Results 21 to 30 of about 273,588 (361)
The role of IL-6/JAK2/STAT3 signaling pathway in cancers
Frontiers in Oncology, 2022 Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway.
Bei Huang, Xiaoling Lang, Xihong Li
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Gastric cancer is a common malignant tumor that threatens human health, and its occurrence and development mechanism is a complex process involving multiple genes and multiple signals.
Haobin Li +14 more
doaj +1 more source
Membrane-associated STAT3 and PY-STAT3 in the Cytoplasm [PDF]
Journal of Biological Chemistry, 2006 Signal transduction from the plasma membrane to the nucleus by STAT proteins is widely represented as exclusively a soluble cytosolic process. Using cell-fractionation methods, we observed that approximately 5% of cytoplasmic STAT3 was constitutively associated with the purified early endosome (EE) fraction in human Hep3B liver cells.
Mehul, Shah +5 more
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STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK− ALCL [PDF]
Cancers, 2020 Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular and genetic characterization of PTCLs have helped to delineate differences and similarities between the various subtypes, and the JAK/STAT pathway has been found to play an important oncogenic role.
Emma I. Andersson +10 more
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Frontiers in Immunology, 2021 Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces inflammatory responses via the JAK2/STAT3 pathway.
Hua Zhu +8 more
semanticscholar +1 more source
Cells, 2020 The JAK/STAT3 signaling pathway plays an essential role in various types of cancers. Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition of cancer stem cells (CSCs), and chemoresistance in cancer via enhancing
W. Jin
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background: Non-small cell lung cancer (NSCLC) is the most common malignancy worldwide. MiR-199a-5p has been reported to play important roles in multiple tumors, inclusive of NSCLC.
Xingping Yang +6 more
doaj +1 more source
The role of STAT3 in autophagy [PDF]
Autophagy, 2015 Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular homeostasis in response to a series of extracellular insults. However, these insults may trigger the downstream signaling of another prominent stress responsive pathway, the STAT3 signaling pathway, which has been implicated in ...
You, Liangkun +8 more
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Importance of STAT3 signalling in cancer, metastasis and therapeutic interventions.
Cellular Signalling, 2022 The Signal Transducer and Activator of Transcription 3 (STAT3) protein is encoded on chromosome 17q21. The SH2 and the DNA binding domains are critical structural components of the protein, together with tyrosine and serine residues that initiate ...
Mohamed El-Tanani +5 more
semanticscholar +1 more source
The Deadly Bite of STAT3 [PDF]
Cancer Cell, 2019 The Tasmanian devils' facial tumor disease (DFTD) is a transmissible cancer that spreads by biting and threatens extinction of this marsupial. In this issue of Cancer Cell, Kosack et al. describe how overexpression of ERBB and uncontrolled activation of STAT3 drive DFTD growth and immune evasion.
Schwenzer, H, Fassati, A
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