Results 31 to 40 of about 229,822 (315)
The Deadly Bite of STAT3 [PDF]
Cancer Cell, 2019 The Tasmanian devils' facial tumor disease (DFTD) is a transmissible cancer that spreads by biting and threatens extinction of this marsupial. In this issue of Cancer Cell, Kosack et al. describe how overexpression of ERBB and uncontrolled activation of STAT3 drive DFTD growth and immune evasion.
Schwenzer, H, Fassati, A
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STAT3 signaling in immunity [PDF]
Cytokine & Growth Factor Reviews, 2016 The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer.
Emily J. Hillmer +3 more
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Frontiers in Cellular Neuroscience, 2014 Emerging research has identified that neuroimmune factors are produced by cells of the central nervous system (CNS) and play critical roles as regulators of CNS function, directors of neurodevelopment and responders to pathological processes.
Donna eGruol, Khanh eVo, Jennifer eBray
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Frontiers in Medicine, 2021 The aim of the present study was to investigate the effect of erythropoietin (EPO) on contrast-induced nephrology (CIN) in vivo and in vitro. Male C57BL/6J mice were divided into four groups: control, CIN (iohexol 6.0 g/kg), EPO (3,000 IU/kg), and CIN ...
Jia Yang +6 more
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Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1
Frontiers in Pharmacology, 2016 Sphingosine 1-phosphate (S1P) is an immune modulatory lipid mediator and has been implicated in numerous pathophysiological processes. S1P is produced by sphingosine kinase 1 (Sphk1) and Sphk2.
Anja eSchwiebs +5 more
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Frontiers in Molecular Biosciences, 2021 Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a major NADH ...
Cuiyan Zhou +5 more
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STAT3: A multifaceted oncogene [PDF]
Proceedings of the National Academy of Sciences, 2006 Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling. These versatile proteins contain a site for specific tyrosine phosphorylation, a modification that results in a conformational rearrangement and dimerization through phosphotyrosine–SH2 ...
D. E. LEVY, INGHIRAMI, Giorgio
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Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]
, 2014 Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S. +32 more
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T cell activation or tolerization: the Yin and Yang of bacterial superantigens
Frontiers in Microbiology, 2015 Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr +3 more
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Frontiers in Neuroscience, 2013 In the mouse hypothalamus, ciliary neurotrophic factor (CNTF) is mainly expressed by ependymal cells and tanycytes of the ependymal layer covering the third ventricle.
Ilenia eSeveri +7 more
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