Expression, Purification, and Characterization of Interleukin-11 Orthologues [PDF]
Molecules, 2016 Interleukin-11 (IL-11) is a multifunctional cytokine implicated in several normal and pathological processes. The decoding of IL-11 function and development of IL-11-targeted drugs dictate the use of laboratory animals and need of the better ...
Andrei S. Sokolov +11 more
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Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia [PDF]
BMC Oral Health, 2023 Objective This study aimed to investigate the clinical effects of recombinant human interleukin-11 (rhIL-11) gargle on preventing and treating oral mucositis (OM) after chemotherapy for acute leukemia.
Yilin Zhang +9 more
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Interleukin-11/IL-11 Receptor Promotes Glioblastoma Cell Proliferation, Epithelial–Mesenchymal Transition, and Invasion [PDF]
Brain SciencesGlioblastoma is highly proliferative and invasive. However, the regulatory cytokine networks that promote glioblastoma cell proliferation and invasion into other areas of the brain are not fully defined.
Sarah F. Stuart +9 more
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Efficacy of human interleukin-11 analogs for treating dengue fever-associated thrombocytopenia: a prospective cohort [PDF]
European Journal of Medical ResearchAim Dengue fever (DF), carried by Aedes mosquitoes, affects millions worldwide. Platelet-inducing human IL-11 analogues may be effective in treating DF-associated thrombocytopenia. Methodology A prospective study was done at Dr.
Sidra Khan +9 more
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A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis [PDF]
BMC Oral Health, 2022 Background This prospective interventional study aimed to evaluate and analyse the efficacy of rhIL-11 mouthwash compared to Kangfuxin fluid in treatment and blank control in prevention of oral mucositis (OM) in patients receiving chemotherapy. Materials
Hangping Wei, Juan Wei, Xiaofang Dong
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A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling [PDF]
iScience, 2021 Summary: Blocking the activity of cytokines is an efficient strategy to combat inflammatory diseases. Interleukin-6 (IL-6) fulfills its pro-inflammatory properties via its soluble receptor (IL-6 trans-signaling).
Juliane Lokau +3 more
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Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina [PDF]
Journal of NeuroinflammationBackground The IL-6 cytokine family, with its crucial and pleiotropic intracellular signaling pathway STAT3, is a promising target for treating vasoproliferative retinal diseases.
Paula Liang +8 more
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy [PDF]
ResearchSepsis-associated encephalopathy (SAE) is a severe and frequent septic complication, characterized by neuronal damage as key pathological features. The astrocyte–microglia crosstalk in the central nervous system (CNS) plays important roles in various ...
Dandan Zhu +6 more
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The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells [PDF]
Contemporary OncologyJosephine Runge +2 more
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Interleukin-11 in Pathologies of the Nervous System. [PDF]
Mol Biol, 2023 The study of the role of cytokines in various pathological conditions of the body is one of the topical areas of modern biomedicine. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been an increased interest in the cytokine in recent years.
Airapetov MI +5 more
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