Results 1 to 10 of about 17,335 (211)
Conditional gp130 deficient mouse mutants
Seminars in Cell and Developmental Biology, 2008 The common cytokine receptor chain, gp130, controls the activity of a group of cytokines, namely, IL-6, IL-11, IL-27, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like ...
Werner Müller
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Frontiers in Immunology, 2018 gp130 cytokines are differentially involved in regulating the T helper (H) 17-driven pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of human multiple sclerosis.
Marco Prinz +2 more
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Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice [PDF]
Scientific Reports, 2023 Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation ...
Takafumi Namiki +9 more
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Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation. [PDF]
PLoS ONE, 2012 INTRODUCTION: Bone marrow transplantation (BMT) is a complex process regulated by different cytokines and growth factors. The pleiotropic cytokine IL-6 (Interleukin-6) and related cytokines of the same family acting on the common signal transducer gp130 ...
Daniela C Kroy +8 more
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The Role of gp130 Cytokines in Tuberculosis [PDF]
Cells, 2020 Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter +2 more
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gp130 at the nexus of inflammation, autoimmunity, and cancer [PDF]
Journal of Leukocyte Biology, 2010 Review highlights the function of the cytokine receptor gp130, specifically the diverse roles it plays in inflammation, autoimmunity, and cancer.
C A Hunter, J S Silver
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GP130 activation induces myeloma and collaborates with MYC. [PDF]
Journal of Clinical Investigation, 2014 Multiple myeloma (MM) is a plasma cell neoplasm that results from clonal expansion of an Ig-secreting terminally differentiated B cell. Advanced MM is characterized by tissue damage that involves bone, kidney, and other organs and is typically associated
Dechow, Tobias;Steidle, Sabine;Götze, Katharina S;Rudelius, Martina;Behnke, Kerstin;Pechloff, Konstanze;Kratzat, Susanne;Bullinger, Lars;Fend, Falko;Soberon, Valeria;Mitova, Nadya;Li, Zhoulei;Thaler, Markus;Bauer, Jan;Pietschmann, Elke;Albers, Corinna;Grundler, Rebekka;Schmidt-Supprian, Marc;Ruland, Jürgen;Peschel, Christian;Duyster, Justus;Rose-John, Stefan;Bassermann, Florian;Keller, Ulrich
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The two facets of gp130 signalling in liver tumorigenesis [PDF]
Seminars in Immunopathology, 2021 The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers.
Galun, Eithan +2 more
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Cross-talk among gp130 Cytokines in Adipocytes [PDF]
Journal of Biological Chemistry, 2005 The interleukin-6 (IL-6) family of cytokines is a family of structurally and functionally related proteins, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1). These
Patricia Arbour-Reily +9 more
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Scientific ReportsThe aim of the present study was to investigate the effects of Oncostatin M receptor (OSMR) subunit gp130 knockdown on insulin-stimulated glucose metabolism-related signaling pathways and glucose uptake in skeletal muscle cells.
Koji Sato
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