Autoinflammatory diseases can cause severe inflammation in bone and skin such as neonatal-onset multisystem inflammatory disease (NOMID), Majeed syndrome, interleukin-36 receptor antagonist deficiency (DITRA) and deficiency of interleukin-1 (IL-1 ...
Betül Sözeri +4 more
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The interleukin-1 receptor antagonist influences interleukin-1 effects in rat and mouse
In this work we have focused on the ability of interleukin-1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo.
P. Bjrök, K. Ohlsson
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Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. [PDF]
Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions. To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated from liver biopsies and HepG2 hepatoma cells were stimulated
C, Gabay +3 more
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Recurrent pericarditis is a common complication of acute pericarditis (15–30%) for which, in most cases, no underlying etiology is found [idiopathic recurrent pericarditis (IRP)]. IRP is currently viewed as an autoinflammatory disease with characteristic
George Lazaros +2 more
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Background and Aims Major depressive disorder (MDD) is characterized by the occurrence of one or more depressive episodes lasting a minimum of 2 weeks and is marked by a persistently low mood and a lack of enjoyment in daily activities.
Zabun Nahar +3 more
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Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β
AbstractTransforming growth factor‐β1 (TGF‐β1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF‐β1 can stimulate the production of IL6 and platelet‐derived growth factor, indicating that TGF‐β1 initiates complex effects on the production of cytokines ...
Turner, M +5 more
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Soluble interleukin‐1 receptor accessory protein ameliorates collagen‐induced arthritis by a different mode of action from that of interleukin‐1 receptor antagonist [PDF]
AbstractObjectiveTo discern the mode of interleukin‐1 (IL‐1) inhibition of soluble IL‐1 receptor accessory protein (sIL‐1RAcP) by comparison with IL‐1 receptor antagonist (IL‐1Ra) in arthritis.MethodsAdenoviral vectors encoding either sIL‐1RAcP or IL‐1Ra were administered systemically before onset of collagen‐induced arthritis in DBA/1 mice.
Smeets, R.L.L. +8 more
openaire +3 more sources
Host genome polymorphisms and tuberculosis infection: What we have to say?
Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection.
Said Alfin Khalilullah +5 more
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Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction. [PDF]
Helicobacter pylori infection and interleukin-1 polymorphisms are associated with an increased risk of gastric cancer. We examined the prevalence of Helicobacter pylori seropositivity and interleukin-1 polymorphisms between ST-segment elevation ...
Noriaki Tabata +15 more
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The experimental treatment of corneal graft rejection with the interleukin-1 receptor antagonist (IL-1ra) gene. [PDF]
PURPOSE: To investigate the protective effects of interleukin-1 receptor antagonist (IL-1ra) gene transfer in a rat model of corneal graft rejection.
Jin Yuan +5 more
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