Roles of IL-11 in the regulation of bone metabolism [PDF]
Frontiers in Endocrinology, 2023 Bone metabolism is the basis for maintaining the normal physiological state of bone, and imbalance of bone metabolism can lead to a series of metabolic bone diseases.
Yijing Han +5 more
doaj +5 more sources
The role of IL-11 in chronic diseases [PDF]
Frontiers in ImmunologyBackgroundInitially recognized for its role in hematopoiesis, Interleukin-11 (IL-11) is now understood to possess a wide spectrum of biological activities.
Jingxuan Zhang +5 more
doaj +4 more sources
Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases [PDF]
Biomedicines, 2021 Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher ...
Paola Maroni +3 more
doaj +3 more sources
IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis [PDF]
Respiratory Research, 2022 Background Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we analyzed the contribution of IL-11
Javier Milara +5 more
doaj +3 more sources
Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling. [PDF]
FASEB J, 2021 Interleukin‐11 (IL‐11) is a pleiotropic cytokine with both pro‐ and anti‐inflammatory properties. It activates its target cells via binding to the membrane‐bound IL‐11 receptor (IL‐11R), which then recruits a homodimer of the ubiquitously expressed ...
Koch L +7 more
europepmc +9 more sources
IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy [PDF]
Frontiers in Endocrinology, 2022 Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in various inflammatory and autoimmune diseases. However, the expression
Pengsen Wu +9 more
doaj +3 more sources
Effects of IL-11/IL-11 Receptor Alpha on Proliferation and Steroidogenesis in Ovarian Granulosa Cells of Dairy Cows [PDF]
Cells, 2023 Granulosa cells (GCs) are essential for follicular growth, oocyte maturation, and steroidogenesis in the ovaries. Interleukin (IL)-11 is known to play a crucial role in the decidualization of the uterus, however, the expression of the IL-11 system (IL-11,
Hanxiao Wu +8 more
doaj +4 more sources
The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine. [PDF]
Aging Dis, 2023 Interleukin-(IL)-11 is a cytokine involved in hematopoiesis, cancer metastasis, and inflammation. IL-11 belongs to the IL-6 cytokine family, binding to the complex of receptors glycoprotein gp130 and the ligand-specific-receptor subunits (IL-11Rα or ...
Dong B +7 more
europepmc +2 more sources
IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance This study examines how interleukin (IL)-11 regulates inflammatory cell trafficking to the CNS in RRMS (relapsing–remitting multiple sclerosis).
Seyedsadr M +19 more
europepmc +2 more sources
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. [PDF]
NatureFor healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1–7. Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated ...
Widjaja AA +25 more
europepmc +2 more sources