Results 21 to 30 of about 603,945 (245)

Restoration of IL-11 and IL-15 cytokine production post calcium modulators and ROS treatment can assist viral clearance both in vitro and in vivo [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Hepatitis B virus (HBV) infection alters the cytokines production to establish persistent infection. A reversion of cytokines back to their normal state can be a promising therapeutic approach to establish an optimal host immune response ...
Kehkshan Jabeen, Aneela Javed, Asim Waris, Shaheen Shahzad   +3 more
doaj   +1 more source

Effects of IL-11/IL-11 Receptor Alpha on Proliferation and Steroidogenesis in Ovarian Granulosa Cells of Dairy Cows

Cells, 2023
Granulosa cells (GCs) are essential for follicular growth, oocyte maturation, and steroidogenesis in the ovaries. Interleukin (IL)-11 is known to play a crucial role in the decidualization of the uterus, however, the expression of the IL-11 system (IL-11,
Hanxiao Wu, Peihao Sun, Ce Lv, Xinzhe Zhao, Mingxiao Liu, Qunli Zhou, Jiaomei Tang, Liguo Yang, Aixin Liang   +8 more
doaj   +1 more source

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

Frontiers in Molecular Biosciences, 2021
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated ...
Anissa A. Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K. Singh, Jessie Tan, Joyce Goh Wei Ting, David Lamb, Shamini G. Shekeran, Benjamin L. George, Sebastian Schafer, David Carling, Eleonora Adami, Stuart A. Cook, Stuart A. Cook, Stuart A. Cook   +14 more
doaj   +1 more source

The biology of interleukin 11 [PDF]

STEM CELLS, 1996
Interleukin 11 (IL-11) is a multifunctional cytokine which may play a role in regulating the growth and development of cells in both the hematopoietic and lymphoid systems. IL-11 activity was originally detected in the conditioned medium of a primate bone marrow stromal cell line, and the human cDNA was cloned from a human fetal lung fibroblast cell ...
S, Neben, K, Turner
openaire   +2 more sources

Interleukin-11

The International Journal of Biochemistry & Cell Biology, 1997
Interleukin-11 (IL-11) is an IL-6-type cytokine that is produced by a variety of stromal cells including fibroblasts, epithelial cells and osteoblasts. It binds to a multimeric receptor complex which contains an IL-11-specific alpha subunit and a promiscuous 130 kDa beta subunit (gp130). IL-11 stimulates multiple aspects of hematopoiesis and hepatocyte
S X, Leng, J A, Elias
openaire   +3 more sources

Increased Interleukin-11 and Stress-Related Gene Expression in Human Endothelial and Bronchial Epithelial Cells Exposed to Silver Nanoparticles

Biomolecules, 2021
This article aimed to identify and distinguish the various responses to silver nanoparticles (NPs) of endothelial and epithelial cells. We also assessed the significantly increased gene expression levels, as shown by microarray analysis. We evaluated the
Jiyoung Jang, Sun Park, In-Hong Choi
doaj   +1 more source

Periodontal manifestations as related to the cytokines in the gingival crevicular fluid

Indian Journal of Dental Sciences, 2021
Backround: Periodontal diseases are classified into different categories based on the clinical symptoms and related to these there can be changes in the cytokine levels in the connective tissue and elaboration of these in the gingival crevicular fluid ...
Nymphea Pandit, Neeta Bhavsar
doaj   +1 more source

Repairing effects of interleukin 11 (IL-11) towards high dose methotrexate-induced rat small intestinal mucositis and its impacts on T-lymphoblastic leukemia cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): To investigate the efficacy of interleukin 11 (IL-11) towards the high dose methotrexate (HDMTX)-concurrent rat small intestinal mucositis and its impacts on the proliferation of the human T-lymphoblastic leukemia (CEM) cell line. Materials
Yueqin Han, Yanping Zhu, Jinshen Wang, Yanqin Han, Daogang Qin, Qiaozhi Yang, Xiaojing Sun, Lijun Chen   +7 more
doaj   +3 more sources

Interleukin-11 - its role in the vicious cycle of inflammation, periodontitis and diabetes: A clinicobiochemical cross-sectional study

Journal of Indian Society of Periodontology, 2015
Context: Interleukin-11 (IL-11) is a multifunctional cytokine with a probable regulatory role in the inflamed periodontal tissue. It has also been shown to inhibit the production of potent proinflammatory cytokines like tumor necrosis factor-alpha, IL-6 ...
Rohit Prasad, Aganashini Suchetha, Puzhankara Lakshmi, Mundinamane Basawalingappa Darshan, Sokke Mallikarjuna Apoorva, Gulabdas Bharwani Ashit   +5 more
doaj   +1 more source

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

Frontiers in Immunology, 2020
Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)
Riley D. Metcalfe, Tracy L. Putoczki, Tracy L. Putoczki, Michael D. W. Griffin   +3 more
doaj   +1 more source