Results 11 to 20 of about 731,872 (346)

Protected biofactors and antioxidants reduce the negative consequences of virus and cold challenge by modulating immunometabolism via changes in the interleukin-6 receptor signaling cascade in the liver. [PDF]

Poult Sci
Perry F, Johnson CN, Lahaye L, Santin E, Korver DR, Kogut MH, Arsenault RJ.   +6 more
europepmc   +2 more sources

Interleukin-6 receptor polymorphism is prevalent in HIV-negative Castleman Disease and is associated with increased soluble interleukin-6 receptor levels. [PDF]

PLoS ONE, 2013
Multicentric Castleman Disease is largely driven by increased signaling in the pathway for the plasma cell growth factor interleukin-6. We hypothesized that interleukin-6/interleukin-6 receptor/gp130 polymorphisms contribute to increased interleukin-6 ...
Katie Stone, Emily Woods, Susann M Szmania, Owen W Stephens, Tarun K Garg, Bart Barlogie, John D Shaughnessy, Brett Hall, Manjula Reddy, Antje Hoering, Emily Hansen, Frits van Rhee   +11 more
doaj   +1 more source

Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners

Frontiers in Physiology, 2021
Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling.
Paulina Villar-Fincheira, Aaron J. Paredes, Tomás Hernández-Díaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceño, Felipe Contreras-Briceño, Jorge Mandiola, Nicole Bruneau, Lorena García, María Paz Ocaranza, María Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong   +15 more
doaj   +1 more source

Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease [PDF]

Blood, 1991
Interleukin-6 (IL-6) is a multipotent lymphokine that can mediate differentiation of B cells into Ig-secreting cells, stimulate the growth of plasmacytomas, hybridomas, and T cells, and induce acute- phase proteins in liver cells. It has been suggested that IL-6 is involved in the pathogenesis of several diseases by autocrine or paracrine pathways.
M, Jücker, H, Abts, W, Li, R, Schindler, H, Merz, A, Günther, C, von Kalle, M, Schaadt, T, Diamantstein, A C, Feller   +9 more
openaire   +3 more sources

Criteria for the optimal use of interleukin-6 receptor blockers in patients with COVID-19

Терапевтический архив, 2021
Aim. To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes. Materials and methods.
Tatyana S. Kruglova, Darya S. Fomina, Nataliya G. Poteshkina, Nadija F. Frolova, Irina P. Beloglazova, Zinaida Yu. Mutovina, Inna V. Samsonova, Elena A. Kovalevskaja, Alena I. Zagrebneva, Sofya A. Serdotetckova, Anton A. Chernov, Maryana A. Lysenko   +11 more
doaj   +1 more source

Management of patients with rheumatoid arthritis in real clinical practice: Switching from interleukin 6 receptor inhibitors to interleukin 6 inhibitor (olokizumab)

Научно-практическая ревматология, 2023
Aim. Switching to another biologic with the same mode of action provides greater opportunity for long-term management of patients with rheumatoid arthritis (RA).
A. A. Baranov, I. B. Vinogradova, O. N. Anoshenkova, O. V. Antipova, E. A. Bogdanova, Y. Y. Grabovetskaya, E. P. Ilivanova, A. N. Kalyagin, I. N. Kushnir, N. A. Lapkina, M. V. Mokrousova, O. B. Nesmeyanova, N. M. Nikitina, P. A. Shesternya, N. V. Yudina, E. Feist, E. L. Nasonov   +16 more
doaj   +1 more source

Cardiometabolic risk factors and their relationship with the interleukin-6 receptor gene polymorphism (rs2228145) in patients with hypertrophic cardiomyopathy

Российский кардиологический журнал, 2020
Aim. To analyze associations of interleukin-6 receptor gene (IL6R) polymorphism (rs2228145) with the clinical course characteristics of hypertrophic cardiomyopathy (HCM) in groups of patients with various cardiometabolic risk factorsMaterial and methods.
T. G. Bezhanishvili, A. Ya. Gudkova, V. G. Davydova, S. E. Andreeva, A. N. Krutikov, E. N. Semernin, B. N. Kudryavtsev, S. A. Pyko, A. A. Kostareva, E. N. Shlyakhto   +9 more
doaj   +1 more source

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. [PDF]

Proceedings of the National Academy of Sciences, 1993
It has been reported that soluble interleukin (IL)-6 receptor (sIL-6R) is detected in the serum of healthy individuals and its level is increased in patients with multiple myeloma and human immunodeficiency virus infection. Although several reports have suggested that sIL-6R potentiates IL-6 action, its physiological role remains unclear. In this study,
T, Tamura, N, Udagawa, N, Takahashi, C, Miyaura, S, Tanaka, Y, Yamada, Y, Koishihara, Y, Ohsugi, K, Kumaki, T, Taga   +9 more
openaire   +2 more sources

Co-Occurrence of Interleukin-6 Receptor Asp358Ala Variant and High Plasma Levels of IL-6: An Evidence of IL-6 Trans-Signaling Activation in Deep Vein Thrombosis (DVT) Patients

Biomolecules, 2022
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several mechanisms, and the alteration of IL-6 signaling leads to the overactivation of various processes including immunity, inflammation, and hemostasis.
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido   +7 more
doaj   +1 more source

Selective inhibition of interleukin 6 receptor decreased inflammatory cytokines and increased proteases in an experimental model of critical calvarial defect. [PDF]

Braz J Med Biol Res
Melo RCO, Martins AA, Vieira GHA, Andrade RVS, Silva DNA, Chalmers J, Silveira TM, Pirih FQ, Araújo VS, Silva JSP, Lopes MLDS, Leitão RFC, Araújo Júnior RF, Silva ILG, Silva LJT, Barbosa EG, Araújo AA.   +16 more
europepmc   +2 more sources