Results 21 to 30 of about 229,822 (315)
Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]
, 2003 Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Eggen, BJL +8 more
core +1 more source
The Role of Transcription Factors in Coronary Artery Disease and Myocardial Infarction
Frontiers in Bioscience-Landmark, 2022 Coronary artery disease (CAD) and its main complication, myocardial infarction (MI), is a complex disease caused by environmental and genetic factors and their interaction.
Chunyan Luo +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background: Non-small cell lung cancer (NSCLC) is the most common malignancy worldwide. MiR-199a-5p has been reported to play important roles in multiple tumors, inclusive of NSCLC.
Xingping Yang +6 more
doaj +1 more source
RBM8A Promotes Glioblastoma Growth and Invasion Through the Notch/STAT3 Pathway
Frontiers in Oncology, 2021 BackgroundGlioblastoma (GBM) is a prevalent brain malignancy with an extremely poor prognosis, which is attributable to its invasive biological behavior. The RNA-binding motif protein 8A (RBM8A) has different effects on various human cancers.
Yan Lin +6 more
doaj +1 more source
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
, 2023 Our previous study has revealed that EphA7 was upregulated in patient-derived esophageal squamous cell carcinoma (ESCC) xenografts with hyper-activated STAT3, but its mechanism was still unclear. To assess the association between EphA7 and STAT3, western
Xin Xu (11989) +10 more
core +1 more source
Anti-melanoma SK-Mel-103 cells effect of a natural small molecule, HEP-14
陆军军医大学学报, 2022 Objective To investigate the inhibitory effect of a natural small molecule, HEP-14, on melanoma SK-Mel-103 cells and its underlying mechanism. Methods SK-Mel-103 cells were treated with HEP-14 at different concentrations (2.5~40 μmol/L).
LIU Fang +5 more
doaj +1 more source
IL6-STAT3-HSP90 axis mediates temperature dependency of GCRV infection.
, 2023 (A) Protein-protein interaction network of human STAT3 was analyzed online with the STRING database (http://string-db.org) under a ‘Creative Commons BY 4.0’ license (https://cn.string-db.org/cgi/access?footer_active_subpage=licensing).
Rui Song (331963) +13 more
core +1 more source
The role of STAT3 in autophagy [PDF]
Autophagy, 2015 Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular homeostasis in response to a series of extracellular insults. However, these insults may trigger the downstream signaling of another prominent stress responsive pathway, the STAT3 signaling pathway, which has been implicated in ...
You, Liangkun +8 more
openaire +2 more sources
Frontiers in Pharmacology, 2021 Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy globally and the third leading cause of cancer-related death. Chemotherapy is one of the main methods in treating HCC, while recent studies have found that the resistance of HCC
Han Hong +8 more
doaj +1 more source
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine [PDF]
Open Biology, 2020 Chronic immune activation and inflammation are unwanted consequences of many pathological conditions, since they could lead to tissue damage and immune exhaustion, both of which can worsen the pathological condition status.
Mahmoud Mohammad Yaseen +3 more
doaj +1 more source