Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. [PDF]
, 2016 BackgroundHyperactivation of STAT3 via constitutive phosphorylation of tyrosine 705 (Y705) is common in most human cancers, including head and neck squamous carcinoma (HNSCC).
Gooding, William E +5 more
core +6 more sources
The Role of Transcription Factors in Coronary Artery Disease and Myocardial Infarction
Frontiers in Bioscience-Landmark, 2022 Coronary artery disease (CAD) and its main complication, myocardial infarction (MI), is a complex disease caused by environmental and genetic factors and their interaction.
Chunyan Luo +6 more
doaj +1 more source
Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]
, 2003 Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber +36 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background: Non-small cell lung cancer (NSCLC) is the most common malignancy worldwide. MiR-199a-5p has been reported to play important roles in multiple tumors, inclusive of NSCLC.
Xingping Yang +6 more
doaj +1 more source
Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation [PDF]
, 2017 Cell proliferation has generally been considered dispensable for anteroposterior extension of embryonic axis during vertebrate gastrulation. Signal transducer and activator of transcription 3 (Stat3), a conserved controller of cell proliferation ...
Liu, Yinzi +2 more
core +4 more sources
TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]
, 2017 STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien +7 more
core +3 more sources
RBM8A Promotes Glioblastoma Growth and Invasion Through the Notch/STAT3 Pathway
Frontiers in Oncology, 2021 BackgroundGlioblastoma (GBM) is a prevalent brain malignancy with an extremely poor prognosis, which is attributable to its invasive biological behavior. The RNA-binding motif protein 8A (RBM8A) has different effects on various human cancers.
Yan Lin +6 more
doaj +1 more source
Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host [PDF]
, 2017 Purpose: In patients with colorectal cancer (CRC), a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival.
Clark, Jennifer +7 more
core +1 more source
Anti-melanoma SK-Mel-103 cells effect of a natural small molecule, HEP-14
陆军军医大学学报, 2022 Objective To investigate the inhibitory effect of a natural small molecule, HEP-14, on melanoma SK-Mel-103 cells and its underlying mechanism. Methods SK-Mel-103 cells were treated with HEP-14 at different concentrations (2.5~40 μmol/L).
LIU Fang +5 more
doaj +1 more source
Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]
, 2019 Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio +14 more
core +1 more source