Results 31 to 40 of about 1,613,518 (229)

Upregulation of IL-11, an IL-6 Family Cytokine, Promotes Tumor Progression and Correlates with Poor Prognosis in Non-Small Cell Lung Cancer

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cytokines are key players in tumorigenesis and are potential targets in cancer treatment. Although IL-6 has attracted considerable attention, interleukin 11 (IL-11), another member of the IL-6 family, has long been overlooked, and little
Meng Zhao, Yahui Liu, Ran Liu, Jin Qi, Yongwang Hou, Jiao Chang, Li Ren   +6 more
doaj   +1 more source

Interleukin-11 disrupts alveolar epithelial progenitor function

ERJ Open Research, 2023
Background Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates their excessive collagen deposition in the lung.
Rosa K. Kortekaas, Kerstin E. Geillinger-Kästle, Theo Borghuis, Kaoutar Belharch, Megan Webster, Wim Timens, Janette K. Burgess, Reinoud Gosens   +7 more
doaj   +1 more source

YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11

Molecular Medicine, 2019
Background Emerging evidence shows that Hippo signal pathways can regulate the progression of various cancer. While the roles of Yes-associated protein (YAP), the key transducer of Hippo signals, in the development of endometrial cancer (EC) are rarely ...
Jing Wang, Tiefang Song, Suiyang Zhou, Xianchao Kong   +3 more
doaj   +1 more source

Clinical value of serum and exhaled breath condensate inflammatory factor IL-11 levels in non-small cell lung cancer: Clinical value of IL-11 in non-small cell lung cancer

The International Journal of Biological Markers, 2021
Objective: Our study aimed to observe and evaluate the clinical value of interleukin (IL)-11 in the serum and exhaled breath condensate of patients with non-small cell lung cancer (NSCLC).
Jinnan Wu, Jinliang Chen, Xuedong Lv, Qichang Yang, Sumei Yao, Dongmei Zhang, Jianrong Chen   +6 more
doaj   +1 more source

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Cell Reports, 2016
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Niloufar Monhasery, Jens Moll, Carly Cuman, Manuel Franke, Larissa Lamertz, Rebecca Nitz, Boris Görg, Dieter Häussinger, Juliane Lokau, Doreen M. Floss, Roland Piekorz, Eva Dimitriadis, Christoph Garbers, Jürgen Scheller   +13 more
doaj   +1 more source

IL-11-An aging-related cytokine with opportunities for regulating hematopoiesis. [PDF]

Hemasphere
Kent DG.
europepmc   +5 more sources

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

Communications Biology, 2023
All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii, Christiane Seibel, Hendrik T. Weitz, Julia Ettich, Anna Rita Minafra, Patrick Petzsch, Alexander Lang, Doreen M. Floss, Kristina Behnke, Karl Köhrer, Jens M. Moll, Jürgen Scheller   +11 more
doaj   +1 more source

Emerging roles for IL-11 in inflammatory diseases

Cytokine, 2022
Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function remains less well-characterized. Here, we summarize current literature surrounding the contribution of IL-
Fung, KY, Louis, C, Metcalfe, RD, Kosasih, CC, Wicks, IP, Griffin, MDW, Putoczki, TL   +6 more
openaire   +3 more sources

Assessment of intralesional cytokine profile of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka

BMC Microbiology, 2019
Background Cytokines play a vital role in the host immune response to infection by initiating the healing process and/or accelerating the progression of the disease in cutaneous leishmaniasis (CL).
Lahiru Sandaruwan Galgamuwa, Buthsiri Sumanasena, Devika Iddawela, Susiji Wickramasinghe, Lalani Yatawara   +4 more
doaj   +1 more source

Zac1 regulates IL-11 expression in osteoarthritis [PDF]

Oncotarget, 2018
Interleukin (IL)-11, a member of the IL-6 family of cytokines, exerts pleiotropic effects under normal and various disease conditions. We assessed IL-11 expression regulation and the IL-11/IL-6 ratio in osteoarthritis (OA) to better guide clinical therapeutic decision-making.
Kuo, Chun-Lin, Liu, Shu-Ting, Chang, Yung-Lung, Wu, Chia-Chun, Huang, Shih-Ming   +4 more
openaire   +2 more sources