Results 41 to 50 of about 17,335 (211)

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells

Frontiers in Immunology, 2019
The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies have demonstrated ...
Khalid Bin Dhuban, Khalid Bin Dhuban, Khalid Bin Dhuban, Sabrina Bartolucci, Sabrina Bartolucci, Sabrina Bartolucci, Eva d'Hennezel, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo   +9 more
doaj   +1 more source

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

Cancer Medicine, 2022
Background Nerve invasion (N‐inv) is an important prognostic factor in pancreatic ductal adenocarcinoma (PDAC). Elucidation of circulating N‐inv stimulators could provide deeper insights and novel perspectives for PDAC therapy.
Hidetaka Suzuki, Shuichi Mitsunaga, Masafumi Ikeda, Takao Aoyama, Kazumi Yoshizawa, Masayuki Yamaguchi, Masami Suzuki, Minoru Narita, Toshikatsu Kawasaki, Atsushi Ochiai   +9 more
doaj   +1 more source

Purification of synthetic GFP-mCherry-Fc and analysis of signal transduction induced through GFP_VHH-gp130 and mCherry_VHH-gp130 SyCyRs.

, 2020
(A) Schematic illustration of a GFP-mCherry fusion protein linked to the Fc domain of an IgG antibody. The Fc domain forms a dimer leading to a tetrameric assembly with two central mCherry proteins and GFP subunits on the outside.
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

Oncostatin M induces heat hypersensitivity by gp130-dependent sensitization of TRPV1 in sensory neurons

Molecular Pain, 2011
Oncostatin M (OSM) is a member of the interleukin-6 cytokine family and regulates eg. gene activation, cell survival, proliferation and differentiation. OSM binds to a receptor complex consisting of the ubiquitously expressed signal transducer gp130 and ...
Langeslag Michiel, Constantin Cristina E, Andratsch Manfred, Quarta Serena, Mair Norbert, Kress Michaela   +5 more
doaj   +1 more source

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

Nature Communications, 2023
Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into ...
Riley D. Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C. Kosasih, Courtney O. Zlatic, Larissa Doughty, Craig J. Morton, Andrew P. Leis, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin   +12 more
doaj   +1 more source

Purification of a synthetic GFP-GFP-mCherry-Fc cytokine and analysis of signal transduction induced through GFP_VHH-gp130 and mCherry_VHH-gp130 SyCyRs.

, 2020
(A) Schematic illustration of a GFP-GFP-mCherry fusion protein covalently linked to the Fc domain of an IgG antibody. The Fc domain forms a dimer and this leads to a hexameric GFP-GFP-mCherry assembly with two mCherry proteins in the center and two GFP ...
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

PLoS Biology, 2016
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood.
Benjamin M Laitman, Linnéa Asp, John N Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A Braun, Q Richard Lu, Goutham Narla, Cedric S Raine, Scott L Friedman, Patrizia Casaccia, Gareth R John   +23 more
doaj   +1 more source

CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2 and gp130 in CD3+CD4+, CD3 ...
Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Aziz Farah Izati, Aziz Farah Izati, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

, 2010
Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation.
Beraza, N., Linke, Reinhold P, Dierssen, U., Magarian Blander, J., Magarian Blander, Julie, Linke, R., Müller, M.R., Sander, Leif E., Leif E. Sander, Sander, L.E., Christian Trautwein, Dierssen, Uta, Trautwein, Christian, Sara Dutton Sackett, Sander, Leif Erik, Reinhold P. Linke, Müller, Michael, Tacke, F., Dutton Sackett, Sara, Tacke, Frank, Beraza, Naiara, Blander, J Magarian, Michael Müller, Uta Dierssen, Naiara Beraza, Frank Tacke, Sackett, S.D., Sackett, Sara Dutton, Blander, J.M., Trautwein, C., Sander, Leif E, J. Magarian Blander, Linke, Reinhold P.   +32 more
core   +1 more source

Gp130 is expressed in pancreatic cancer and can be targeted by the small inhibitor molecule SC144 [PDF]

, 2022
PURPOSE: Interleukin 6 (IL-6), Oncostatin M (OSM), and downstream effector STAT3 are pro-tumorigenic agents in pancreatic ductal adenocarcinoma (PDAC).
Arndt, Marco, Bruns, Christiane J., Beyer, Katharina, Pozios, Ioannis, Hering, Nina A., Guenzler, Emily, Elezkurtaj, Sefer, Margonis, Georgios A., Seeliger, Hendrik, Knösel, Thomas   +9 more
core   +1 more source