Results 11 to 20 of about 81,393 (255)

Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist [PDF]

Applied Radiation and Isotopes, 2010
IL-1RA is a naturally occurring antagonist of the pro-inflammatory cytokine interleukin-1 (IL-1) with high therapeutic promise, but its pharmacokinetic remains poorly documented. In this report, we describe the radiolabeling of recombinant human interleukin-1 receptor antagonist (rhIL-1RA) with fluorine-18 to allow pharmacokinetic studies by positron ...
Prenant, C., Cawthorne, C., Fairclough, M., Rothwell, N., Boutin, H.; id_orcid 0000-0002-0029-5246   +4 more
openaire   +3 more sources

Clinical and Functional Results Using Autologous Conditioned Serum in the Treatment of Acute Ankle Injuries in Sporting Activities

Journal of Orthopedic and Spine Trauma, 2022
Background: Ankle ligament injuries in the sports like basketball, volleyball, and cricket are the most common reasons for missed participation in athletics, accounting for 14% of all sports injuries.
Satya Kumar Koduru, Balakrishhna Bathina, Manidhar Sane   +2 more
doaj   +1 more source

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort

Critical Care Explorations, 2021
OBJECTIVES:. Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronavirus
Nishkantha Arulkumaran, PhD, Timothy Arthur Chandos Snow, FFICM, Adarsh Kulkarni, MD, David Brealey, PhD, Hannah Rickman, MB BChir, Chloe Rees-Spear, MSc, Moira J. Spyer, PhD, Judith Heaney, PhD, Edmund Garr, PhD, Bryan Williams, PhD, Peter Cherepanov, PhD, George Kassiotis, PhD, Michael Lunn, PhD, Catherine Houlihan, PhD, Laura E. McCoy, PhD, Eleni Nastouli, FRCPath, Mervyn Singer, FRCP   +16 more
doaj   +1 more source

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia [PDF]

Brazilian Journal of Medical and Biological Research, 2016
We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia.
W. Eik Filho, S.S. Marcon, T. Krupek, I.T.S. Previdelli, O.C.N. Pereira, M.A.R.C.P. Silva, R.B. Bazotte   +6 more
doaj   +3 more sources

Anakinra to Mitigate Hemophagocytic Lymphohistiocytosis-Like Toxicity Following Chimeric Antigen Receptor T-cell Therapy in Pediatric B-cell ALL

Clinical Pediatric Hematology-Oncology, 2022
Hemophagocytic lymphohistiocytosis-like toxicity following chimeric antigen receptor (CAR)-T cell therapy (carHLH) is a rare and fulminant complication.
Na Yoon Lee, Suejung Jo, Jae Won Yoo, Seongkoo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho   +6 more
doaj   +1 more source

Change in Eosinophil Count in Patients with Heart Failure Treated with Anakinra

Cells, 2023
Background: Interleukin-1 blockade with anakinra leads to a transient increase in eosinophil blood count (eosinophils) in patients with acute myocardial infarction. We aimed to investigate the effect of anakinra on changes in eosinophils in patients with
Michele Golino, Francesco Moroni, Marco Giuseppe Del Buono, Justin M. Canada, Azita H. Talasaz, Sebastian Piñel, James Mbualungu, Alessandra Vecchiè, Ai-Chen (Jane) Ho, Georgia K. Thomas, Salvatore Carbone, Hayley E. Billingsley, Jeremy Turlington, Roshanak Markley, Cory Trankle, Roberto De Ponti, Benjamin Van Tassell, Antonio Abbate   +17 more
doaj   +1 more source

Biologic effects of an interleukin‐1 receptor antagonist protein on interleukin‐1–stimulated cartilage erosion and chondrocyte responsiveness [PDF]

Arthritis & Rheumatism, 1991
AbstractRecombinant human interleukin‐1α (IL‐1α) and recombinant human IL‐1β stimulate matrix proteoglycan degradation and inhibit glycosaminoglycan synthesis in bovine nasal cartilage explants. A 17‐kd human recombinant IL‐1 receptor antagonist protein (IRAP) caused a concentration‐dependent (0.2–200 ng/ml) suppression of the effects of IL‐1α and IL ...
R J, Smith, J E, Chin, L M, Sam, J M, Justen   +3 more
openaire   +2 more sources

A new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum

Orthopedic Reviews, 2013
The purpose of the present study was to investigate the effect of intra-articular injections of autologous conditioned serum on human hip osteoarthritis and to test whether a potential treatment effect might be increased by additional injections of ...
Axel W.A. Baltzer, Martin S. Ostapczuk, Daniel Stosch, Florian Seidel, Markus Granrath   +4 more
doaj   +1 more source

Cloning and Expression of Recombinant Human Interleukin 1 Receptor Antagonist in Escherichia Coli Strains, BL21 (DE3), Rosetta (DE3), and Origami (DE3)

مجله دانشکده پزشکی اصفهان, 2019
Background: Recombinant human interleukin-1 receptor antagonist (IL-1RA) is a protein with 153 amino acids and molecular weight of 16.83 kDa. This drug protein is known as Anakinra, and has an effective application in the treatment of rheumatoid ...
Hanieh Fardgoli, Seyed Nezameddin Hoseini, Setareh Haghighat   +2 more
doaj   +1 more source