Results 1 to 10 of about 149,441 (296)

Solution structure of human interleukin-1 receptor antagonist protein [PDF]

FEBS Letters, 1994
Interleukin‐1 receptor antagonist protein (IRAP) is a naturally occurring inhibitor of the interleukin‐1 receptor. In contrast to IL‐1β IRAP binds to the IL‐1 receptor but does not elicit a physiological response. We have determined the solution structure of IRAP using NMR spectroscopy.
Brian J Stockman, Terrence A scahill, A W Yem   +2 more
exaly   +3 more sources

Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

Mediators of Inflammation, 2007
This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to
Esko Kumpusalo, Hannu Kautiainen, Mauno Vanhala, Juha Saltevo, Markku Laakso   +4 more
doaj   +3 more sources

Recombinant IL-38 Alleviates Temporomandibular Joint Synovial Inflammation via IL-1R1-NF-κB-IL1β Pathway [PDF]

International Dental Journal
Introduction and aims: Interleukin (IL)-38 has been identified as an anti-inflammatory cytokine; however, its specific role in temporomandibular joint (TMJ) synovial inflammation and the identity of its functional receptors remain elusive.
Ping Luo, Xueliang Lv, Jifang Hui, Hu Qiao   +3 more
doaj   +2 more sources

An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1? [PDF]

Diabetologia, 1991
The cytokine interleukin-1 beta may have an important role in the autoimmune mediated damage of pancreatic Beta cells in insulin-dependent diabetes mellitus. In the present study we have investigated the effects of an interleukin-1 receptor antagonist protein, a blocker of the type I interleukin-1 receptor, on the suppressive actions of recombinant ...
Decio L Eizirik, S Sandler, Daniel E Tracey   +2 more
exaly   +4 more sources

Structural and dynamic properties of IL1 receptors [PDF]

Frontiers in Immunology
The study of the structural and dynamic properties of multidomain proteins is of great interest as they constitute one of the main regulatory mechanisms in the ligand–receptor system.
J. V. Zhukova, J. A. Lopatnikova, S. V. Sennikov   +2 more
doaj   +2 more sources

Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation [PDF]

Immunology, 2004
SummaryThe aim of this study was to construct and purify a novel interleukin‐1 receptor antagonist (IL‐1ra)–interleukin‐10 (IL‐10) fusion protein and determine its biological function and anti‐inflammatory effects. The isolated cDNAs of two inhibitory cytokines (IL‐1ra, IL‐10) were used to construct a cDNA for the IL‐1ra–IL‐10 fusion protein.
Deh-Ming Chang, Song-Kun Shyue, Ann Chen   +2 more
exaly   +3 more sources

Content of C-reactive protein, interleukin-1, interleukin-6 and interleukin-1 receptor antagonist in the blood of patients with early osteoarthrosis of the knee joints

Терапевтический архив, 2009
Aim. To analyse the levels of C-reactive protein (CRP), IL-1, IL-6 and IL-1 receptor antagonist (IRA) in the blood of patients with early gonarthrosis (GA). Material and methods. Clinical, x-ray and arthrosonographic examinations to stage GA, to identify
M S Svetlova, N N Vezikova, V V Romashina, T S Sobanina, Yu L Pavlov, I A Cheplyukova, M S Svetlova, N N Vezikova, V V Romashina, T S Sobanina, Yu L Pavlov, I A Cheplyukova   +11 more
doaj   +4 more sources

Interleukin-1 receptor antagonist protein (IL-1Ra) and miR-140 overexpression via pNNS-conjugated chitosan-mediated gene transfer enhances the repair of full-thickness cartilage defects in a rabbit model [PDF]

Bone and Joint Research, 2019
Zhao R, Wang S, Jia L, Li Q, Qiao J, Peng X.   +5 more
exaly   +2 more sources

Interleukin-1 in Febrile Infection-Related Epilepsy Syndrome [PDF]

Annals of Child Neurology, 2023
Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection and accompanied by fulminant ...
Joon Won Kang, Sookyong Koh
doaj   +1 more source

Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

ERJ Open Research, 2023
Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been ...
Andreas Rydell, Elisabet Nerpin, XingWu Zhou, Lars Lind, Eva Lindberg, Jenny Theorell Haglöw, Tove Fall, Christer Janson, Karin Lisspers, Sölve Elmståhl, Suneela Zaigham, Olle Melander, Peter M. Nilsson, Johan Ärnlöv, Andrei Malinovschi   +14 more
doaj   +1 more source