Results 51 to 60 of about 4,886,092 (271)

Interleukin‐11 regulates the fate of adipose‐derived mesenchymal stem cells via STAT3 signalling pathways

Cell Proliferation, 2020
Adipose‐derived mesenchymal stem cells (ADSCs) offer great promise as cell therapy for ischaemic diseases. Due to their poor survival in the ischaemic environment, the therapeutic efficacy of ADSCs is still relatively low. Interleukin‐11 (IL‐11) has been
Wenlong Yang, Shuning Zhang, Tiantong Ou, Hao Jiang, Daile Jia, Zhiyong Qi, Y. Zou, J. Qian, A. Sun, J. Ge   +9 more
semanticscholar   +1 more source

Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis

International Brazilian Journal of Urology, 2007
OBJECTIVE: To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC) MATERIALS AND METHODS: Male Swiss mice (20-30g) were pretreated with rhIL-11 (25-625 mg ...
Jose M. Mota, Gerly A. Brito, Raphael T. Loiola, Fernando Q. Cunha, Ronaldo de A. Ribeiro   +4 more
doaj   +1 more source

Mediation of interleukin-11-dependent biological responses by a soluble form of the interleukin-11 receptor [PDF]

Biochemical Journal, 1996
Interleukin-11 (IL-11) is a polyfunctional cytokine whose biological actions require a specific IL-11 receptor (IL-11R) and the transmembrane transducer gp130. Here we report the production of a soluble form of the murine IL-11R and demonstrate that it interacts with IL-11 ligand with high affinity.
Karow, J, Hudson, K R, Hall, M A, Vernallis, A B, Taylor, J A, Gossler, A, Heath, J K   +6 more
openaire   +2 more sources

A designer hyper interleukin 11 (H11) is a biologically active cytokine

BMC Biotechnology, 2012
Background Interleukin 11 (IL-11) is a pleiotropic cytokine with anti-apoptotic, anti-inflammatory and hematopoietic potential. The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β
Dams-Kozlowska Hanna, Gryska Katarzyna, Kwiatkowska-Borowczyk Eliza, Izycki Dariusz, Rose-John Stefan, Mackiewicz Andrzej   +5 more
doaj   +1 more source

Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis [PDF]

Gut, 1999
BACKGROUND Proinflammatory and anti-inflammatory cytokines are involved in the pathogenesis of acute pancreatitis. AIMS To measure the serial serum levels of interleukin 10 and interleukin 11 in patients with acute pancreatitis and ...
C C, Chen, S S, Wang, R H, Lu, F Y, Chang, S D, Lee   +4 more
openaire   +2 more sources

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

EMBO Molecular Medicine, 2019
Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression.
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand   +17 more
doaj   +1 more source

The Role of Recombinant Interleukin 11 in Megakaryocytopoiesis [PDF]

Stem Cells, 1996
Recombinant human interleukin 11 (rHuIL-11) is a multifunctional cytokine with activities on a broad range of hematopoietic cells including primitive stem cells and mature progenitor cells. Analysis of rHuIL-11 in vitro has revealed that its hematopoietic activities are predominantly a result of synergistic interactions with other early-acting factors ...
K J, Turner, S, Neben, N, Weich, R G, Schaub, S J, Goldman   +4 more
openaire   +2 more sources

microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11

Molecular Cancer, 2018
Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event in the metastases of breast cancer to bone. microRNA-124 (
Weiluo Cai, Wending Huang, Bo Li, Tianrui Chen, Zhen-Xi Li, Chenglong Zhao, Hengyu Li, Yan-mei Wu, Wang-Jun Yan, Jianru Xiao   +9 more
semanticscholar   +1 more source

A fusion protein of interleukin‐11 and soluble interleukin‐11 receptor acts as a superagonist on cells expressing gp130 [PDF]

FEBS Letters, 1999
Interleukin‐11 is a hematopoietic cytokine that signals via the signal transducer gp130. Although gp130 is ubiquitously expressed, interleukine‐11 responsiveness is restricted to cells that express the interleukine‐11 receptor α‐subunit. The interleukine‐11 receptor α‐subunit can be functionally replaced by its soluble form indicating that the ...
S, Pflanz, I, Tacken, J, Grötzinger, Y, Jacques, S, Minvielle, H, Dahmen, P C, Heinrich, G, Müller-Newen   +7 more
openaire   +3 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source