Results 31 to 40 of about 603,945 (245)

Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis

International Brazilian Journal of Urology, 2007
OBJECTIVE: To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC) MATERIALS AND METHODS: Male Swiss mice (20-30g) were pretreated with rhIL-11 (25-625 mg ...
Jose M. Mota, Gerly A. Brito, Raphael T. Loiola, Fernando Q. Cunha, Ronaldo de A. Ribeiro   +4 more
doaj   +1 more source

Mediation of interleukin-11-dependent biological responses by a soluble form of the interleukin-11 receptor [PDF]

Biochemical Journal, 1996
Interleukin-11 (IL-11) is a polyfunctional cytokine whose biological actions require a specific IL-11 receptor (IL-11R) and the transmembrane transducer gp130. Here we report the production of a soluble form of the murine IL-11R and demonstrate that it interacts with IL-11 ligand with high affinity.
Karow, J, Hudson, K R, Hall, M A, Vernallis, A B, Taylor, J A, Gossler, A, Heath, J K   +6 more
openaire   +2 more sources

The Role of Recombinant Interleukin 11 in Megakaryocytopoiesis [PDF]

Stem Cells, 1996
Recombinant human interleukin 11 (rHuIL-11) is a multifunctional cytokine with activities on a broad range of hematopoietic cells including primitive stem cells and mature progenitor cells. Analysis of rHuIL-11 in vitro has revealed that its hematopoietic activities are predominantly a result of synergistic interactions with other early-acting factors ...
K J, Turner, S, Neben, N, Weich, R G, Schaub, S J, Goldman   +4 more
openaire   +2 more sources

IL11 activates the placental inflammasome to drive preeclampsia

Frontiers in Immunology, 2023
IntroductionPreeclampsia is a life-threatening disorder of pregnancy unique to humans. Interleukin (IL)11 is elevated in serum from pregnancies that subsequently develop early-onset preeclampsia and pharmacological elevation of IL11 in pregnant mice ...
Ellen Menkhorst, Ellen Menkhorst, Ellen Menkhorst, Leilani L. Santos, Leilani L. Santos, Wei Zhou, Wei Zhou, Guannan Yang, Guannan Yang, Guannan Yang, Amy L. Winship, Amy L. Winship, Katarzyna E. Rainczuk, Philana Nguyen, Philana Nguyen, Jian-Guo Zhang, Jian-Guo Zhang, Paddy Moore, Michelle Williams, Kim-Anh Lê Cao, Ashley Mansell, Evdokia Dimitriadis, Evdokia Dimitriadis, Evdokia Dimitriadis, Evdokia Dimitriadis   +24 more
doaj   +1 more source

A fusion protein of interleukin‐11 and soluble interleukin‐11 receptor acts as a superagonist on cells expressing gp130 [PDF]

FEBS Letters, 1999
Interleukin‐11 is a hematopoietic cytokine that signals via the signal transducer gp130. Although gp130 is ubiquitously expressed, interleukine‐11 responsiveness is restricted to cells that express the interleukine‐11 receptor α‐subunit. The interleukine‐11 receptor α‐subunit can be functionally replaced by its soluble form indicating that the ...
S, Pflanz, I, Tacken, J, Grötzinger, Y, Jacques, S, Minvielle, H, Dahmen, P C, Heinrich, G, Müller-Newen   +7 more
openaire   +3 more sources

Evaluation of anti-inflammatory effect of chorion membrane in periodontal pocket therapy: A clinical and biochemical study

Journal of Indian Society of Periodontology, 2018
Background: The aim of the study was to evaluate the anti-inflammatory effect of chorion as a barrier membrane in periodontal pocket therapy by assessing interleukin-11 (IL-11) level in gingival crevicular fluid (GCF).
Shaila Kothiwale, Jyoti Ajbani
doaj   +1 more source

Circulating Interleukins as Biomarkers in Non-Small Cell Lung Cancer Patients: A Pilot Study Compared to Normal Individuals

Diseases
Identifying biomarkers in non-small cell lung cancer (NSCLC) can improve diagnosis and patient stratification. We evaluated plasmas and sera for interleukins (IL)-11, IL-6, IL-8, IL-17A, and IL-33 as biomarkers in primary NSCLC patients undergoing ...
Wei-Wen Lim, Jason H. Leung, Chen Xie, Angelina W. T. Cheng, Liping Su, Luh-Nah Lum, Aishah Toh, Siew-Ching Kong, Angela M. Takano, Derek J. Hausenloy, Yang C. Chua   +10 more
doaj   +1 more source

Pilot study on molecular quantitation and sequencing of endometrial cytokines gene expression and their effect on the outcome of in vitro fertilization (IVF) cycle

Journal of Advanced Research, 2014
Human trophoblast invasion and differentiation are essential for successful pregnancy outcome. The molecular mechanisms, however, are poorly understood. Interleukin (IL)-11, a cytokine, regulates endometrial epithelial cell adhesion.
D. Sabry, O. Nouh, S. Marzouk, A. Hassouna   +3 more
doaj   +1 more source

The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review

Journal of Cardiovascular Development and Disease
Fibrosis is one of the main factors that impair the function of many organs. In the heart, fibrosis leads to contractile dysfunction and arrhythmias, which are important in the development of heart failure.
Yarlla Loyane Lira Braga, José Rodrigues do Carmo Neto, Pablo Igor Ribeiro Franco, Fernanda Rodrigues Helmo, Marlene Antônia dos Reis, Flávia Aparecida de Oliveira, Mara Rúbia Nunes Celes, Marcos Vinícius da Silva, Juliana Reis Machado   +8 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source