Results 1 to 10 of about 273,588 (361)

The effect of high-intensity interval training on IL-22 and STAT3 gene expression of liver tissue in steatosis animal model [PDF]

Journal of Exercise & Organ Cross Talk, 2023
Inflammation is a major component of almost all acute and chronic liver disorders, including non-alcoholic fatty liver disease. This study aimed to investigate the effect of high-intensity interval training on IL-22 and STAT3 gene expression of liver ...
Vahideh Ebrahimi Gharab, Mozhgan Ahmadi, Tahere Jahandar Lashaki, Hamidreza Choobdari   +3 more
doaj   +1 more source

Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review

Journal of Inflammation Research, 2022
Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a common signaling pathway used to transduce signals from the extracellular to the intracellular (nucleus) upon the binding of cytokines and growth factors to the ...
Teklie Mengie Ayele, Zelalem Tilahun Muche, Awgichew Behaile Teklemariam, Achenef Bogale Kassie, Endeshaw Chekol Abebe   +4 more
semanticscholar   +1 more source

Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway

Frontiers in Pharmacology, 2021
Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death. Most (75–85%) primary liver cancers occurring worldwide are hepatocellular carcinoma (HCC).
Xue Hu, Fangzhou Jiao, Lan Zhang, Yingan Jiang   +3 more
doaj   +1 more source

Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice

Frontiers in Nutrition, 2021
It is known that lipopolysaccharide (LPS) triggers inflammatory response after intracerebroventricular (ICV) injection and elevates the expression of hepcidin through the interleukin 6/janus kinase 2/transducer and activator of the transcription 3 (IL-6 ...
Fali Zhang, Peng Zhao, Zhongming Qian, Zhongming Qian, Mingkang Zhong   +4 more
doaj   +1 more source

Targeting STAT3 in Cancer Immunotherapy

Molecular Cancer, 2020
As a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune response.
Sailan Zou, Qiyu Tong, Bowen Liu, Wei Huang, Yan Tian, Xianghui Fu   +5 more
semanticscholar   +1 more source

Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation

Theranostics, 2022
Rationale: We found that a subset of signal transducer and activator of transcription 3 (STAT3) translocated into mitochondria in phagocytes, including macrophages isolated from individuals with sepsis.
Rongqing Li, Xueqin Li, Jie Zhao, Fandong Meng, Chen Yao, Ensi Bao, N. Sun, Xin Chen, Wanpeng Cheng, Hui Hua, Xiangyang Li, Bo Wang, Hui Wang, Xiucheng Pan, Hongjuan You, Jing Yang, T. Ikezoe   +16 more
semanticscholar   +1 more source

IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and development, the tumorigenicity of HCC is involving in multistep and multifactor interactions.
Junnv Xu, Haifeng Lin, Gang Wu, Mingyue Zhu, Mengsen Li   +4 more
semanticscholar   +1 more source

STATs in cancer inflammation and immunity: a leading role for STAT3

Nature Reviews. Cancer, 2009
Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or ...
Hua Yu, D. Pardoll, R. Jove
semanticscholar   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Eggen, BJL, Vellenga, E, Vellenga, Edo,, Vogelzang, Irma, Eggen, BJL; id_orcid, Vogelzang, Irma,, Wierenga, Albertus T.J., Wierenga, Albertus T.J.,, Eggen, Bart J.L.,   +8 more
core   +1 more source

The Role of Transcription Factors in Coronary Artery Disease and Myocardial Infarction

Frontiers in Bioscience-Landmark, 2022
Coronary artery disease (CAD) and its main complication, myocardial infarction (MI), is a complex disease caused by environmental and genetic factors and their interaction.
Chunyan Luo, Yuwen Ruan, Peixue Sun, Haoran Wang, Weihua Yang, Yuankai Gong, Decheng Wang   +6 more
doaj   +1 more source