The role of IL-11 in chronic diseases [PDF]
Frontiers in ImmunologyBackgroundInitially recognized for its role in hematopoiesis, Interleukin-11 (IL-11) is now understood to possess a wide spectrum of biological activities.
Jingxuan Zhang +5 more
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Roles of IL-11 in the regulation of bone metabolism [PDF]
Frontiers in Endocrinology, 2023 Bone metabolism is the basis for maintaining the normal physiological state of bone, and imbalance of bone metabolism can lead to a series of metabolic bone diseases.
Yijing Han +5 more
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Effects of IL-11/IL-11 Receptor Alpha on Proliferation and Steroidogenesis in Ovarian Granulosa Cells of Dairy Cows [PDF]
Cells, 2023 Granulosa cells (GCs) are essential for follicular growth, oocyte maturation, and steroidogenesis in the ovaries. Interleukin (IL)-11 is known to play a crucial role in the decidualization of the uterus, however, the expression of the IL-11 system (IL-11,
Hanxiao Wu +8 more
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Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases [PDF]
Biomedicines, 2021 Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher ...
Paola Maroni +3 more
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Ameliorating post-infarction myocardial fibrosis and cardiac function via ROS-responsive hydrogel-mediated IL-11 antibody delivery [PDF]
Bioactive MaterialsMyocardial fibrosis, driven by fibroblast activation following myocardial infarction (MI), represents a significant pathological process contributing to heart failure progression.
Ting You +22 more
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The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review [PDF]
Journal of Cardiovascular Development and DiseaseFibrosis is one of the main factors that impair the function of many organs. In the heart, fibrosis leads to contractile dysfunction and arrhythmias, which are important in the development of heart failure.
Yarlla Loyane Lira Braga +8 more
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IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis [PDF]
Respiratory Research, 2022 Background Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we analyzed the contribution of IL-11
Javier Milara +5 more
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IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy [PDF]
Frontiers in Endocrinology, 2022 Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in various inflammatory and autoimmune diseases. However, the expression
Pengsen Wu +9 more
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Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis [PDF]
Molecular MedicineReduced lymphoid enhancer-binding factor 1 (LEF1) expression in patients with adenomyosis during the mid-secretory phase leads to impaired endometrial receptivity, affecting embryo implantation. This study investigated the molecular mechanisms underlying
Jingru Duan +8 more
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Interleukin-11/IL-11 Receptor Promotes Glioblastoma Cell Proliferation, Epithelial–Mesenchymal Transition, and Invasion [PDF]
Brain SciencesGlioblastoma is highly proliferative and invasive. However, the regulatory cytokine networks that promote glioblastoma cell proliferation and invasion into other areas of the brain are not fully defined.
Sarah F. Stuart +9 more
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