Results 11 to 20 of about 17,335 (211)

Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing. [PDF]

PLoS ONE
Effective therapies for retroperitoneal (RP) dedifferentiated liposarcoma (DDLPS) remain unavailable. Loco-regional recurrence occurs in >80% of cases; 5-year disease-specific survival is only 20%. DDLPS is especially prevalent in the retroperitoneum and
Abeba Zewdu, Danielle Braggio, Gonzalo Lopez, Kara Batte, Safiya Khurshid, Fernanda Costas C de Faria, Hemant K Bid, David Koller, Lucia Casadei, Katherine J Ladner, David Wang, Valerie Grignol, O Hans Iwenofu, Dawn Chandler, Denis C Guttridge, Raphael E Pollock   +15 more
doaj   +2 more sources

GP130 Antagonism Enhances Porcine RV Function [PDF]

Circulation Research
BACKGROUND: Right ventricular (RV) dysfunction is a risk factor for death in multiple cardiovascular diseases, but RV-enhancing therapies are lacking. Inhibition of GP130 (glycoprotein-130) signaling with the small molecule SC144 improves RV function in rodent RV dysfunction via anti-inflammatory and metabolic ...
Jenna B. Mendelson, Jacob D. Sternbach, Minwoo Kim, Ryan A. Moon, Lynn M. Hartweck, Sophia R. Clark, Walt Tollison, Matthew T. Lahti, John P. Carney, Todd Markowski, LeeAnn Higgins, Felipe Kazmirczak, Kurt W. Prins   +12 more
openaire   +3 more sources

Crystal structure of a cytokine-binding region of gp130 [PDF]

EMBO Journal, 1998
The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily.
Jeronimo Bravo, David Staunton, John K Heath   +2 more
exaly   +4 more sources

Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs [PDF]

Cell Communication and Signaling
Background In the current medical landscape, synthetic cytokine receptors have emerged as a pivotal component in the development of novel therapeutic interventions.
Leorina Kashtanjeva, Christin Ruhland, Franz Christian Horstmeier, Felix Thives-Kurenbach, Julia Ettich, Giacomo Padrini, Sophie Streuber, Jürgen Scheller, Anna Dittrich, Doreen M. Floss   +9 more
doaj   +2 more sources

Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction

Chemical Biology & Drug Design, 2008
The transmembrane protein gp130 acts as the signal transducing receptor subunit for interleukin-6 type cytokines, including viral interleukin-6, which is encoded by the Kaposi's sarcoma-associated herpes virus. Viral interleukin-6 has been shown to mimic
Sudarman, Enge, Bollati-Fogolín, Mariela, Scheller, Jürgen, Müller, Werner; id_orcid, Eichler, Jutta, Rose-John, Stefan, Hafner, Martin   +6 more
core   +3 more sources

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Cell Reports, 2016
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Jens M Moll, Carly Cuman, Larissa Lamertz   +2 more
exaly   +3 more sources

A structural template for gp130-cytokine signaling assemblies

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
The gp130-cytokine system has been fertile ground for protein structure–function studies aimed at elucidating the basis of ligand recognition and receptor activation.
Garcia, K.Christopher, Xiao-lin He, Chow, Dar-chone, Lena Brevnova, Alex Bankovich, Brevnova, Lena, He, Xiao-lin, K.Christopher Garcia, Dar-chone Chow, Monika M Martick, Martick, Monika M, Bankovich, Alex   +11 more
core   +3 more sources

Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer [PDF]

Molecular Therapy: Nucleic Acids
The pro-inflammatory cytokine interleukin-6 (IL-6) via its IL-6 signal transducer (IL6ST/gp130) plays an important role in neuronal survival, neuro-regeneration, and pathological pain.
Theodora Kalpachidou, Kai Kummer, Valentina Handle, David Zimmermann, Maria Peteinareli, Serena Quarta, Natalia Mach, Laura Castaldi, Paul A. Heppenstall, Rainer V. Haberberger, Hermona Soreq, Michaela Kress   +11 more
doaj   +2 more sources

The dynamics of signal triggering in a gp130-receptor complex.

Structure, 2007
gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the ...
Jones, Edith, Fuller, Stephen, Heath, John, Fuller, S, Jones, EY, Matadeen, Rishi, Heath, John K., Jones, E. Yvonne, Hon, WC, Hon, Wai-Ching, Matadeen, R, Heath, JK   +11 more
core   +3 more sources

Fine mapping of heterozygous IL6ST nonsense variants underlying autosomal dominant hyper-IgE syndrome [PDF]

JCI Insight
Loss-of-function (LOF) variants in IL6ST, encoding GP130, can cause hyper-IgE syndrome (HIES). Monoallelic LOF variants in IL6ST lead to HIES when located in the intracellular domain downstream of box 1/2 and upstream of the STAT3 phosphorylation sites ...
Kosuke Ashihara, Takaki Asano, Kanako Takeuchi, Kosuke Noma, Miyuki Tsumura, Wenjie Wang, Wei-Te Lei, Hisao Higo, Toshio Kubo, Yoko Mizoguchi, Shuhei Karakawa, Aurélie Cobat, Clément Conil, Etsushi Toyofuku, Akimasa Sekine, Kohsuke Imai, Dusan Bogunovic, Jean-Laurent Casanova, Cheng-Lung Ku, Vivien Béziat, Satoshi Okada   +20 more
doaj   +2 more sources