The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans [PDF]
Scientific Reports, 2023 Craniosynostosis is characterized by the premature fusion and ossification of one or more of the sutures of the calvaria, often resulting in abnormal features of the face and the skull.
Ilyas Ahmad +15 more
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Efficacy of human interleukin-11 analogs for treating dengue fever-associated thrombocytopenia: a prospective cohort [PDF]
European Journal of Medical ResearchAim Dengue fever (DF), carried by Aedes mosquitoes, affects millions worldwide. Platelet-inducing human IL-11 analogues may be effective in treating DF-associated thrombocytopenia. Methodology A prospective study was done at Dr.
Sidra Khan +9 more
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Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer [PDF]
Cells, 2022 Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer and is a fast progressive disease when left untreated. Identification of potential biomarkers in NSCLC is an ongoing area of research that aims to detect, diagnose, and prognosticate ...
Jason Hongting Leung +2 more
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A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis [PDF]
BMC Oral Health, 2022 Background This prospective interventional study aimed to evaluate and analyse the efficacy of rhIL-11 mouthwash compared to Kangfuxin fluid in treatment and blank control in prevention of oral mucositis (OM) in patients receiving chemotherapy. Materials
Hangping Wei, Juan Wei, Xiaofang Dong
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Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina [PDF]
Journal of NeuroinflammationBackground The IL-6 cytokine family, with its crucial and pleiotropic intracellular signaling pathway STAT3, is a promising target for treating vasoproliferative retinal diseases.
Paula Liang +8 more
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy [PDF]
ResearchSepsis-associated encephalopathy (SAE) is a severe and frequent septic complication, characterized by neuronal damage as key pathological features. The astrocyte–microglia crosstalk in the central nervous system (CNS) plays important roles in various ...
Dandan Zhu +6 more
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The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells [PDF]
Contemporary OncologyJosephine Runge +2 more
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Cells, 2023 Granulosa cells (GCs) are essential for follicular growth, oocyte maturation, and steroidogenesis in the ovaries. Interleukin (IL)-11 is known to play a crucial role in the decidualization of the uterus, however, the expression of the IL-11 system (IL-11,
Hanxiao Wu +8 more
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IL11 activates the placental inflammasome to drive preeclampsia
Frontiers in Immunology, 2023 IntroductionPreeclampsia is a life-threatening disorder of pregnancy unique to humans. Interleukin (IL)11 is elevated in serum from pregnancies that subsequently develop early-onset preeclampsia and pharmacological elevation of IL11 in pregnant mice ...
Ellen Menkhorst +24 more
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Periodontal manifestations as related to the cytokines in the gingival crevicular fluid
Indian Journal of Dental Sciences, 2021 Backround: Periodontal diseases are classified into different categories based on the clinical symptoms and related to these there can be changes in the cytokine levels in the connective tissue and elaboration of these in the gingival crevicular fluid ...
Nymphea Pandit, Neeta Bhavsar
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