Results 1 to 10 of about 833,114 (323)

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]

, 2004
INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Bell, A.K., Davies, C.R., Duffy, M.A., Ferrier, R.K., Gusterson, B.A., Heath, V.J., Morris, J.S., Sandilands, G.P., Stein, T., Weber-Hall, S.J.   +9 more
core  

Intermolecular disulfide bond influences unphosphorylated STAT3 dimerization and function [PDF]

, 2016
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor activated by the phosphorylation of tyrosine 705 in response to many cytokines and growth factors.
Butturini, E, Canetti, D, Chiavegato, G, Cozzolino, F, Dell'Orco, D, Gotte, G, Marino, V, Mariotto, S, Monti, M, Pucci, P   +9 more
core   +1 more source

Identification and characterization of prokineticin receptor 2 splicing variant and its modulation in an animal model of alzheimer's disease [PDF]

, 2019
Prokineticin 2 is a peptide that is widely distributed in the nervous system and influences a variety of brain functions, such as pain, food intake and circadian rhythms.
Fullone, Maria Rosaria, Lattanzi, Roberta, Maftei, Daniela, Miele, Rossella   +3 more
core   +1 more source

The role of p-Stat3 Y705 immunohistochemistry in glioblastoma prognosis

Diagnostic Pathology, 2019
Background In spite of the multimodal treatment used today, glioblastoma is still the most aggressive and lethal cerebral tumour. To increase survival in these patients, novel therapeutic targets must be discovered.
Sergiu Susman, Radu Pîrlog, Daniel Leucuța, Andrei Otto Mitre, Vlad Adrian Padurean, Carmen Melincovici, Ioana Moldovan, Doinița Crișan, Stefan Ioan Florian   +8 more
doaj   +1 more source

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]

, 2015
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam, Chang, Louise, Downes, Michael, Evans, Ronald M, Korytnaya, Evgenia, Krause, Danielle M, Liddle, Christopher, Lumeng, Carey N, Neidert, Adam, Oral, Elif A, Peng, Xiaoling, Poirier, BreAnne, Reilly, Shannon M, Saltiel, Alan R, Uhm, Maeran, Yu, Ruth T, Zamarron, Brian F   +16 more
core   +2 more sources

The Cytokine IL-6 Reactivates Breast Stromal Fibroblasts through Transcription Factor STAT3-dependent Up-regulation of the RNA-binding Protein AUF1*

Journal of Biological Chemistry, 2014
Background: Cancer cells activate their microenvironment through secreting several cytokines. Results: The cytokine IL-6 activates breast stromal fibroblasts through STAT3-dependent up-regulation of the RNA binding protein AUF1, which stabilizes the SDF ...
S. Hendrayani, H. Al-Khalaf, A. Aboussekhra   +2 more
semanticscholar   +1 more source

Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target

International Journal of Biological Sciences, 2011
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation.
Hua Wang, Fouad Lafdil, Xiaoni Kong, Bin Gao
doaj  

Biomolecular condensates in cancer cell biology: interleukin-6-induced cytoplasmic and nuclear STAT3/PY-STAT3 condensates in hepatoma cells

Contemporary Oncology, 2019
We highlight previous incompletely understood cell biology data in the STAT3 signaling field with respect to interleukin-6 (IL-6)-induced activation of this transcription factor in hepatoma cells to generate cytoplasmic and nuclear STAT3 bodies.
Pravin B. Sehgal
doaj   +1 more source

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

STAT3, stem cells, cancer stem cells and p63

Cellular & Molecular Biology Letters, 2018
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells.
Michaela Galoczova, Philip Coates, Borivoj Vojtesek   +2 more
doaj   +1 more source