Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer [PDF]
Cells, 2022 Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer and is a fast progressive disease when left untreated. Identification of potential biomarkers in NSCLC is an ongoing area of research that aims to detect, diagnose, and prognosticate ...
Jason Hongting Leung +2 more
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Interleukin-11 disrupts alveolar epithelial progenitor function [PDF]
ERJ Open Research, 2023 Background Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates their excessive collagen deposition in the lung.
Rosa K. Kortekaas +7 more
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Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice [PDF]
iScience, 2023 Summary: Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases.
Takashi Nishina +6 more
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Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases [PDF]
Biomedicines, 2021 Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher ...
Paola Maroni +3 more
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion [PDF]
Clinical and Translational MedicineRationale Interleukin‐11 (IL‐11) has emerged as a significant player in tumourigenesis, with implications across various cancer types. However, its specific role in driving tumour progression in lung adenocarcinoma (LUAD) remains elusive.
Cristina Cirauqui +25 more
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Interleukin-11: A pivotal player and potential therapeutic target in prostate cancer [PDF]
Current UrologyInterleukin-11 (IL-11), a pleiotropic cytokine belonging to the interleukin-6 (IL-6) family, is implicated in the initiation and progression of various malignancies.
Jinghua Zhong +5 more
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An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma [PDF]
Bioengineering & Translational Medicine, 2023 The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention.
Brianna J. McIntosh +6 more
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Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis [PDF]
Nature Communications, 2022 Here, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. Interleukin-11 secreted by the bone acts as a hormone to regulate fat metabolism, in addition to having an autocrine-paracrine effect
Bingzi Dong +17 more
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Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy [PDF]
Human Vaccines & Immunotherapeutics, 2020 The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor.
Anissa A. Widjaja +2 more
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The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans [PDF]
Scientific Reports, 2023 Craniosynostosis is characterized by the premature fusion and ossification of one or more of the sutures of the calvaria, often resulting in abnormal features of the face and the skull.
Ilyas Ahmad +15 more
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