drug Immunogenicity Evaluation

Biomedicines, 2022
As the number of therapeutic protein products is growing rapidly, there is a strong need for the development of bioanalytical methods that are easy to perform, specific, sensitive, robust, and affordable.
Maria A. Kolganova, Elizaveta V. Melnik, Elizaveta N. Fisher, Valery V. Smirnov, Alexander M. Vlasov, Vladimir I. Gegechkori, Nikolay A. Shulga, Igor E. Shokhin, Galina V. Ramenskaya   +8 more
doaj   +1 more source

Interleukin-1 Genotype in Periodontitis [PDF]

Archivum Immunologiae et Therapiae Experimentalis, 2019
This paper presents the current knowledge concerning the role of polymorphisms of IL1A and IL1B genes in periodontitis. Attention has been paid to the role of IL-1 in the pathogenesis of the disease, and to the significance of a genetic test, investigating the presence of composite two polymorphisms of IL-1 gene, as a risk factor for severe ...
Aniela Brodzikowska, Renata Górska, Jan Kowalski   +2 more
openaire   +2 more sources

Role of interleukins in heart failure with reduced ejection fraction

Anatolian Journal of Cardiology, 2019
Heart failure (HF) is the leading cause of morbidity and mortality in developed countries, and it is the primary cause of mortality in the elderly worldwide.
Oliwia Anna Segiet, Adam Piecuch, Lukasz Mielanczyk, Marek Michalski, Ewa Nowalany-kozielska   +4 more
doaj   +1 more source

A clinical case of adult-onset Still's disease resistant to therapy with tumor necrosis factor-alpha inhibitors and interleukin-6 inhibitors

Современная ревматология, 2019
The basis of the clinical picture of adult-onset Still's disease is a triad of symptoms, includingfever, arthralgia/arthritis, and characteristic rash called «Still rash».
R. R. Samigullina, E. A. Vasilenko, V. I. Mazurov   +2 more
doaj   +1 more source

Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis

Journal of Innate Immunity, 2020
Double-stranded RNA dependent kinase R (PKR) is originally identified as an intracellular sensor of viral infection, but its role in bacterial infection remains largely unknown. Here we report that PKR was an important regulator of antibacterial immunity
Yanliang Yang, Lingli Xie, Yanjun Zhong, Xiaoli Zhong, Ran Meng, Qianqian Xue, Fang Liang, Kai Zhao, Yiting Tang   +8 more
doaj   +1 more source

Short-term comparison of intraarticular administration of IL-1 receptor antagonist and platelet-rich plasma for osteoarthritis treatment

Medicine Science, 2023
Osteoarthritis (OA) is a prevalent joint condition that affects areas such as the knee, hip, hand, and spine. In treating mild to moderate cases of OA, treatment options such as intraarticular corticosteroids, viscosupplementation, glucosamine and ...
Yasin Guler, Ersin Kuyucu, Adnan Kara, Omer Serdar Hakyemez, Ferhat Say, Ahmet Murat Bulbul   +5 more
doaj   +1 more source

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

eLife, 2017
The ubiquitin ligase TRAF6 is a key regulator of canonical IκB kinase (IKK)/NF-κB signaling in response to interleukin-1 (IL-1) stimulation. Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interactor of TRAF6 in human cells.
Gisela Schimmack, Kenji Schorpp, Kerstin Kutzner, Torben Gehring, Jara Kerstin Brenke, Kamyar Hadian, Daniel Krappmann   +6 more
doaj   +1 more source

Interleukin 1 , interleukin 1  and interleukin 1 receptor gene polymorphisms in psoriatic arthritis [PDF]

Rheumatology, 2004
Objectives. To investigate polymorphisms of interleukin (IL) 1, IL-1 and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement. Methods. One hundred and forty well-characterized patients with PsA were studied.
openaire   +1 more source

Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation

Epigenetics, 2021
Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression. Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through direct
Matt J Barter, Kathleen Cheung, Julia Falk, Andreas C Panagiotopoulos, Caitlin Cosimini, Siobhan O’Brien, Karina Teja-Putri, Graham Neill, David J Deehan, David A. Young   +9 more
doaj   +1 more source