The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans [PDF]
Scientific Reports, 2023 Craniosynostosis is characterized by the premature fusion and ossification of one or more of the sutures of the calvaria, often resulting in abnormal features of the face and the skull.
Ilyas Ahmad +15 more
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Interleukin-11/IL-11 Receptor Promotes Glioblastoma Cell Proliferation, Epithelial–Mesenchymal Transition, and Invasion [PDF]
Brain SciencesGlioblastoma is highly proliferative and invasive. However, the regulatory cytokine networks that promote glioblastoma cell proliferation and invasion into other areas of the brain are not fully defined.
Sarah F. Stuart +9 more
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Efficacy of human interleukin-11 analogs for treating dengue fever-associated thrombocytopenia: a prospective cohort [PDF]
European Journal of Medical ResearchAim Dengue fever (DF), carried by Aedes mosquitoes, affects millions worldwide. Platelet-inducing human IL-11 analogues may be effective in treating DF-associated thrombocytopenia. Methodology A prospective study was done at Dr.
Sidra Khan +9 more
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Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina [PDF]
Journal of NeuroinflammationBackground The IL-6 cytokine family, with its crucial and pleiotropic intracellular signaling pathway STAT3, is a promising target for treating vasoproliferative retinal diseases.
Paula Liang +8 more
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy [PDF]
ResearchSepsis-associated encephalopathy (SAE) is a severe and frequent septic complication, characterized by neuronal damage as key pathological features. The astrocyte–microglia crosstalk in the central nervous system (CNS) plays important roles in various ...
Dandan Zhu +6 more
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The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells [PDF]
Contemporary OncologyJosephine Runge +2 more
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Restoration of IL-11 and IL-15 cytokine production post calcium modulators and ROS treatment can assist viral clearance both in vitro and in vivo [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Hepatitis B virus (HBV) infection alters the cytokines production to establish persistent infection. A reversion of cytokines back to their normal state can be a promising therapeutic approach to establish an optimal host immune response ...
Kehkshan Jabeen +3 more
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Cells, 2023 Granulosa cells (GCs) are essential for follicular growth, oocyte maturation, and steroidogenesis in the ovaries. Interleukin (IL)-11 is known to play a crucial role in the decidualization of the uterus, however, the expression of the IL-11 system (IL-11,
Hanxiao Wu +8 more
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Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts
Frontiers in Molecular Biosciences, 2021 In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated ...
Anissa A. Widjaja +14 more
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Biomolecules, 2021 This article aimed to identify and distinguish the various responses to silver nanoparticles (NPs) of endothelial and epithelial cells. We also assessed the significantly increased gene expression levels, as shown by microarray analysis. We evaluated the
Jiyoung Jang, Sun Park, In-Hong Choi
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