Results 31 to 40 of about 273,588 (361)
RBM8A Promotes Glioblastoma Growth and Invasion Through the Notch/STAT3 Pathway
Frontiers in Oncology, 2021 BackgroundGlioblastoma (GBM) is a prevalent brain malignancy with an extremely poor prognosis, which is attributable to its invasive biological behavior. The RNA-binding motif protein 8A (RBM8A) has different effects on various human cancers.
Yan Lin +6 more
doaj +1 more source
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
, 2023 Our previous study has revealed that EphA7 was upregulated in patient-derived esophageal squamous cell carcinoma (ESCC) xenografts with hyper-activated STAT3, but its mechanism was still unclear. To assess the association between EphA7 and STAT3, western
Xin Xu (11989) +10 more
core +1 more source
Anti-melanoma SK-Mel-103 cells effect of a natural small molecule, HEP-14
陆军军医大学学报, 2022 Objective To investigate the inhibitory effect of a natural small molecule, HEP-14, on melanoma SK-Mel-103 cells and its underlying mechanism. Methods SK-Mel-103 cells were treated with HEP-14 at different concentrations (2.5~40 μmol/L).
LIU Fang +5 more
doaj +1 more source
STAT3: A multifaceted oncogene [PDF]
Proceedings of the National Academy of Sciences, 2006 Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling. These versatile proteins contain a site for specific tyrosine phosphorylation, a modification that results in a conformational rearrangement and dimerization through phosphotyrosine–SH2 ...
David E, Levy, Giorgio, Inghirami
openaire +2 more sources
Role of STAT3 signaling pathway in breast cancer
Cell Communication and Signaling, 2020 Breast cancer has grown to be the second leading cause of cancer-related deaths in women. Only a few treatment options are available for breast cancer due to the widespread occurrence of chemoresistance, which emphasizes the need to discover and develop ...
Jia-hui Ma, L. Qin, Xia Li
semanticscholar +1 more source
IL6-STAT3-HSP90 axis mediates temperature dependency of GCRV infection.
, 2023 (A) Protein-protein interaction network of human STAT3 was analyzed online with the STRING database (http://string-db.org) under a ‘Creative Commons BY 4.0’ license (https://cn.string-db.org/cgi/access?footer_active_subpage=licensing).
Rui Song (331963) +13 more
core +1 more source
Differential silencing of STAT3 isoforms leads to changes in STAT3 activation
Oncotarget, 2023 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in multiple fundamental biological processes and a key player in cancer development and progression. STAT3 is activated upon tyrosine phosphorylation and is constitutively active in various malignancies; therefore, the expression of pSTAT3 has been recognized ...
Shamir, Inbal +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2021 Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy globally and the third leading cause of cancer-related death. Chemotherapy is one of the main methods in treating HCC, while recent studies have found that the resistance of HCC
Han Hong +8 more
doaj +1 more source
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine [PDF]
Open Biology, 2020 Chronic immune activation and inflammation are unwanted consequences of many pathological conditions, since they could lead to tissue damage and immune exhaustion, both of which can worsen the pathological condition status.
Mahmoud Mohammad Yaseen +3 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2014 Emerging research has identified that neuroimmune factors are produced by cells of the central nervous system (CNS) and play critical roles as regulators of CNS function, directors of neurodevelopment and responders to pathological processes.
Donna eGruol, Khanh eVo, Jennifer eBray
doaj +1 more source