Results 41 to 50 of about 7,897,153 (261)
Differential expression of cytokines and receptor expression during anoxic growth
BMC Research Notes, 2018 Objective Cell density in tumor cell three dimensional (3D) cultures affects secretome expression of components. A microenvironment characteristic shared by high-density 3D cell culture and in vivo tumor masses is poor oxygenation, with anoxia being a ...
Balbina J. Plotkin +4 more
doaj +1 more source
Experimental and Molecular Medicine, 2020 To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 and crosstalk between p16INK4a and reactive oxygen ...
Haiyun Chen +13 more
semanticscholar +1 more source
Journal of Advanced Research, 2014 Human trophoblast invasion and differentiation are essential for successful pregnancy outcome. The molecular mechanisms, however, are poorly understood. Interleukin (IL)-11, a cytokine, regulates endometrial epithelial cell adhesion.
D. Sabry +3 more
doaj +1 more source
Interleukin-11 disrupts alveolar epithelial progenitor function
ERJ Open Research, 2023 Background Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates their excessive collagen deposition in the lung.
Rosa K. Kortekaas +7 more
doaj +1 more source
Oncotarget, 2015 The clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) is the first clinically evident phase of the disease. An autoimmune response against myelin proteins is considered the key pathogenic process that initiates MS. Peripherally activated myelin-reactive T cells that transmigrate across the blood brain barrier initiate an ...
Zhang, X, Putoczki, T, Markovic-Plese, S
openaire +3 more sources
The International Journal of Biological Markers, 2021 Objective: Our study aimed to observe and evaluate the clinical value of interleukin (IL)-11 in the serum and exhaled breath condensate of patients with non-small cell lung cancer (NSCLC).
Jinnan Wu +6 more
doaj +1 more source
Communications Biology, 2023 All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii +11 more
doaj +1 more source
IL‐11 in cardiac and renal fibrosis: Late to the party but a central player
British Journal of Pharmacology, 2020 Fibrosis is a pathophysiological hallmark of cardiorenal disease. In the heart, fibrosis leads to contractile dysfunction and arrhythmias; in the kidney, it is the final common pathway for many diseases and predicts end‐stage renal failure. Despite this,
B. Corden +4 more
semanticscholar +1 more source
BMC Microbiology, 2019 Background Cytokines play a vital role in the host immune response to infection by initiating the healing process and/or accelerating the progression of the disease in cutaneous leishmaniasis (CL).
Lahiru Sandaruwan Galgamuwa +4 more
doaj +1 more source
Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor. [PDF]
PLoS ONE, 2014 Intravenous immunoglobulin (IVIg) has been used to treat a variety of autoimmune disorders including multiple sclerosis (MS); however its mechanism of action remains elusive. Recent work has shown that interleukin-11 (IL-11) mRNAs are upregulated by IVIg
Carlyn A Figueiredo +6 more
doaj +1 more source