Results 21 to 30 of about 81,393 (255)

A novel mutation of interleukin-1 receptor antagonist (IL1RN) in a DIRA patient from Turkey: Diagnosis and treatment

open access: yesThe Turkish Journal of Pediatrics, 2018
Autoinflammatory diseases can cause severe inflammation in bone and skin such as neonatal-onset multisystem inflammatory disease (NOMID), Majeed syndrome, interleukin-36 receptor antagonist deficiency (DITRA) and deficiency of interleukin-1 (IL-1 ...
Betül Sözeri   +4 more
doaj   +1 more source

The interleukin-1 receptor antagonist influences interleukin-1 effects in rat and mouse

open access: yesMediators of Inflammation, 1992
In this work we have focused on the ability of interleukin-1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo.
P. Bjrök, K. Ohlsson
doaj   +1 more source

Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. [PDF]

open access: yesJournal of Clinical Investigation, 1997
Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions. To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated from liver biopsies and HepG2 hepatoma cells were stimulated
C, Gabay   +3 more
openaire   +2 more sources

The Therapeutic Role of Interleukin-1 Inhibition in Idiopathic Recurrent Pericarditis: Current Evidence and Future Challenges

open access: yesFrontiers in Medicine, 2017
Recurrent pericarditis is a common complication of acute pericarditis (15–30%) for which, in most cases, no underlying etiology is found [idiopathic recurrent pericarditis (IRP)]. IRP is currently viewed as an autoinflammatory disease with characteristic
George Lazaros   +2 more
doaj   +1 more source

Evaluation of serum interleukin‐1 receptor antagonist levels in major depressive disorder: A case‐control study

open access: yesHealth Science Reports, 2023
Background and Aims Major depressive disorder (MDD) is characterized by the occurrence of one or more depressive episodes lasting a minimum of 2 weeks and is marked by a persistently low mood and a lack of enjoyment in daily activities.
Zabun Nahar   +3 more
doaj   +1 more source

Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β

open access: yesEuropean Journal of Immunology, 1991
AbstractTransforming growth factor‐β1 (TGF‐β1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF‐β1 can stimulate the production of IL6 and platelet‐derived growth factor, indicating that TGF‐β1 initiates complex effects on the production of cytokines ...
Turner, M   +5 more
openaire   +2 more sources

Soluble interleukin‐1 receptor accessory protein ameliorates collagen‐induced arthritis by a different mode of action from that of interleukin‐1 receptor antagonist [PDF]

open access: yesArthritis & Rheumatism, 2005
AbstractObjectiveTo discern the mode of interleukin‐1 (IL‐1) inhibition of soluble IL‐1 receptor accessory protein (sIL‐1RAcP) by comparison with IL‐1 receptor antagonist (IL‐1Ra) in arthritis.MethodsAdenoviral vectors encoding either sIL‐1RAcP or IL‐1Ra were administered systemically before onset of collagen‐induced arthritis in DBA/1 mice.
Smeets, R.L.L.   +8 more
openaire   +3 more sources

Host genome polymorphisms and tuberculosis infection: What we have to say?

open access: yesEgyptian Journal of Chest Disease and Tuberculosis, 2014
Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection.
Said Alfin Khalilullah   +5 more
doaj   +1 more source

Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction. [PDF]

open access: yesPLoS ONE, 2016
Helicobacter pylori infection and interleukin-1 polymorphisms are associated with an increased risk of gastric cancer. We examined the prevalence of Helicobacter pylori seropositivity and interleukin-1 polymorphisms between ST-segment elevation ...
Noriaki Tabata   +15 more
doaj   +1 more source

The experimental treatment of corneal graft rejection with the interleukin-1 receptor antagonist (IL-1ra) gene. [PDF]

open access: yesPLoS ONE, 2013
PURPOSE: To investigate the protective effects of interleukin-1 receptor antagonist (IL-1ra) gene transfer in a rat model of corneal graft rejection.
Jin Yuan   +5 more
doaj   +1 more source

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