Results 11 to 20 of about 32,812,329 (299)

The interleukin-1 receptor antagonist influences interleukin-1 effects in rat and mouse [PDF]

open access: yesMediators of Inflammation, 1992
In this work we have focused on the ability of interleukin-1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo.
P. Bjrök, K. Ohlsson
doaj   +2 more sources

Clinical and Functional Results Using Autologous Conditioned Serum in the Treatment of Acute Ankle Injuries in Sporting Activities

open access: yesJournal of Orthopedic and Spine Trauma, 2022
Background: Ankle ligament injuries in the sports like basketball, volleyball, and cricket are the most common reasons for missed participation in athletics, accounting for 14% of all sports injuries.
Satya Kumar Koduru   +2 more
doaj   +1 more source

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

open access: yesPharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng   +7 more
doaj   +1 more source

Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort

open access: yesCritical Care Explorations, 2021
OBJECTIVES:. Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronavirus
Nishkantha Arulkumaran, PhD   +16 more
doaj   +1 more source

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia [PDF]

open access: yesBrazilian Journal of Medical and Biological Research, 2016
We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia.
W. Eik Filho   +6 more
doaj   +3 more sources

Anakinra to Mitigate Hemophagocytic Lymphohistiocytosis-Like Toxicity Following Chimeric Antigen Receptor T-cell Therapy in Pediatric B-cell ALL

open access: yesClinical Pediatric Hematology-Oncology, 2022
Hemophagocytic lymphohistiocytosis-like toxicity following chimeric antigen receptor (CAR)-T cell therapy (carHLH) is a rare and fulminant complication.
Na Yoon Lee   +6 more
doaj   +1 more source

Change in Eosinophil Count in Patients with Heart Failure Treated with Anakinra

open access: yesCells, 2023
Background: Interleukin-1 blockade with anakinra leads to a transient increase in eosinophil blood count (eosinophils) in patients with acute myocardial infarction. We aimed to investigate the effect of anakinra on changes in eosinophils in patients with
Michele Golino   +17 more
doaj   +1 more source

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist : a Mendelian randomisation analysis [PDF]

open access: yes, 2015
Funded by: UK Medical Research Council, British Heart Foundation, UK National Institute for Health Research, National Institute for Health Research Cambridge Biomedical Research Centre, European Research Council, and European Commission Framework ...
D. F. Easton (7608179)   +874 more
core   +5 more sources

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes:the MRC-ILA Heart Study [PDF]

open access: yes, 2014
AIMS: Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation.
Greenwood, J.P.   +29 more
core   +1 more source

A new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum

open access: yesOrthopedic Reviews, 2013
The purpose of the present study was to investigate the effect of intra-articular injections of autologous conditioned serum on human hip osteoarthritis and to test whether a potential treatment effect might be increased by additional injections of ...
Axel W.A. Baltzer   +4 more
doaj   +1 more source

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