Results 21 to 30 of about 632,731 (200)

Restoration of IL-11 and IL-15 cytokine production post calcium modulators and ROS treatment can assist viral clearance both in vitro and in vivo [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Hepatitis B virus (HBV) infection alters the cytokines production to establish persistent infection. A reversion of cytokines back to their normal state can be a promising therapeutic approach to establish an optimal host immune response ...
Kehkshan Jabeen, Aneela Javed, Asim Waris, Shaheen Shahzad   +3 more
doaj   +1 more source

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

Frontiers in Immunology, 2020
Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)
Riley D. Metcalfe, Tracy L. Putoczki, Tracy L. Putoczki, Michael D. W. Griffin   +3 more
doaj   +1 more source

Repairing effects of interleukin 11 (IL-11) towards high dose methotrexate-induced rat small intestinal mucositis and its impacts on T-lymphoblastic leukemia cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): To investigate the efficacy of interleukin 11 (IL-11) towards the high dose methotrexate (HDMTX)-concurrent rat small intestinal mucositis and its impacts on the proliferation of the human T-lymphoblastic leukemia (CEM) cell line. Materials
Yueqin Han, Yanping Zhu, Jinshen Wang, Yanqin Han, Daogang Qin, Qiaozhi Yang, Xiaojing Sun, Lijun Chen   +7 more
doaj   +3 more sources

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy

Human Vaccines & Immunotherapeutics, 2020
The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor.
Anissa A. Widjaja, Sonia P. Chothani, Stuart A. Cook   +2 more
doaj   +1 more source

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

Frontiers in Molecular Biosciences, 2021
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated ...
Anissa A. Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K. Singh, Jessie Tan, Joyce Goh Wei Ting, David Lamb, Shamini G. Shekeran, Benjamin L. George, Sebastian Schafer, David Carling, Eleonora Adami, Stuart A. Cook, Stuart A. Cook, Stuart A. Cook   +14 more
doaj   +1 more source

Increased Interleukin-11 and Stress-Related Gene Expression in Human Endothelial and Bronchial Epithelial Cells Exposed to Silver Nanoparticles

Biomolecules, 2021
This article aimed to identify and distinguish the various responses to silver nanoparticles (NPs) of endothelial and epithelial cells. We also assessed the significantly increased gene expression levels, as shown by microarray analysis. We evaluated the
Jiyoung Jang, Sun Park, In-Hong Choi
doaj   +1 more source

Pilot study on molecular quantitation and sequencing of endometrial cytokines gene expression and their effect on the outcome of in vitro fertilization (IVF) cycle

Journal of Advanced Research, 2014
Human trophoblast invasion and differentiation are essential for successful pregnancy outcome. The molecular mechanisms, however, are poorly understood. Interleukin (IL)-11, a cytokine, regulates endometrial epithelial cell adhesion.
D. Sabry, O. Nouh, S. Marzouk, A. Hassouna   +3 more
doaj   +1 more source

Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis

International Brazilian Journal of Urology, 2007
OBJECTIVE: To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC) MATERIALS AND METHODS: Male Swiss mice (20-30g) were pretreated with rhIL-11 (25-625 mg ...
Jose M. Mota, Gerly A. Brito, Raphael T. Loiola, Fernando Q. Cunha, Ronaldo de A. Ribeiro   +4 more
doaj   +1 more source

A designer hyper interleukin 11 (H11) is a biologically active cytokine

BMC Biotechnology, 2012
Background Interleukin 11 (IL-11) is a pleiotropic cytokine with anti-apoptotic, anti-inflammatory and hematopoietic potential. The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β
Dams-Kozlowska Hanna, Gryska Katarzyna, Kwiatkowska-Borowczyk Eliza, Izycki Dariusz, Rose-John Stefan, Mackiewicz Andrzej   +5 more
doaj   +1 more source

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

EMBO Molecular Medicine, 2019
Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression.
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand   +17 more
doaj   +1 more source