Results 41 to 50 of about 29,459 (266)

Osteoclasts Are Present in gp130-Deficient Mice* [PDF]

Endocrinology, 1997
Interleukin (IL)-6, IL-11, leukemia inhibitory factor, and oncostatin M similarly induce osteoclast formation in cocultures of osteoblastic cells and bone marrow cells. These cytokines share a common signal transducer, gp130, which forms a receptor complex with the specific receptor for each cytokine.
K, Kawasaki, Y H, Gao, S, Yokose, Y, Kaji, T, Nakamura, T, Suda, K, Yoshida, T, Taga, T, Kishimoto, H, Kataoka, T, Yuasa, H, Norimatsu, A, Yamaguchi   +12 more
openaire   +2 more sources

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice [PDF]

, 2015
Duchenne muscular dystrophy (DMD) is characterized by progressive lethal muscle degeneration and chronic inflammatory response. The mdx mouse strain has served as the animal model for human DMD. However, while DMD patients undergo extensive necrosis, the
Berardinelli, Maria Grazia, Camilli, Carlotta, Catizone, Angela, De Benedetti, Fabrizio, Forcina, Laura, Musarò, Antonio, Nicoletti, Carmine, Pelosi, Laura, Rizzuto, Emanuele, Spelta, Elisa, Testa, Erika   +10 more
core   +2 more sources

Oncostatin M induces heat hypersensitivity by gp130-dependent sensitization of TRPV1 in sensory neurons

Molecular Pain, 2011
Oncostatin M (OSM) is a member of the interleukin-6 cytokine family and regulates eg. gene activation, cell survival, proliferation and differentiation. OSM binds to a receptor complex consisting of the ubiquitously expressed signal transducer gp130 and ...
Langeslag Michiel, Constantin Cristina E, Andratsch Manfred, Quarta Serena, Mair Norbert, Kress Michaela   +5 more
doaj   +1 more source

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

PLoS Biology, 2016
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood.
Benjamin M Laitman, Linnéa Asp, John N Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A Braun, Q Richard Lu, Goutham Narla, Cedric S Raine, Scott L Friedman, Patrizia Casaccia, Gareth R John   +23 more
doaj   +1 more source

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

Nature Communications, 2023
Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into ...
Riley D. Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C. Kosasih, Courtney O. Zlatic, Larissa Doughty, Craig J. Morton, Andrew P. Leis, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin   +12 more
doaj   +1 more source

CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2 and gp130 in CD3+CD4+, CD3 ...
Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Aziz Farah Izati, Aziz Farah Izati, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]

, 2017
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien, De Cauwer, Lode, Icardi, Laura, Mori, Raffaele, Peelman, Frank, Tavernier, Jan, Van Der Heyden, José, Wauman, Joris   +7 more
core   +3 more sources

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. [PDF]

, 2017
Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation ...
Chwa, Marilyn, Cohen, Pinchas, Kenney, M Cristina, Kuppermann, Baruch D, Lu, Stephanie, Nashine, Sonali, Nesburn, Anthony B   +6 more
core   +1 more source

gp130's sensitive side [PDF]

Science-Business eXchange, 2009
Medical University Innsbruck researchers suggest that inhibiting the gp130 pathway could help manage certain types of pain as well as exert a therapeutic effect in cancer and inflammation. The key will be to block the pathway without disrupting the body's natural immune response.
openaire   +1 more source