Results 1 to 10 of about 15,384 (135)

Interleukin-39 is a Prognostic Biomarker and Therapy Target for Sepsis. [PDF]

Adv Sci (Weinh)
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Zhang FZ, Liu HJ, Yue Y, Gao JJ, Zhang J, Zhang WW, Zhang YL, Lu WH, Jin SW, Zhang PH.   +9 more
europepmc   +2 more sources

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3-CXCL8 Axis. [PDF]

Adv Sci (Weinh)
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Guo W, Qian Z, Wang L, Xu W, Weng Y, Jiang K, Ye Z, Xu J, Song G.   +8 more
europepmc   +2 more sources

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study. [PDF]

J Anat
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Galli C, Colleluori G, Perugini J, Scopini E, Severi I, Grandin G, Giordano A.   +6 more
europepmc   +2 more sources

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Cell Reports, 2016
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Eva Dimitriadis, Larissa Lamertz, Jürgen Scheller   +2 more
exaly   +3 more sources

Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs [PDF]

Cell Communication and Signaling
Background In the current medical landscape, synthetic cytokine receptors have emerged as a pivotal component in the development of novel therapeutic interventions.
Leorina Kashtanjeva, Christin Ruhland, Franz Christian Horstmeier, Felix Thives-Kurenbach, Julia Ettich, Giacomo Padrini, Sophie Streuber, Jürgen Scheller, Anna Dittrich, Doreen M. Floss   +9 more
doaj   +2 more sources

Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation. [PDF]

PLoS ONE, 2012
INTRODUCTION: Bone marrow transplantation (BMT) is a complex process regulated by different cytokines and growth factors. The pleiotropic cytokine IL-6 (Interleukin-6) and related cytokines of the same family acting on the common signal transducer gp130 ...
Daniela C Kroy, Lisa Hebing, Leif E Sander, Nikolaus Gassler, Stephanie Erschfeld, Sara Sackett, Oliver Galm, Christian Trautwein, Konrad L Streetz   +8 more
doaj   +1 more source

Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice

Scientific Reports, 2023
Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation ...
Takafumi Namiki, Jumpei Terakawa, Harumi Karakama, Michiko Noguchi, Hironobu Murakami, Yoshinori Hasegawa, Osamu Ohara, Takiko Daikoku, Junya Ito, Naomi Kashiwazaki   +9 more
doaj   +1 more source

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

Communications Biology, 2023
All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii, Christiane Seibel, Hendrik T. Weitz, Julia Ettich, Anna Rita Minafra, Patrick Petzsch, Alexander Lang, Doreen M. Floss, Kristina Behnke, Karl Köhrer, Jens M. Moll, Jürgen Scheller   +11 more
doaj   +1 more source

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Molecular Neurodegeneration, 2023
Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates.
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler   +10 more
doaj   +1 more source

The role of glycoprotein 130 family of cytokines in fetal rat lung development. [PDF]

PLoS ONE, 2013
The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and oncostatin M (OSM ...
Cristina Nogueira-Silva, Paulina Piairo, Emanuel Carvalho-Dias, Carla Veiga, Rute S Moura, Jorge Correia-Pinto   +5 more
doaj   +1 more source