Interleukin-11 disrupts alveolar epithelial progenitor function [PDF]
ERJ Open Research, 2023 Background Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates their excessive collagen deposition in the lung.
Rosa K. Kortekaas +7 more
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Effect of α-mangostin on interleukin-11 and runt-related transcription factor-2 gene expression on cell line osteoblast cultures induced with lipopolysaccharide [PDF]
Contemporary Clinical Dentistry, 2023 Background: Loss of permanent teeth after tooth extraction without replacement of missing teeth can result in impaired masticatory, esthetic, phonetic functions, and impaired balance of the masticatory organ in the mouth. Therefore, a method is needed to
Ivan Tantra +6 more
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Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice [PDF]
iScience, 2023 Summary: Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases.
Takashi Nishina +6 more
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Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases [PDF]
Biomedicines, 2021 Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher ...
Paola Maroni +3 more
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion [PDF]
Clinical and Translational MedicineRationale Interleukin‐11 (IL‐11) has emerged as a significant player in tumourigenesis, with implications across various cancer types. However, its specific role in driving tumour progression in lung adenocarcinoma (LUAD) remains elusive.
Cristina Cirauqui +25 more
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Interleukin-11/IL-11 Receptor Promotes Glioblastoma Cell Proliferation, Epithelial–Mesenchymal Transition, and Invasion [PDF]
Brain SciencesGlioblastoma is highly proliferative and invasive. However, the regulatory cytokine networks that promote glioblastoma cell proliferation and invasion into other areas of the brain are not fully defined.
Sarah F. Stuart +9 more
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Interleukin-11: A pivotal player and potential therapeutic target in prostate cancer [PDF]
Current UrologyInterleukin-11 (IL-11), a pleiotropic cytokine belonging to the interleukin-6 (IL-6) family, is implicated in the initiation and progression of various malignancies.
Jinghua Zhong +5 more
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An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma [PDF]
Bioengineering & Translational Medicine, 2023 The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention.
Brianna J. McIntosh +6 more
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Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy [PDF]
Human Vaccines & Immunotherapeutics, 2020 The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor.
Anissa A. Widjaja +2 more
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Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia [PDF]
BMC Oral Health, 2023 Objective This study aimed to investigate the clinical effects of recombinant human interleukin-11 (rhIL-11) gargle on preventing and treating oral mucositis (OM) after chemotherapy for acute leukemia.
Yilin Zhang +9 more
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