A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling [PDF]
iScience, 2021 Summary: Blocking the activity of cytokines is an efficient strategy to combat inflammatory diseases. Interleukin-6 (IL-6) fulfills its pro-inflammatory properties via its soluble receptor (IL-6 trans-signaling).
Juliane Lokau +3 more
doaj +2 more sources
Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina [PDF]
Journal of NeuroinflammationBackground The IL-6 cytokine family, with its crucial and pleiotropic intracellular signaling pathway STAT3, is a promising target for treating vasoproliferative retinal diseases.
Paula Liang +8 more
doaj +2 more sources
Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy [PDF]
ResearchSepsis-associated encephalopathy (SAE) is a severe and frequent septic complication, characterized by neuronal damage as key pathological features. The astrocyte–microglia crosstalk in the central nervous system (CNS) plays important roles in various ...
Dandan Zhu +6 more
doaj +2 more sources
Understanding interleukin 11 as a disease gene and therapeutic target. [PDF]
Biochem J, 2023 Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show instead that IL11 is redundant for haematopoiesis and toxic.
Cook SA.
europepmc +2 more sources
Triple‐Negative Breast Cancer Cells Resist Natural Killer Cell‐Mediated Killing Through Interleukin‐11 Trans‐Signaling [PDF]
Advanced ScienceNatural killer (NK) cell‐based therapies show great promise for treating triple‐negative breast cancer (TNBC). However, in the tumor microenvironment, some TNBC cells develop resistance to NK cell‐mediated killing and contribute to NK cell exhaustion. In
Hongmei Yang +5 more
doaj +2 more sources
Expression, Purification, and Characterization of Interleukin-11 Orthologues [PDF]
Molecules, 2016 Interleukin-11 (IL-11) is a multifunctional cytokine implicated in several normal and pathological processes. The decoding of IL-11 function and development of IL-11-targeted drugs dictate the use of laboratory animals and need of the better ...
Andrei S. Sokolov +11 more
doaj +4 more sources
Mediators of Inflammation, 2016 The cytokines interleukin-11 (IL-11) and IL-6 are important proteins with well-defined pro- and anti-inflammatory functions. They activate intracellular signaling cascades through a homodimer of the ubiquitously expressed signal-transducing β-receptor ...
Juliane Lokau +2 more
doaj +2 more sources
The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells [PDF]
Contemporary OncologyJosephine Runge +2 more
doaj +2 more sources
Cell Reports, 2018 Summary: Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis.
Maria Agthe +14 more
doaj +2 more sources
Interleukin-11 in Pathologies of the Nervous System. [PDF]
Mol Biol, 2023 The study of the role of cytokines in various pathological conditions of the body is one of the topical areas of modern biomedicine. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been an increased interest in the cytokine in recent years.
Airapetov MI +5 more
europepmc +4 more sources