Results 31 to 40 of about 216,448 (216)
Table_3_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx [PDF]
, 2022 Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671) +12 more
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Frontiers in Cellular Neuroscience, 2014 Emerging research has identified that neuroimmune factors are produced by cells of the central nervous system (CNS) and play critical roles as regulators of CNS function, directors of neurodevelopment and responders to pathological processes.
Donna eGruol, Khanh eVo, Jennifer eBray
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The role of STAT3 in autophagy [PDF]
Autophagy, 2015 Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular homeostasis in response to a series of extracellular insults. However, these insults may trigger the downstream signaling of another prominent stress responsive pathway, the STAT3 signaling pathway, which has been implicated in ...
You, Liangkun +8 more
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Frontiers in Medicine, 2021 The aim of the present study was to investigate the effect of erythropoietin (EPO) on contrast-induced nephrology (CIN) in vivo and in vitro. Male C57BL/6J mice were divided into four groups: control, CIN (iohexol 6.0 g/kg), EPO (3,000 IU/kg), and CIN ...
Jia Yang +6 more
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The Deadly Bite of STAT3 [PDF]
Cancer Cell, 2019 The Tasmanian devils' facial tumor disease (DFTD) is a transmissible cancer that spreads by biting and threatens extinction of this marsupial. In this issue of Cancer Cell, Kosack et al. describe how overexpression of ERBB and uncontrolled activation of STAT3 drive DFTD growth and immune evasion.
Schwenzer, H, Fassati, A
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Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]
, 2014 Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S. +32 more
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Table_8_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx [PDF]
, 2022 Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671) +12 more
core +1 more source
Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1
Frontiers in Pharmacology, 2016 Sphingosine 1-phosphate (S1P) is an immune modulatory lipid mediator and has been implicated in numerous pathophysiological processes. S1P is produced by sphingosine kinase 1 (Sphk1) and Sphk2.
Anja eSchwiebs +5 more
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Frontiers in Molecular Biosciences, 2021 Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a major NADH ...
Cuiyan Zhou +5 more
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STAT3: A multifaceted oncogene [PDF]
Proceedings of the National Academy of Sciences, 2006 Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling. These versatile proteins contain a site for specific tyrosine phosphorylation, a modification that results in a conformational rearrangement and dimerization through phosphotyrosine–SH2 ...
David E, Levy, Giorgio, Inghirami
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