Results 11 to 20 of about 467,392 (261)

Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners

Frontiers in Physiology, 2021
Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling.
Paulina Villar-Fincheira, Aaron J. Paredes, Tomás Hernández-Díaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceño, Felipe Contreras-Briceño, Jorge Mandiola, Nicole Bruneau, Lorena García, María Paz Ocaranza, María Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong   +15 more
doaj   +1 more source

Criteria for the optimal use of interleukin-6 receptor blockers in patients with COVID-19

Терапевтический архив, 2021
Aim. To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes. Materials and methods.
Tatyana S. Kruglova, Darya S. Fomina, Nataliya G. Poteshkina, Nadija F. Frolova, Irina P. Beloglazova, Zinaida Yu. Mutovina, Inna V. Samsonova, Elena A. Kovalevskaja, Alena I. Zagrebneva, Sofya A. Serdotetckova, Anton A. Chernov, Maryana A. Lysenko   +11 more
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Management of patients with rheumatoid arthritis in real clinical practice: Switching from interleukin 6 receptor inhibitors to interleukin 6 inhibitor (olokizumab)

Научно-практическая ревматология, 2023
Aim. Switching to another biologic with the same mode of action provides greater opportunity for long-term management of patients with rheumatoid arthritis (RA).
A. A. Baranov, I. B. Vinogradova, O. N. Anoshenkova, O. V. Antipova, E. A. Bogdanova, Y. Y. Grabovetskaya, E. P. Ilivanova, A. N. Kalyagin, I. N. Kushnir, N. A. Lapkina, M. V. Mokrousova, O. B. Nesmeyanova, N. M. Nikitina, P. A. Shesternya, N. V. Yudina, E. Feist, E. L. Nasonov   +16 more
doaj   +1 more source

Cardiometabolic risk factors and their relationship with the interleukin-6 receptor gene polymorphism (rs2228145) in patients with hypertrophic cardiomyopathy

Российский кардиологический журнал, 2020
Aim. To analyze associations of interleukin-6 receptor gene (IL6R) polymorphism (rs2228145) with the clinical course characteristics of hypertrophic cardiomyopathy (HCM) in groups of patients with various cardiometabolic risk factorsMaterial and methods.
T. G. Bezhanishvili, A. Ya. Gudkova, V. G. Davydova, S. E. Andreeva, A. N. Krutikov, E. N. Semernin, B. N. Kudryavtsev, S. A. Pyko, A. A. Kostareva, E. N. Shlyakhto   +9 more
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Co-Occurrence of Interleukin-6 Receptor Asp358Ala Variant and High Plasma Levels of IL-6: An Evidence of IL-6 Trans-Signaling Activation in Deep Vein Thrombosis (DVT) Patients

Biomolecules, 2022
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several mechanisms, and the alteration of IL-6 signaling leads to the overactivation of various processes including immunity, inflammation, and hemostasis.
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido   +7 more
doaj   +1 more source

Serum interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels in South Indian fibromyalgia patients and its correlation with disease severity

Indian Journal of Rheumatology, 2021
Background: Fibromyalgia is a chronic pain syndrome characterized by widespread diffuse pain and multiple tender points along with sleep disturbances, fatigue, and psychological distress.
Sandeep Surendran, C B Mithun, Vishnu S Chandran, Suma Balan, Arun Tiwari   +4 more
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SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody

Vaccines, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has caused more than 4.5 million deaths worldwide.
Collin Jugler, Haiyan Sun, Qiang Chen
doaj   +1 more source

IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation

Frontiers in Immunology, 2022
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases.
Katharina Lambert, Kirsten E. Diggins, Britta E. Jones, Christian Hundhausen, Megan D. Maerz, Anne M. Hocking, Srinath Sanda, Srinath Sanda, Carla J. Greenbaum, Peter S. Linsley, Karen Cerosaletti, Jane H. Buckner   +11 more
doaj   +1 more source

Expression of Interleukin–6 and Interleukin-6 Receptor in Ovine Oocytes During In vitroMaturation

Journal of Integrative Agriculture, 2012
To study the effects of interleukin-6 (IL-6) and its receptor (IL-6R) during in vitro maturation of ovine oocytes, the mRNA and protein expression levels of IL-6 and IL-6R, along with their localization, were examined during ovine oocytes maturation in ...
Xi-an ZHAO, Ming CANG, Xiao-yu GAO, Mei-ling YANG, Jian-long YUAN, Bing ZHU, Zhi-gang WANG, Dong-jun LIU   +7 more
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Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study

Frontiers in Medicine, 2021
Purpose: Emerging evidence suggests a potential role of interleukin-6 pathways—trans-signaling with soluble interleukin-6 receptors—in the asthma pathobiology.
Yoshihiko Raita, Zhaozhong Zhu, Carlos A. Camargo, Robert J. Freishtat, Robert J. Freishtat, Robert J. Freishtat, Debby Ngo, Liming Liang, Liming Liang, Kohei Hasegawa   +9 more
doaj   +1 more source