Results 1 to 10 of about 14,761 (132)

Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing. [PDF]

PLoS ONE
Effective therapies for retroperitoneal (RP) dedifferentiated liposarcoma (DDLPS) remain unavailable. Loco-regional recurrence occurs in >80% of cases; 5-year disease-specific survival is only 20%. DDLPS is especially prevalent in the retroperitoneum and
Abeba Zewdu, Danielle Braggio, Gonzalo Lopez, Kara Batte, Safiya Khurshid, Fernanda Costas C de Faria, Hemant K Bid, David Koller, Lucia Casadei, Katherine J Ladner, David Wang, Valerie Grignol, O Hans Iwenofu, Dawn Chandler, Denis C Guttridge, Raphael E Pollock   +15 more
doaj   +2 more sources

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway,
Melanie Kny, Steffen Weber-Carstens, Jens Fielitz   +2 more
exaly   +2 more sources

The Role of gp130 Cytokines in Tuberculosis

Cells, 2020
Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Christoph Hölscher, Hölscher Christoph   +1 more
exaly   +3 more sources

Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs [PDF]

Cell Communication and Signaling
Background In the current medical landscape, synthetic cytokine receptors have emerged as a pivotal component in the development of novel therapeutic interventions.
Leorina Kashtanjeva, Christin Ruhland, Franz Christian Horstmeier, Felix Thives-Kurenbach, Julia Ettich, Giacomo Padrini, Sophie Streuber, Jürgen Scheller, Anna Dittrich, Doreen M. Floss   +9 more
doaj   +2 more sources

Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer [PDF]

Molecular Therapy: Nucleic Acids
The pro-inflammatory cytokine interleukin-6 (IL-6) via its IL-6 signal transducer (IL6ST/gp130) plays an important role in neuronal survival, neuro-regeneration, and pathological pain.
Theodora Kalpachidou, Kai Kummer, Valentina Handle, David Zimmermann, Maria Peteinareli, Serena Quarta, Natalia Mach, Laura Castaldi, Paul A. Heppenstall, Rainer V. Haberberger, Hermona Soreq, Michaela Kress   +11 more
doaj   +2 more sources

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Cell Reports, 2016
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Eva Dimitriadis, Larissa Lamertz, Jürgen Scheller   +2 more
exaly   +3 more sources

Fine mapping of heterozygous IL6ST nonsense variants underlying autosomal dominant hyper-IgE syndrome [PDF]

JCI Insight
Loss-of-function (LOF) variants in IL6ST, encoding GP130, can cause hyper-IgE syndrome (HIES). Monoallelic LOF variants in IL6ST lead to HIES when located in the intracellular domain downstream of box 1/2 and upstream of the STAT3 phosphorylation sites ...
Kosuke Ashihara, Takaki Asano, Kanako Takeuchi, Kosuke Noma, Miyuki Tsumura, Wenjie Wang, Wei-Te Lei, Hisao Higo, Toshio Kubo, Yoko Mizoguchi, Shuhei Karakawa, Aurélie Cobat, Clément Conil, Etsushi Toyofuku, Akimasa Sekine, Kohsuke Imai, Dusan Bogunovic, Jean-Laurent Casanova, Cheng-Lung Ku, Vivien Béziat, Satoshi Okada   +20 more
doaj   +2 more sources

Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation. [PDF]

PLoS ONE, 2012
INTRODUCTION: Bone marrow transplantation (BMT) is a complex process regulated by different cytokines and growth factors. The pleiotropic cytokine IL-6 (Interleukin-6) and related cytokines of the same family acting on the common signal transducer gp130 ...
Daniela C Kroy, Lisa Hebing, Leif E Sander, Nikolaus Gassler, Stephanie Erschfeld, Sara Sackett, Oliver Galm, Christian Trautwein, Konrad L Streetz   +8 more
doaj   +1 more source

Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice

Scientific Reports, 2023
Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation ...
Takafumi Namiki, Jumpei Terakawa, Harumi Karakama, Michiko Noguchi, Hironobu Murakami, Yoshinori Hasegawa, Osamu Ohara, Takiko Daikoku, Junya Ito, Naomi Kashiwazaki   +9 more
doaj   +1 more source

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

Communications Biology, 2023
All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii, Christiane Seibel, Hendrik T. Weitz, Julia Ettich, Anna Rita Minafra, Patrick Petzsch, Alexander Lang, Doreen M. Floss, Kristina Behnke, Karl Köhrer, Jens M. Moll, Jürgen Scheller   +11 more
doaj   +1 more source