Results 1 to 10 of about 29,459 (266)

Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice [PDF]

Scientific Reports, 2023
Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation ...
Takafumi Namiki, Jumpei Terakawa, Harumi Karakama, Michiko Noguchi, Hironobu Murakami, Yoshinori Hasegawa, Osamu Ohara, Takiko Daikoku, Junya Ito, Naomi Kashiwazaki   +9 more
doaj   +2 more sources

Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing. [PDF]

PLoS ONE
Effective therapies for retroperitoneal (RP) dedifferentiated liposarcoma (DDLPS) remain unavailable. Loco-regional recurrence occurs in >80% of cases; 5-year disease-specific survival is only 20%. DDLPS is especially prevalent in the retroperitoneum and
Abeba Zewdu, Danielle Braggio, Gonzalo Lopez, Kara Batte, Safiya Khurshid, Fernanda Costas C de Faria, Hemant K Bid, David Koller, Lucia Casadei, Katherine J Ladner, David Wang, Valerie Grignol, O Hans Iwenofu, Dawn Chandler, Denis C Guttridge, Raphael E Pollock   +15 more
doaj   +2 more sources

Bazedoxifene as a Potential Cancer Therapeutic Agent Targeting IL-6/GP130 Signaling [PDF]

Current Oncology
Targeting the interleukin-6 (IL-6)/glycoprotein 130 (GP130) signaling pathway holds significant promise for cancer therapy given its essential role in the survival and progression of various cancer types.
Changyou Shi, Taylor Bopp, Hui-Wen Lo, Katherine Tkaczuk, Jiayuh Lin   +4 more
doaj   +2 more sources

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway,
Lukas Zanders, Melanie Kny, Sebastian Wundersitz   +2 more
exaly   +2 more sources

Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A [PDF]

, 2013
Objective Interleukin (IL)-17A producing CD4 T-cells (TH-17 cells) are implicated in rheumatoid arthritis (RA). IL-6/STAT3 signalling drives TH-17 cell differentiation, and hyperactive gp130/STAT3 signalling in the gp130F/F mouse promotes exacerbated
Greenhill, C. J., Jenkins, B. J., Jones, Gareth Wyn, Jones, S. A., Nowell, Mari Ann, Williams, Anwen Sian, Williams, J. O.   +6 more
core   +3 more sources

Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs [PDF]

Cell Communication and Signaling
Background In the current medical landscape, synthetic cytokine receptors have emerged as a pivotal component in the development of novel therapeutic interventions.
Leorina Kashtanjeva, Christin Ruhland, Franz Christian Horstmeier, Felix Thives-Kurenbach, Julia Ettich, Giacomo Padrini, Sophie Streuber, Jürgen Scheller, Anna Dittrich, Doreen M. Floss   +9 more
doaj   +2 more sources

Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer [PDF]

Molecular Therapy: Nucleic Acids
The pro-inflammatory cytokine interleukin-6 (IL-6) via its IL-6 signal transducer (IL6ST/gp130) plays an important role in neuronal survival, neuro-regeneration, and pathological pain.
Theodora Kalpachidou, Kai Kummer, Valentina Handle, David Zimmermann, Maria Peteinareli, Serena Quarta, Natalia Mach, Laura Castaldi, Paul A. Heppenstall, Rainer V. Haberberger, Hermona Soreq, Michaela Kress   +11 more
doaj   +2 more sources

Fine mapping of heterozygous IL6ST nonsense variants underlying autosomal dominant hyper-IgE syndrome [PDF]

JCI Insight
Loss-of-function (LOF) variants in IL6ST, encoding GP130, can cause hyper-IgE syndrome (HIES). Monoallelic LOF variants in IL6ST lead to HIES when located in the intracellular domain downstream of box 1/2 and upstream of the STAT3 phosphorylation sites ...
Kosuke Ashihara, Takaki Asano, Kanako Takeuchi, Kosuke Noma, Miyuki Tsumura, Wenjie Wang, Wei-Te Lei, Hisao Higo, Toshio Kubo, Yoko Mizoguchi, Shuhei Karakawa, Aurélie Cobat, Clément Conil, Etsushi Toyofuku, Akimasa Sekine, Kohsuke Imai, Dusan Bogunovic, Jean-Laurent Casanova, Cheng-Lung Ku, Vivien Béziat, Satoshi Okada   +20 more
doaj   +2 more sources

PD-L1 autoregulation promotes the proliferation, migration and invasion of glioblastoma cells via GP130/JAK2/STAT3/IRAK2/IL6 signaling pathway. [PDF]

Sci Rep
Xie X, Bai J, Peng Y, Chen P, Zhang Z, Fan D, Zhou F, Yuan Y, Liu J, Zhou Y, Hong Q, Hu J, Duan J, Fu W, Zhang T, Zeng H, Deng J, Dong Y, Liu Y, Qi X, Hong W, He Y, Zhang C, Yu W, Yang Q, Yi W, Bai H, Zhang Q.   +27 more
europepmc   +3 more sources

IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention [PDF]

ImmunoTargets and Therapy
Tim Schumertl, Juliane Lokau, Christoph Garbers Institute of Clinical Biochemistry, Hannover Medical School, Hannover, 30625, GermanyCorrespondence: Christoph Garbers, Institute of Clinical Biochemistry, Hannover Medical School, Carl-Neuberg-Strasse 1 ...
Schumertl T, Lokau J, Garbers C
doaj   +2 more sources