Results 1 to 10 of about 142,389 (117)

Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis [PDF]

Biomedicines, 2021
Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors.
Young-Ah Kim, Hyun-Ju Kim, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Jin An, Seongjae Bae, Jaechan Leem, Hyun Jin Jung, Kwan-Kyu Park   +8 more
doaj   +2 more sources

Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]

Cell Death and Disease
Signal transducer and activator of transcription 3 (STAT3) is widely recognized as an attractive target for cancer therapy due to its significant role in the initiation and progression of tumorigenesis.
Shiqing Li, Xin Wang, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Tao Zeng, Qi Chen, Chunsen Li, Chunhua Lu, Huanghao Yang   +10 more
doaj   +2 more sources

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

Frontiers in Cardiovascular Medicine, 2022
Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu, Lan Wu, Zhizheng Li, Yanfei Li, Yanfei Li   +4 more
doaj   +1 more source

A STAT3 protein complex required for mitochondrial mRNA stability and cancer

Cell Reports, 2023
Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its activity
C. Dilanka Fernando, W. Samantha N. Jayasekara, Chaitanya Inampudi, Maija R.J. Kohonen-Corish, Wendy A. Cooper, Traude H. Beilharz, Tracy M. Josephs, Daniel J. Garama, Daniel J. Gough   +8 more
doaj   +1 more source

Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]

Cell Death and Disease
Shiqing Li, Xin Wang, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Tao Zeng, Qi Chen, Chunsen Li, Chunhua Lu, Huanghao Yang   +10 more
doaj   +2 more sources

STAT3 and p63 in the Regulation of Cancer Stemness

Frontiers in Genetics, 2022
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in ...
Shixiong Wei, Jialin Li, Mingbo Tang, Kewei Zhang, Xinliang Gao, Linan Fang, Wei Liu   +6 more
doaj   +1 more source

Targeting the transcriptional activity of STAT3 by a novel fusion protein

BMC Cancer, 2022
Background The continuous activation of transcription factors drives many diseases, including tumors, autoimmune disease, neurodegenerative disease, and male infertility.
Yanqiong Chen, Wenting Zhang, Xiufeng Bai, Yi Liu   +3 more
doaj   +1 more source

The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions

Biomedicines, 2021
STAT3 is an important transcription factor that regulates cell growth and proliferation by regulating gene transcription of a plethora of genes. This protein also has many roles in cancer progression and several tumors such as prostate, lung, breast, and
Annachiara Tesoriere, Alberto Dinarello, Francesco Argenton   +2 more
doaj   +1 more source

Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

Cell Reports, 2022
Summary: Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis.
Amrendra K. Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bhatt, Pratyusha Chaluvadi, Manoj K. Gupta, Sujal I. Shah, Venkata S. Sabbisetti, Ana Maria Waaga-Gasser, David A. Frank, Gopal Murugaiyan, Joseph V. Bonventre, Li-Li Hsiao   +20 more
doaj   +1 more source

Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

Biomedical Journal, 2021
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation.
Laura Faletti, Stephan Ehl, Maximilian Heeg   +2 more
doaj   +1 more source