Results 11 to 20 of about 18,703 (209)

The Role of gp130 Cytokines in Tuberculosis [PDF]

Cells, 2020
Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter, Jasmin Rousseau, Christoph Hölscher   +2 more
doaj   +3 more sources

Conditional gp130 deficient mouse mutants

Seminars in Cell & Developmental Biology, 2008
The common cytokine receptor chain, gp130, controls the activity of a group of cytokines, namely, IL-6, IL-11, IL-27, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC) and neuropoietin (NPN).
Fasnacht, Nicolas, Müller, Werner; id_orcid 0000-0002-1297-9725   +1 more
openaire   +3 more sources

gp130 at the nexus of inflammation, autoimmunity, and cancer [PDF]

Journal of Leukocyte Biology, 2010
Abstract Review highlights the function of the cytokine receptor gp130, specifically the diverse roles it plays in inflammation, autoimmunity, and cancer. Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM ...
J S, Silver, C A, Hunter
openaire   +3 more sources

Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells

Scientific Reports
The aim of the present study was to investigate the effects of Oncostatin M receptor (OSMR) subunit gp130 knockdown on insulin-stimulated glucose metabolism-related signaling pathways and glucose uptake in skeletal muscle cells.
Koji Sato
doaj   +3 more sources

A structural template for gp130-cytokine signaling assemblies [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
The gp130-cytokine system has been fertile ground for protein structure-function studies aimed at elucidating the basis of ligand recognition and receptor activation. A number of longstanding questions involve the mechanism of the stepwise assembly of the active signaling complexes, as well as the structure of the gp130-cytokine complexes.
Chow, Dar-chone, Brevnova, Lena, He, Xiao-lin, Martick, Monika M, Bankovich, Alex, Garcia, K.Christopher   +5 more
openaire   +3 more sources

Synthetic Mimetics of the gp130 Binding Site for Viral Interleukin‐6 as Inhibitors of the vIL‐6–gp130 Interaction

Chemical Biology & Drug Design, 2008
The transmembrane protein gp130 acts as the signal transducing receptor subunit for interleukin‐6 type cytokines, including viral interleukin‐6, which is encoded by the Kaposi’s sarcoma‐associated herpes virus. Viral interleukin‐6 has been shown to mimic human IL‐6 functions, including activation of the JAK1 and STAT1/3 signaling pathways. Based on the
Sudarman, Enge, Bollati-Fogolín, Mariela, Hafner, Martin, Müller, Werner; id_orcid 0000-0002-1297-9725, Scheller, Jürgen, Rose-John, Stefan, Eichler, Jutta   +6 more
openaire   +3 more sources

Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation

, 2008
IL-6 is known to play a crucial role in the pathogenesis of chronic intestinal inflammation by modulating T cell functions. In this study, we investigated the role of gp130, the common signal transducer for all IL-6 cytokines, in a murine model of acute ...
Sander, Leif E., Streetz, Konrad L., Dierssen, Uta, Obermeier, Florian, Tacke, Frank, Singh, Anurag K., Müller, Werner; id_orcid, Lutz, Holger H., Trautwein, Christian, Seidler, Ursula, Kroy, Daniela C.   +10 more
core   +11 more sources

Transactivation of gp130 in Myeloma Cells [PDF]

The Journal of Immunology, 2003
Abstract Receptor transactivation, i.e., interaction between unrelated receptor systems, is a growing theme in cytokine and growth factor signaling. In this study we reveal for the first time the ability of IFN-α to transactivate gp130 in myeloma cells. An epidermal growth factor receptor/gp130 chimeric receptor previously shown by us
Jena D, French, Denise K, Walters, Diane F, Jelinek   +2 more
openaire   +2 more sources

Effect of (−)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A

Toxins, 2021
Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. Gp130 activates intracellular signaling pathways, including the Janus kinase/signal transducers and activators of transcription (JAK/STAT ...
Yuko Shimamura, Rina Noaki, Ami Kurokawa, Mio Utsumi, Chikako Hirai, Toshiyuki Kan, Shuichi Masuda   +6 more
doaj   +1 more source

Gp130-dependent signaling in the podocyte [PDF]

American Journal of Physiology-Renal Physiology, 2014
Renal inflammation, in particular glomerular, is often characterized by increased IL-6 levels. The in vivo relevance of IL-6 signaling in glomerular podocytes, which play central roles in most glomerular diseases, is unknown. Here, we show that in normal mice, podocytes express gp130, the common signal-transducing receptor subunit of the IL-6 family of
Yoshikuni, Nagayama, Gerald S, Braun, Christina M, Jakobs, Yuichi, Maruta, Claudia R, van Roeyen, Barbara M, Klinkhammer, Peter, Boor, Luigi, Villa, Ute, Raffetseder, Christian, Trautwein, Dieter, Görtz, Gerhard, Müller-Newen, Tammo, Ostendorf, Jürgen, Floege   +13 more
openaire   +2 more sources