Results 21 to 30 of about 308,594 (267)

Regulation of interleukin‐6 receptor expression by interleukin‐6 in human monocytes — a re‐examination [PDF]

FEBS Letters, 1994
We have studied the expression and regulation of the interleukin‐6 receptor (gp80) and its signal transducer gp13O in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27–30] we find that neither lipopolysaccharide nor interleukin‐
Schoester, Monika, Heinrich, Peter, Graeve, Lutz   +2 more
openaire   +3 more sources

Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes

Journal of Pharmacological Sciences, 2006
UTP causes interleukin (IL)-6 production via mRNA expression through P2Y2/P2Y4 receptors in human HaCaT keratinocytes. In the present study, we analyzed the mechanism of UTP-induced IL-6 production in these cells.
Daisaku Kobayashi, Satoko Ohkubo, Norimichi Nakahata   +2 more
doaj   +1 more source

Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. [PDF]

PLoS ONE, 2015
Extracellular nucleotides, such as ATP, are released from cells in response to various stimuli and act as intercellular signaling molecules through activation of P2 receptors.
Ayumi Kawano, Remi Kadomatsu, Miyu Ono, Shuji Kojima, Mitsutoshi Tsukimoto, Hikaru Sakamoto   +5 more
doaj   +1 more source

Morphine Attenuates Apically-Directed Cytokine Secretion from Intestinal Epithelial Cells in Response to Enteric Pathogens

Pathogens, 2014
Epithelial cells represent the first line of host immune defense at mucosal surfaces. Although opioids appear to increase host susceptibility to infection, no studies have examined opioid effects on epithelial immune functions.
Amanda J. Brosnahan, Bryan J. Jones, Cheryl M. Dvorak, David R. Brown   +3 more
doaj   +1 more source

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. [PDF]

Proceedings of the National Academy of Sciences, 1993
It has been reported that soluble interleukin (IL)-6 receptor (sIL-6R) is detected in the serum of healthy individuals and its level is increased in patients with multiple myeloma and human immunodeficiency virus infection. Although several reports have suggested that sIL-6R potentiates IL-6 action, its physiological role remains unclear. In this study,
T, Tamura, N, Udagawa, N, Takahashi, C, Miyaura, S, Tanaka, Y, Yamada, Y, Koishihara, Y, Ohsugi, K, Kumaki, T, Taga   +9 more
openaire   +2 more sources

Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

Frontiers in Genetics
BackgroundAcute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as Interleukin-8, −2, −6, and −1β ...
Jia-wei Ma, Jia-wei Ma, Ji-chun Tang, Hong-zhi Fang   +3 more
doaj   +1 more source

Cortisol Dose-Dependently Impairs Migration and Tube-like Formation in a Trophoblast Cell Line and Modulates Inflammatory and Angiogenic Genes

Biomedicines, 2021
Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of the embryo and the placental tissue itself.
Talita Guerreiro Rodrigues Húngaro, Marcos F. Gregnani, Thaís Alves-Silva, Florian Herse, Natalia Alenina, Michael Bader, Ronaldo C. Araújo   +6 more
doaj   +1 more source

Effects of ulinastatin on global ischemia via brain pro-inflammation signal

Translational Neuroscience, 2016
Ulinastatin [urinary trypsin inhibitor (UTI)] plays an important role in the protection of organs against ischemic injury during severe inflammation.
Jiang Xiao-Ming, Hu Jing-Hai, Wang Lu-Lu, Ma Chi, Wang Xu, Liu Xiao-Liang   +5 more
doaj   +1 more source

Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action

Research in Pharmaceutical Sciences, 2021
Background and purpose: Kaempferol (KM), a flavonoid, has an anti-inflammatory and anticancer effect and prevents many metabolic diseases. Nonetheless, very few studies have been done on the antinociceptive effects of KM. This research aimed at assessing
Sajjad Jabbari, Maryam Bananej, Mohammad Zarei, Alireza Komaki, Ramin Hajikhani   +4 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source