Results 11 to 20 of about 28,282,310 (344)
Interleukin-1 and interleukin-1 antagonism. [PDF]
Blood, 1991 The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a variety of genes and the synthesis of several proteins that, in turn, induce acute and chronic inflammatory changes.
C. Dinarello
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Modulation of adult hippocampal neurogenesis by interleukin 1 signaling [PDF]
Neurobiology of Sleep and Circadian RhythmsAdult hippocampal neurogenesis (AHN) plays a critical role in cognition and emotional regulation. Recent studies have linked compromised AHN to numerous neurological and psychological disorders.
Maria I. Smirnova, Ning Quan
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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Nature Reviews Drug Discovery, 2012 Charles A Dinarello +2 more
exaly +2 more sources
Open Biology, 2022 The cytokine interleukin 1 (IL-1) is an evolutionary innovation of vertebrates. Fish and amphibian have one IL1 gene, while mammals have two copies of IL1, IL1A and IL1B, with distinct expression patterns and differences in their proteolytic activation ...
Eva Hasel de Carvalho +4 more
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Applied Sciences, 2022 Recent studies report that individuals with polymorphisms in the genes that encode for interleukin (IL)-1α and IL-1β (IL-1A and IL1B, respectively) and for IL-1 receptor antagonist (IL-1RN) may be more susceptible in developing peri-implantitis ...
José Maria Cardoso +5 more
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Emerging Therapies for Recurrent Pericarditis: Interleukin‐1 inhibitors
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Recurrent pericarditis (RP) is a complex inflammatory disorder associated with adverse outcomes and poor quality of life. After the first episode of acute pericarditis, a non‐negligible group of patients will fail to achieve complete remission despite ...
Saberio Lo Presti +5 more
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Interleukin-1 in tumor progression, therapy, and prevention.
Cancer Cell, 2021 Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important role in tumor progression. Based on preclinical models and human genetic associations, we surmise that targeting IL-1 should be considered in treating selected human tumors
C. Garlanda, A. Mantovani
semanticscholar +1 more source
Disease Activity Is More Associated with IL-1 Than with IL-6 in Patients with Rheumatoid Arthritis
Life, 2022 Interleukin-1 receptor antagonist (IL-1ra) concentration reflects and is proportional to IL-1 production. Both IL-1 and IL-6 are involved in the pathogenesis of rheumatoid arthritis (RA).
Cristina Almeida-Santiago +6 more
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Interleukin-1 as Innate Mediator of T Cell Immunity
Frontiers in Immunology, 2021 The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC molecules, which allows for a specific T cell response;
Bram Van Den Eeckhout +2 more
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Beyond an inflammatory mediator: Interleukin‐1 in neurophysiology
Experimental Physiology, 2023 Since its discovery in the early 1940s, the interleukin‐1 (IL‐1) cytokine family has been associated primarily with acute and chronic inflammation. The family member IL‐1β is produced by different leucocytes, endothelial cells and epithelial cells.
Tatiane S. Lima
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