Results 41 to 50 of about 4,886,092 (271)

Restoration of IL-11 and IL-15 cytokine production post calcium modulators and ROS treatment can assist viral clearance both in vitro and in vivo [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Hepatitis B virus (HBV) infection alters the cytokines production to establish persistent infection. A reversion of cytokines back to their normal state can be a promising therapeutic approach to establish an optimal host immune response ...
Kehkshan Jabeen, Aneela Javed, Asim Waris, Shaheen Shahzad   +3 more
doaj   +1 more source

Repairing effects of interleukin 11 (IL-11) towards high dose methotrexate-induced rat small intestinal mucositis and its impacts on T-lymphoblastic leukemia cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): To investigate the efficacy of interleukin 11 (IL-11) towards the high dose methotrexate (HDMTX)-concurrent rat small intestinal mucositis and its impacts on the proliferation of the human T-lymphoblastic leukemia (CEM) cell line. Materials
Yueqin Han, Yanping Zhu, Jinshen Wang, Yanqin Han, Daogang Qin, Qiaozhi Yang, Xiaojing Sun, Lijun Chen   +7 more
doaj   +3 more sources

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

Frontiers in Molecular Biosciences, 2021
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated ...
Anissa A. Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K. Singh, Jessie Tan, Joyce Goh Wei Ting, David Lamb, Shamini G. Shekeran, Benjamin L. George, Sebastian Schafer, David Carling, Eleonora Adami, Stuart A. Cook, Stuart A. Cook, Stuart A. Cook   +14 more
doaj   +1 more source

Increased Interleukin-11 and Stress-Related Gene Expression in Human Endothelial and Bronchial Epithelial Cells Exposed to Silver Nanoparticles

Biomolecules, 2021
This article aimed to identify and distinguish the various responses to silver nanoparticles (NPs) of endothelial and epithelial cells. We also assessed the significantly increased gene expression levels, as shown by microarray analysis. We evaluated the
Jiyoung Jang, Sun Park, In-Hong Choi
doaj   +1 more source

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Science Translational Medicine, 2019
Interleukin-11 is important for lung fibroblast activation in idiopathic pulmonary fibrosis, and its signaling represents a therapeutic target. Targeting IL-11 in lung fibrosis In idiopathic pulmonary fibrosis (IPF), chronic activation of invasive ...
B. Ng, Jinrui Dong, Giuseppe D’Agostino, S. Viswanathan, A. Widjaja, Wei-Wen Lim, Nicole S. J. Ko, Jessie Tan, S. Chothani, Benjamin Huang, Chen Xie, C. Pua, A. Chacko, Nuno Guimarães-Camboa, S. Evans, A. Byrne, T. Maher, Jiurong Liang, D. Jiang, P. Noble, S. Schafer, S. Cook   +21 more
semanticscholar   +1 more source

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models

Scientific Reports, 2020
Transforming growth factor beta-1 (TGFβ1) is a major driver of vascular smooth muscle cell (VSMC) phenotypic switching, an important pathobiology in arterial disease.
Wei-Wen Lim, B. Corden, B. Ng, K. Vanezis, Giuseppe D’Agostino, A. Widjaja, Weihua Song, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G. Z. Tee, Jinrui Dong, Nicole S. J. Ko, Mao Wang, C. Pua, Muhammad H. Jamal, Bee Y. Soh, S. Viswanathan, S. Schafer, S. Cook   +19 more
semanticscholar   +1 more source

Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation.

Annual Review of Medicine, 2020
Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease, kidney disease, drug-induced liver injury, and nonalcoholic ...
S. Cook, S. Schafer
semanticscholar   +1 more source

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis.

Gastroenterology, 2019
BACKGROUND & AIMS We studied the role of interleukin 11 (IL11) signaling in the pathogenesis of nonalcoholic steatohepatitis using hepatic stellate cells (HSCs), hepatocytes, and mouse models of non-alcoholic steatohepatitis (NASH).
A. Widjaja, B. Singh, E. Adami, S. Viswanathan, Jinrui Dong, Giuseppe D’Agostino, B. Ng, Wei-Wen Lim, Jessie Tan, B. Paleja, Madhulika Tripathi, S. Lim, Shamini G Shekeran, S. Chothani, Anne Rabes, M. Sombetzki, E. Bruinstroop, Li Min, R. Sinha, S. Albani, P. Yen, S. Schafer, S. Cook   +22 more
semanticscholar   +1 more source

Pilot study on molecular quantitation and sequencing of endometrial cytokines gene expression and their effect on the outcome of in vitro fertilization (IVF) cycle

Journal of Advanced Research, 2014
Human trophoblast invasion and differentiation are essential for successful pregnancy outcome. The molecular mechanisms, however, are poorly understood. Interleukin (IL)-11, a cytokine, regulates endometrial epithelial cell adhesion.
D. Sabry, O. Nouh, S. Marzouk, A. Hassouna   +3 more
doaj   +1 more source

Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
OBJECTIVE Inflammation and immune responses are crucial factors associated with the onset and progression of stroke. Interleukin-11 (IL-11) is a hematopoietic IL-6 family cytokine that functions as an anti-inflammatory agent against various inflammatory ...
Bei Zhang, Haixiao Zhang, Shao-Ting Shi, Yukun Bai, X. Zhe, Shijun Zhang, Ya-Jun Li   +6 more
semanticscholar   +1 more source