Results 41 to 50 of about 18,703 (209)

Oncostatin M induces heat hypersensitivity by gp130-dependent sensitization of TRPV1 in sensory neurons

Molecular Pain, 2011
Oncostatin M (OSM) is a member of the interleukin-6 cytokine family and regulates eg. gene activation, cell survival, proliferation and differentiation. OSM binds to a receptor complex consisting of the ubiquitously expressed signal transducer gp130 and ...
Langeslag Michiel, Constantin Cristina E, Andratsch Manfred, Quarta Serena, Mair Norbert, Kress Michaela   +5 more
doaj   +1 more source

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

Nature Communications, 2023
Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into ...
Riley D. Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C. Kosasih, Courtney O. Zlatic, Larissa Doughty, Craig J. Morton, Andrew P. Leis, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin   +12 more
doaj   +1 more source

Purification of a synthetic GFP-GFP-mCherry-Fc cytokine and analysis of signal transduction induced through GFP_VHH-gp130 and mCherry_VHH-gp130 SyCyRs.

, 2020
(A) Schematic illustration of a GFP-GFP-mCherry fusion protein covalently linked to the Fc domain of an IgG antibody. The Fc domain forms a dimer and this leads to a hexameric GFP-GFP-mCherry assembly with two mCherry proteins in the center and two GFP ...
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

PLoS Biology, 2016
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood.
Benjamin M Laitman, Linnéa Asp, John N Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A Braun, Q Richard Lu, Goutham Narla, Cedric S Raine, Scott L Friedman, Patrizia Casaccia, Gareth R John   +23 more
doaj   +1 more source

Cross-talk among gp130 Cytokines in Adipocytes [PDF]

, 2005
The interleukin-6 (IL-6) family of cytokines is a family of structurally and functionally related proteins, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1). These
Patricia Arbour-Reily, Randall L. Mynatt, Jacqueline M. Stephens, Baugh, James E., Stephens, Jacqueline M., James E. Baugh, Arbour-Reily, Patricia, Sanjin Zvonic, Zvonic, Sanjin, Mynatt, Randall L.   +9 more
core   +1 more source

CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2 and gp130 in CD3+CD4+, CD3 ...
Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Aziz Farah Izati, Aziz Farah Izati, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

GP130 activation induces myeloma and collaborates with MYC.

, 2014
Multiple myeloma (MM) is a plasma cell neoplasm that results from clonal expansion of an Ig-secreting terminally differentiated B cell. Advanced MM is characterized by tissue damage that involves bone, kidney, and other organs and is typically associated
Dechow, Tobias;Steidle, Sabine;Götze, Katharina S;Rudelius, Martina;Behnke, Kerstin;Pechloff, Konstanze;Kratzat, Susanne;Bullinger, Lars;Fend, Falko;Soberon, Valeria;Mitova, Nadya;Li, Zhoulei;Thaler, Markus;Bauer, Jan;Pietschmann, Elke;Albers, Corinna;Grundler, Rebekka;Schmidt-Supprian, Marc;Ruland, Jürgen;Peschel, Christian;Duyster, Justus;Rose-John, Stefan;Bassermann, Florian;Keller, Ulrich
core   +2 more sources

Characterization of a gp130 Signaling Receptor Polymorphism [PDF]

, 2013
We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core  

Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model

The Scientific World Journal, 2006
Interleukin-6 (IL-6) affects the survival and proliferation of myeloma cells via autocrine and/or paracrine mechanisms. In this study, we investigated the effects of IL-6, IL-6 receptor antagonist (IL-6RA), and gp130 antagonist (gp130A) on the membrane ...
Eva Kovacs
doaj   +1 more source

The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients

Frontiers in Aging Neuroscience, 2019
These days, the important role of retinoids in adult brain functionality and homeostasis is well accepted and has been proven by genomic as well as non-genomic mechanisms.
Malena dos Santos Guilherme, Nicolai M. Stoye, Stefan Rose-John, Christoph Garbers, Andreas Fellgiebel, Kristina Endres   +5 more
doaj   +1 more source