Results 1 to 10 of about 11,604 (173)

Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies [PDF]

Frontiers in Immunology
IntroductionAlthough Interleukin (IL)-6-type cytokine signaling is critical for maintaining the body's homeostasis, aberrant signaling has been observed in numerous diseases including autoimmunity and cancer.
Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller   +12 more
doaj   +2 more sources

Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs [PDF]

Cell Communication and Signaling
Background In the current medical landscape, synthetic cytokine receptors have emerged as a pivotal component in the development of novel therapeutic interventions.
Leorina Kashtanjeva, Christin Ruhland, Franz Christian Horstmeier, Felix Thives-Kurenbach, Julia Ettich, Giacomo Padrini, Sophie Streuber, Jürgen Scheller, Anna Dittrich, Doreen M. Floss   +9 more
doaj   +2 more sources

iBody-mediated tuning of synthetic cytokine receptor activation via rational nanobody interface engineering [PDF]

mAbs
Nanobodies are small, single-domain antibody fragments derived from heavy chain-only antibodies. They combine high binding affinity with advantages such as compact size, stability, solubility, and flexible epitope recognition, making them attractive ...
Richard Kunze, Fabian Navratil, Joana Beichert, Felix Geyer, Doreen M. Floss, Harald Kolmar, Jürgen Scheller, Silke Pudewell   +7 more
doaj   +2 more sources

Development of a trispecific fusion protein based on angiotensin-converting enzyme 2, glycoprotein 130, and tumor necrosis factor receptor 2 as a promising therapeutic for COVID-19 [PDF]

Molecular Biomedicine
Despite a substantial reduction in the incidence of coronavirus disease 2019 (COVID-19) infections, severe cases continue to pose a significant clinical burden, particularly among elderly individuals and patients with underlying medical conditions, due ...
Yongfeng Qiao, Yanjun Han, Lu Zhao, Wenjing Gao, Hong Hu, Chao Su, Anqi Zheng, Junqing Sun, Mingxiong Tian, Yarong Wu, Lianmei Bai, Yuping Lei, Jiahao Wu, Weibing Zhang, Pu Han, Xiaoyu Li, Chunbo Dong, Haidong Wang, Zhida Liu, Pengcheng Han   +19 more
doaj   +2 more sources

IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention [PDF]

ImmunoTargets and Therapy
Tim Schumertl, Juliane Lokau, Christoph Garbers Institute of Clinical Biochemistry, Hannover Medical School, Hannover, 30625, GermanyCorrespondence: Christoph Garbers, Institute of Clinical Biochemistry, Hannover Medical School, Carl-Neuberg-Strasse 1 ...
Schumertl T, Lokau J, Garbers C
doaj   +2 more sources

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

Communications Biology, 2023
All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii, Christiane Seibel, Hendrik T. Weitz, Julia Ettich, Anna Rita Minafra, Patrick Petzsch, Alexander Lang, Doreen M. Floss, Kristina Behnke, Karl Köhrer, Jens M. Moll, Jürgen Scheller   +11 more
doaj   +1 more source

Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors

iScience, 2021
Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner, Doreen Manuela Floss, Jürgen Scheller   +2 more
doaj   +1 more source

The role of glycoprotein 130 family of cytokines in fetal rat lung development. [PDF]

PLoS ONE, 2013
The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and oncostatin M (OSM ...
Cristina Nogueira-Silva, Paulina Piairo, Emanuel Carvalho-Dias, Carla Veiga, Rute S Moura, Jorge Correia-Pinto   +5 more
doaj   +1 more source

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

Nature Communications, 2023
Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into ...
Riley D. Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C. Kosasih, Courtney O. Zlatic, Larissa Doughty, Craig J. Morton, Andrew P. Leis, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin   +12 more
doaj   +1 more source

Effect of (−)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A

Toxins, 2021
Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. Gp130 activates intracellular signaling pathways, including the Janus kinase/signal transducers and activators of transcription (JAK/STAT ...
Yuko Shimamura, Rina Noaki, Ami Kurokawa, Mio Utsumi, Chikako Hirai, Toshiyuki Kan, Shuichi Masuda   +6 more
doaj   +1 more source