Identification of interleukin-11 as a comorbid risk factor for prostate cancer and Alzheimer’s disease using integrated bioinformatics and machine learning [PDF]
Frontiers in ImmunologyBackgroundProstate cancer (PCa) and Alzheimer’s disease (AD) are age-related disorders with a complex epidemiological association and limited therapeutic options.
Mengxue Wang +18 more
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Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer [PDF]
Cells, 2022 Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer and is a fast progressive disease when left untreated. Identification of potential biomarkers in NSCLC is an ongoing area of research that aims to detect, diagnose, and prognosticate ...
Jason Hongting Leung +2 more
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Interleukin-11 disrupts alveolar epithelial progenitor function [PDF]
ERJ Open Research, 2023 Background Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates their excessive collagen deposition in the lung.
Rosa K. Kortekaas +7 more
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Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice [PDF]
iScience, 2023 Summary: Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases.
Takashi Nishina +6 more
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Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases [PDF]
Biomedicines, 2021 Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher ...
Paola Maroni +3 more
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion [PDF]
Clinical and Translational MedicineRationale Interleukin‐11 (IL‐11) has emerged as a significant player in tumourigenesis, with implications across various cancer types. However, its specific role in driving tumour progression in lung adenocarcinoma (LUAD) remains elusive.
Cristina Cirauqui +25 more
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Interleukin-11: A pivotal player and potential therapeutic target in prostate cancer [PDF]
Current UrologyInterleukin-11 (IL-11), a pleiotropic cytokine belonging to the interleukin-6 (IL-6) family, is implicated in the initiation and progression of various malignancies.
Jinghua Zhong +5 more
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An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma [PDF]
Bioengineering & Translational Medicine, 2023 The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention.
Brianna J. McIntosh +6 more
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Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia [PDF]
BMC Oral Health, 2023 Objective This study aimed to investigate the clinical effects of recombinant human interleukin-11 (rhIL-11) gargle on preventing and treating oral mucositis (OM) after chemotherapy for acute leukemia.
Yilin Zhang +9 more
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Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis [PDF]
Nature Communications, 2022 Here, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. Interleukin-11 secreted by the bone acts as a hormone to regulate fat metabolism, in addition to having an autocrine-paracrine effect
Bingzi Dong +17 more
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