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Interleukin-6 Family Cytokines [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine (CLC), and IL-27. They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and ...
S. Rose-John
openaire   +3 more sources

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

medRxiv, 2021
Background: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. Methods: We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform ...
A. Gordon, P. Mouncey, Farah Al-Beidh, K. Rowan, A. Nichol, Y. Arabi, D. Annane, A. Beane, Wilma van Bentum-Puijk, L. Berry, Zahra Bhimani, M. Bonten, C. Bradbury, F. Brunkhorst, Adrian Buzgau, A. Cheng, M. Detry, E. J. Duffy, L. Estcourt, M. Fitzgerald, H. Goossens, R. Haniffa, A. Higgins, T. Hills, Christopher M. Horvat, F. Lamontagne, P. Lawler, H. Leavis, K. Linstrum, E. Litton, E. Lorenzi, J. Marshall, F. Mayr, D. McAuley, A. McGlothlin, S. McGuinness, B. McVerry, S. Montgomery, S. Morpeth, S. Murthy, Katrina Orr, R. Parke, Jane C. Parker, A. Patanwala, V. Pettilä, E. Rademaker, Marlene S. Santos, Christina T. Saunders, C. Seymour, M. Shankar-Hari, W. Sligl, A. Turgeon, Anne M Turner, F. L. van de Veerdonk, R. Zarychanski, Cameron Green, R. Lewis, D. Angus, C. McArthur, S. Berry, S. Webb, L. Derde   +61 more
semanticscholar   +1 more source

Interleukin 6: at the interface of human health and disease

Frontiers in Immunology, 2023
Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier permeability, synovial inflammation, hematopoiesis, and embryonic ...
Elena Grebenciucova, Stephen VanHaerents
semanticscholar   +1 more source

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach.

International Immunopharmacology, 2022
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both pro-inflammatory and anti-inflammatory activity, depending on the immune response context.
Mansur Aliyu, F. Zohora, A. Anka, Kashif Ali, S. Maleknia, Mohammad Saffarioun, G. Azizi   +6 more
semanticscholar   +1 more source

Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease

Circulation Research, 2021
IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of physiological functions traditionally associated with host defense, immune cell regulation, proliferation, and differentiation.
P. Ridker, Manas Rane
semanticscholar   +1 more source

Interleukin-6 Promoter Haplotypes and Interleukin-6 Cytokine Responses [PDF]

Shock, 2003
Genetic variations contribute to differences in the inflammatory response and are markers for disease risk and outcomes. We studied three single-nucleotide polymorphisms (-597 G-->A, -572 G-->C, and -174 G-->C) in the IL-6 promoter to determine associations with ex vivo LPS-stimulated IL-6 production by leukocytes.
Fernando A, Rivera-Chavez, Dixie L, Peters-Hybki, Robert C, Barber, Grant E, O'Keefe   +3 more
openaire   +2 more sources

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity.

Cancer Cell, 2022
Immune checkpoint blockade (ICB) therapy frequently induces immune-related adverse events. To elucidate the underlying immunobiology, we performed a deep immune analysis of intestinal, colitis, and tumor tissue from ICB-treated patients with parallel ...
Y. Hailemichael, Daniel H. Johnson, N. Abdel-Wahab, W. Foo, S. Bentebibel, May Daher, C. Haymaker, K. Wani, C. Saberian, D. Ogata, Sang T Kim, R. Nurieva, A. Lazar, Hamzah Abu-Sbeih, Faisal Fa’ak, A. Mathew, Yinghong Wang, Adewunmi Falohun, V. Trinh, Chrystia M Zobniw, Christine Spillson, J. Burks, M. Awiwi, K. Elsayes, L. S. Soto, Brenda D. Melendez, M. Davies, J. Wargo, Jon K. Curry, C. Yee, G. Lizée, Shalini Singh, Padmanee Sharma, J. Allison, P. Hwu, S. Ekmekcioglu, A. Diab   +36 more
semanticscholar   +1 more source

Interleukin-6, age, and corpus callosum integrity. [PDF]

, 2014
The contribution of inflammation to deleterious aging outcomes is increasingly recognized; however, little is known about the complex relationship between interleukin-6 (IL-6) and brain structure, or how this association might change with increasing age.
Bettcher, Brianne M, Busovaca, Edgar, Dutt, Shubir, Green, Ralph, Kramer, Joel H, Lobach, Iryna V, Miller, Bruce L, Miller, Joshua W, Neuhaus, John, Patel, Nihar, Rosen, Howard J, Walsh, Christine M, Watson, Christa L, Yaffe, Kristine   +13 more
core   +6 more sources

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

International Journal of Antimicrobial Agents, 2020
Highlights • Pathogenesis of cytokine release syndrome (CRS) in severe COVID-19 patients.• Key role of interleukin-6 (IL-6) in CRS.• IL-6 receptor (IL-6R) antagonist tocilizumab suggested as a possible drug for severe COVID-19.
Chi Zhang, Zhao Wu, Jiawen Li, Hong Zhao, Guiqiang Wang   +4 more
semanticscholar   +1 more source

Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

Experimental and Molecular Medicine, 2021
Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue injuries and is a bioindicator of multiple distinct types of cytokine storms.
Sujin Kang, T. Kishimoto
semanticscholar   +1 more source