Results 11 to 20 of about 29,459 (266)
The Role of gp130 Cytokines in Tuberculosis [PDF]
Cells, 2020 Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter +2 more
doaj +4 more sources
Cross-talk among gp130 Cytokines in Adipocytes [PDF]
Journal of Biological Chemistry, 2005 The interleukin-6 (IL-6) family of cytokines is a family of structurally and functionally related proteins, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1). These proteins are also known as gp130 cytokines because they all share gp130 as a common transducer ...
Sanjin Zvonic +4 more
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Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation. [PDF]
PLoS ONE, 2012 INTRODUCTION: Bone marrow transplantation (BMT) is a complex process regulated by different cytokines and growth factors. The pleiotropic cytokine IL-6 (Interleukin-6) and related cytokines of the same family acting on the common signal transducer gp130 ...
Daniela C Kroy +8 more
doaj +1 more source
Communications Biology, 2023 All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii +11 more
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Molecular Neurodegeneration, 2023 Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates.
Stephan A. Müller +10 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
The role of glycoprotein 130 family of cytokines in fetal rat lung development. [PDF]
PLoS ONE, 2013 The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and oncostatin M (OSM ...
Cristina Nogueira-Silva +5 more
doaj +1 more source
Toxins, 2021 Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. Gp130 activates intracellular signaling pathways, including the Janus kinase/signal transducers and activators of transcription (JAK/STAT ...
Yuko Shimamura +6 more
doaj +1 more source
gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis
Biomedicines, 2023 Obesity is the main cause of metabolic complications. Fatty liver infiltration is a companion of obesity. NAFLD is associated with impaired energy metabolism with an excess of nutrients.
Daria Shunkina +8 more
doaj +1 more source
Transactivation of gp130 in Myeloma Cells [PDF]
The Journal of Immunology, 2003 Abstract Receptor transactivation, i.e., interaction between unrelated receptor systems, is a growing theme in cytokine and growth factor signaling. In this study we reveal for the first time the ability of IFN-α to transactivate gp130 in myeloma cells. An epidermal growth factor receptor/gp130 chimeric receptor previously shown by us to
Jena D, French +2 more
openaire +2 more sources