Results 31 to 40 of about 4,681,955 (286)

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [PDF]

Blood, 1994
Abstract Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates proliferation and differentiation of progenitor cells of neutrophils by signaling through its receptor (G-CSFR). Although the G- CSFR belongs to the cytokine receptor superfamily, which lacks an intracellular kinase domain, G-CSF-induced tyrosine ...
S S, Tian, P, Lamb, H M, Seidel, R B, Stein, J, Rosen   +4 more
openaire   +3 more sources

Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

Biomedical Journal, 2021
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation.
Laura Faletti, Stephan Ehl, Maximilian Heeg   +2 more
doaj   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Eggen, BJL, Vellenga, E, Vellenga, Edo,, Vogelzang, Irma, Eggen, BJL; id_orcid, Vogelzang, Irma,, Wierenga, Albertus T.J., Wierenga, Albertus T.J.,, Eggen, Bart J.L.,   +8 more
core   +1 more source

An Update on the Multifaceted Roles of STAT3 in the Heart

Frontiers in Cardiovascular Medicine, 2019
Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and transcription factor that plays important protective roles in the heart.
Zeina Harhous, Zeina Harhous, Zeina Harhous, George W. Booz, Michel Ovize, Michel Ovize, Gabriel Bidaux, Gabriel Bidaux, Mazen Kurdi   +8 more
doaj   +1 more source

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells [PDF]

, 2012
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However,
Miao, T, Bhullar, P, Ghaffari, Emma, Liu, Mengya, Liu, M, Wang, Ping, Miao, Tizong, Li, Suling, Wang, P, Sebastian, M, Ghaffari, E, Sebastian, Meera, Symonds, Alistair L.J., Li, S, Symonds, ALJ, Bhullar, Punamdip   +15 more
core   +1 more source

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

Cell Reports, 2016
Summary: 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome.
Pradeep Chaluvally-Raghavan, Kang Jin Jeong, Sunila Pradeep, Andreia Machado Silva, Shuangxing Yu, Wenbin Liu, Tyler Moss, Cristian Rodriguez-Aguayo, Dong Zhang, Prahlad Ram, Jinsong Liu, Yiling Lu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood, Gordon B. Mills   +15 more
doaj   +1 more source

Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma

Cells, 2022
Multiple myeloma (MM) is the second most common hematological malignancy, characterized by an abnormal accumulation of plasma cells in the bone marrow. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that ...
Jianbiao Zhou, Wee-Joo Chng
doaj   +1 more source

Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a [PDF]

Journal of Biological Chemistry, 2002
Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes. This transcriptional activation by STAT3 proteins
Sandrine, Giraud, Frédéric, Bienvenu, Sylvie, Avril, Hugues, Gascan, David M, Heery, Olivier, Coqueret   +5 more
openaire   +2 more sources

Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein [PDF]

, 2005
Tumors have evolved elaborate mechanisms for evading immune detection, such as production of immunoinhibitory cytokines and down-regulation of major histocompatibility complex (MHC) expression.
Hubank, M, Antigoni Papanastasiou, Nabarro, S, Sebire, N, Himoudi, N, Papanastasiou, A, Blundell, MP, Gibson, S, Gilmour, K, Anderson, J, Adrian Thrasher, Neil Sebire, John Anderson, Mike Hubank, Nourredine Himoudi, Kimberly Gilmour, Sian Gibson, Canderan, G, Stephen Nabarro, Glenda Canderan, Thrasher, A, Michael P. Blundell   +21 more
core   +1 more source

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation

Frontiers in Immunology, 2020
Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation processing, but the mechanism of its regulation mostly remains limited to Janus kinase (JAK)-mediated phosphorylation.
Hui Gong, Haoran Tai, Haoran Tai, Ning Huang, Peng Xiao, Chunfen Mo, Chunfen Mo, Xiaobo Wang, Xiaojuan Han, Jiao Zhou, Honghan Chen, Xiaoqiang Tang, Tingting Zhao, Weitong Xu, Chuhui Gong, Gongchang Zhang, Yu Yang, Shuang Wang, Hengyi Xiao   +18 more
doaj   +1 more source