Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection [PDF]
Frontiers in ImmunologyIntroductionSerum levels of interleukin-6 (IL-6) are increased in COVID-19 patients. IL-6 is an effective therapeutic target in inflammatory diseases and tocilizumab, a monoclonal antibody that blocks signaling via the IL-6 receptor (IL-6R), is used to ...
Juliane Lokau +10 more
doaj +2 more sources
Human retinal endothelial cells express functional interleukin-6 receptor [PDF]
Journal of Ophthalmic Inflammation and Infection, 2023 Background Interleukin (IL)-6 is an inflammatory cytokine present in the eye during non-infectious uveitis, where it contributes to the progression of inflammation.
Lisia Barros Ferreira +6 more
doaj +2 more sources
Evaluation of interleukin‐1 and interleukin‐6 receptor antagonists in a murine model of acute lung injury [PDF]
Experimental PhysiologyThe acute exudative phase of acute respiratory distress syndrome (ARDS), a severe form of respiratory failure, is characterized by alveolar damage, pulmonary oedema, and an exacerbated inflammatory response.
Émilie Meunier +8 more
doaj +2 more sources
Interleukin-6 Receptor Gene rs1800795 Polymorphism and Expression of Interleukin-6 in Gingival Tissue in Patients with Periodontitis [PDF]
MicroorganismsPeriodontitis is a multifactorial inflammatory disease. This chronic periodontal disease is caused by a bacterial infection in the gums, which triggers a host inflammatory response.
Małgorzata Mazurek-Mochol +6 more
doaj +2 more sources
A Mendelian Randomization Study and Experimental Validation Investigating the Potential Relationship Among Interleukin‐6 Receptor Subunit Beta, Obesity, and Alzheimer's Disease [PDF]
Brain and BehaviorObjective This study employs Mendelian randomization (MR) aimed at systematically evaluating the relationship among interleukin‐6 receptor subunit beta, obesity, and Alzheimer's disease (AD). We conducted animal studies to validate the reliability of the
Yu Liu +4 more
doaj +2 more sources
Treatment of severe covid-19 with interleukin 6 receptor inhibition [PDF]
BMJ Medicine, 2022 Stephen Burgess +2 more
doaj +2 more sources
Interleukin-1 Beta rs16944 and rs1143634 and Interleukin-6 Receptor rs12083537 Single Nucleotide Polymorphisms as Potential Predictors of COVID-19 Severity [PDF]
PathogensHost genetic variation has been recognized as a key predictor of diverse clinical sequelae among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients.
Inas A. Ahmed +8 more
doaj +2 more sources
Interleukin-6 receptor polymorphism is prevalent in HIV-negative Castleman Disease and is associated with increased soluble interleukin-6 receptor levels. [PDF]
PLoS ONE, 2013 Multicentric Castleman Disease is largely driven by increased signaling in the pathway for the plasma cell growth factor interleukin-6. We hypothesized that interleukin-6/interleukin-6 receptor/gp130 polymorphisms contribute to increased interleukin-6 ...
Katie Stone +11 more
doaj +1 more source
Frontiers in Physiology, 2021 Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling.
Paulina Villar-Fincheira +15 more
doaj +1 more source
Criteria for the optimal use of interleukin-6 receptor blockers in patients with COVID-19
Терапевтический архив, 2021 Aim. To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes. Materials and methods.
Tatyana S. Kruglova +11 more
doaj +1 more source