Results 1 to 10 of about 308,594 (267)

Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock. [PDF]

PLoS ONE, 2017
BACKGROUND:The objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163),
Juan-Jesús Ríos-Toro, Mercedes Márquez-Coello, José-María García-Álvarez, Andrés Martín-Aspas, Ricardo Rivera-Fernández, Ana Sáez de Benito, José-Antonio Girón-González   +6 more
doaj   +2 more sources

Consensus statement on blocking interleukin-6 receptor and interleukin-6 in inflammatory conditions: an update [PDF]

Annals of the Rheumatic Diseases, 2023
Targeting interleukin (IL)-6 has become a major therapeutic strategy in the treatment of immune-mediated inflammatory disease. Interference with the IL-6 pathway can be directed at the specific receptor using anti-IL-6Rα antibodies or by directly inhibiting the IL-6 cytokine.
Daniel Aletaha, Andreas Kerschbaumer, Kastriot Kastrati, Christian Dejaco, Maxime Dougados, Iain B McInnes, Naveed Sattar, Tanja A Stamm, Tsutomu Takeuchi, Michael Trauner, Désirée van der Heijde, Marieke Voshaar, Kevin L Winthrop, Angelo Ravelli, Neil Betteridge, Gerd-Rüdiger R Burmester, Johannes WJ Bijlsma, Vivian Bykerk, Roberto Caporali, Ernest H Choy, Catalin Codreanu, Bernard Combe, Mary K Crow, Maarten de Wit, Paul Emery, Roy M Fleischmann, Cem Gabay, Merete Lund Hetland, Kimme L Hyrich, Annamaria Iagnocco, John D Isaacs, Joel M Kremer, Xavier Mariette, Peter A Merkel, Eduardo F Mysler, Peter Nash, Michael T Nurmohamed, Karel Pavelka, Gyula Poor, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Anja Strangfeld, Yoshiya Tanaka, Josef S Smolen   +43 more
openaire   +13 more sources

Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study

Frontiers in Medicine, 2021
Purpose: Emerging evidence suggests a potential role of interleukin-6 pathways—trans-signaling with soluble interleukin-6 receptors—in the asthma pathobiology.
Yoshihiko Raita, Zhaozhong Zhu, Carlos A. Camargo, Robert J. Freishtat, Robert J. Freishtat, Robert J. Freishtat, Debby Ngo, Liming Liang, Liming Liang, Kohei Hasegawa   +9 more
doaj   +1 more source

Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease [PDF]

Blood, 1991
Interleukin-6 (IL-6) is a multipotent lymphokine that can mediate differentiation of B cells into Ig-secreting cells, stimulate the growth of plasmacytomas, hybridomas, and T cells, and induce acute- phase proteins in liver cells. It has been suggested that IL-6 is involved in the pathogenesis of several diseases by autocrine or paracrine pathways.
M, Jücker, H, Abts, W, Li, R, Schindler, H, Merz, A, Günther, C, von Kalle, M, Schaadt, T, Diamantstein, A C, Feller   +9 more
openaire   +3 more sources

In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 Receptor

Frontiers in Immunology, 2022
Various metabolites identified with therapeutic mushrooms have been found from different sources and are known to have antibacterial, antiviral, and anticancer properties.
Faez Iqbal Khan, Fakhrul Hassan, Dakun Lai   +2 more
doaj   +1 more source

Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice

Frontiers in Immunology, 2022
Natural killer (NK) cells are important effectors of the innate immune system and participate in the first line of defense against infections and tumors.
Neha D. Patil, Neha D. Patil, Olivia Domingues, Cécile Masquelier, Maud Theresine, Oceane Schlienger, Clinton Njinju Amin Asaba, Marine Thomas, Carole Seguin-Devaux, Hortense Slevogt, Markus Ollert, Markus Ollert, Jacques Zimmer   +12 more
doaj   +1 more source

On the role of bacterial metalloproteases in COVID-19 associated cytokine storm

Cell Communication and Signaling, 2021
The cytokine release syndrome or cytokine storm, which is the hyper-induction of inflammatory responses has a central role in the mortality rate of COVID-19 and some other viral infections.
László Földvári-Nagy, Tamás Schnabel, Gabriella Dörnyei, Tamás Korcsmáros, Katalin Lenti   +4 more
doaj   +1 more source

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice

Frontiers in Neurology, 2021
Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and regulate synaptic transmission, astrocyte function, and microglial reactivity.
Federica Mastroiacovo, Manuela Zinni, Giada Mascio, Valeria Bruno, Valeria Bruno, Giuseppe Battaglia, Giuseppe Battaglia, Julien Pansiot, Tiziana Imbriglio, Jerome Mairesse, Jerome Mairesse, Olivier Baud, Olivier Baud, Olivier Baud, Ferdinando Nicoletti, Ferdinando Nicoletti   +15 more
doaj   +1 more source

Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors

iScience, 2021
Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner, Doreen Manuela Floss, Jürgen Scheller   +2 more
doaj   +1 more source

Frontiers in Drug Research and Development for Inflammatory Bowel Disease

Frontiers in Pharmacology, 2017
Inflammatory bowel disease (IBD) is idiopathic, lifelong, immune-mediated diseases, for which curative therapies are not yet available. In the last 15 years, the introduction of monoclonal antibodies targeting tumor necrosis factor-α, a cytokine playing ...
Diego Currò, Daniela Pugliese, Alessandro Armuzzi   +2 more
doaj   +1 more source