Results 11 to 20 of about 4,886,092 (271)
Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis [PDF]
Nature Communications, 2022 Here, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. Interleukin-11 secreted by the bone acts as a hormone to regulate fat metabolism, in addition to having an autocrine-paracrine effect
Bingzi Dong +17 more
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Frontiers in Immunology, 2020 Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)
Riley D. Metcalfe +3 more
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The role of proteolysis in interleukin-11 signaling
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022 Although interleukin-11 (IL-11) was discovered more than 30 years ago, it remains an understudied member of the IL-6 family of cytokines. While it was originally discovered as a secreted factor that could foster megakaryocyte maturation and was therefore used as a recombinant protein to increase platelet production in patients with thrombocytopenia ...
Juliane, Lokau +3 more
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The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans [PDF]
Scientific Reports, 2023 Craniosynostosis is characterized by the premature fusion and ossification of one or more of the sutures of the calvaria, often resulting in abnormal features of the face and the skull.
Ilyas Ahmad +15 more
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Proteolytic control of Interleukin-11 and Interleukin-6 biology
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017 Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important homeostatic functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-11R and IL-6R, respectively). Formation of IL-11/IL-11R and IL-6/IL-6R complexes triggers the recruitment of a homodimer of the ubiquitously expressed signal ...
Juliane Lokau +3 more
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PLoS ONE, 2020 Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor.
Wei-Wen Lim +10 more
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Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer [PDF]
Cells, 2022 Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer and is a fast progressive disease when left untreated. Identification of potential biomarkers in NSCLC is an ongoing area of research that aims to detect, diagnose, and prognosticate ...
Jason Hongting Leung +2 more
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Roles of interleukin-11 during acute bacterial pneumonia.
PLoS ONE, 2019 Interleukin-11 (IL-11) is an interleukin-6 (IL-6) family cytokine shown to play a protective role in acute inflammatory settings including systemic infection.
Katrina E Traber +6 more
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Efficacy of human interleukin-11 analogs for treating dengue fever-associated thrombocytopenia: a prospective cohort [PDF]
European Journal of Medical ResearchAim Dengue fever (DF), carried by Aedes mosquitoes, affects millions worldwide. Platelet-inducing human IL-11 analogues may be effective in treating DF-associated thrombocytopenia. Methodology A prospective study was done at Dr.
Sidra Khan +9 more
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A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis [PDF]
BMC Oral Health, 2022 Background This prospective interventional study aimed to evaluate and analyse the efficacy of rhIL-11 mouthwash compared to Kangfuxin fluid in treatment and blank control in prevention of oral mucositis (OM) in patients receiving chemotherapy. Materials
Hangping Wei, Juan Wei, Xiaofang Dong
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