Results 31 to 40 of about 833,114 (323)

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

Frontiers in Cardiovascular Medicine, 2022
Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu, Lan Wu, Zhizheng Li, Yanfei Li, Yanfei Li   +4 more
doaj   +1 more source

A STAT3 protein complex required for mitochondrial mRNA stability and cancer

Cell Reports, 2023
Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its activity
C. Dilanka Fernando, W. Samantha N. Jayasekara, Chaitanya Inampudi, Maija R.J. Kohonen-Corish, Wendy A. Cooper, Traude H. Beilharz, Tracy M. Josephs, Daniel J. Garama, Daniel J. Gough   +8 more
doaj   +1 more source

STAT3 and p63 in the Regulation of Cancer Stemness

Frontiers in Genetics, 2022
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in ...
Shixiong Wei, Jialin Li, Mingbo Tang, Kewei Zhang, Xinliang Gao, Linan Fang, Wei Liu   +6 more
doaj   +1 more source

Targeting the transcriptional activity of STAT3 by a novel fusion protein

BMC Cancer, 2022
Background The continuous activation of transcription factors drives many diseases, including tumors, autoimmune disease, neurodegenerative disease, and male infertility.
Yanqiong Chen, Wenting Zhang, Xiufeng Bai, Yi Liu   +3 more
doaj   +1 more source

Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection.

Immunity, 2014
Xiaohuan Guo, J. Qiu, T. Tu, Xuanming Yang, Liufu Deng, R. Anders, Liang Zhou, yang-xin fu   +7 more
semanticscholar   +3 more sources

The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions

Biomedicines, 2021
STAT3 is an important transcription factor that regulates cell growth and proliferation by regulating gene transcription of a plethora of genes. This protein also has many roles in cancer progression and several tumors such as prostate, lung, breast, and
Annachiara Tesoriere, Alberto Dinarello, Francesco Argenton   +2 more
doaj   +1 more source

Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

Cell Reports, 2022
Summary: Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis.
Amrendra K. Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bhatt, Pratyusha Chaluvadi, Manoj K. Gupta, Sujal I. Shah, Venkata S. Sabbisetti, Ana Maria Waaga-Gasser, David A. Frank, Gopal Murugaiyan, Joseph V. Bonventre, Li-Li Hsiao   +20 more
doaj   +1 more source

Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

Biomedical Journal, 2021
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation.
Laura Faletti, Stephan Ehl, Maximilian Heeg   +2 more
doaj   +1 more source

Gas6 Induces Mesangial Cell Proliferation via Latent Transcription Factor STAT3 [PDF]

Journal of Biological Chemistry, 2001
Mesangial cell proliferation is essential for the pathogenesis and progression of glomerular disease. Previously, we showed that Gas6 plays a pivotal role in mesangial cell proliferation in vitro and in vivo. In the present study, we identified downstream targets of Gas6 signaling to examine the role in mesangial cell proliferation in vitro and in vivo.
M, Yanagita, H, Arai, T, Nakano, K, Ohashi, K, Mizuno, A, Fukatsu, T, Doi, T, Kita   +7 more
openaire   +2 more sources

Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma

Cells, 2022
Multiple myeloma (MM) is the second most common hematological malignancy, characterized by an abnormal accumulation of plasma cells in the bone marrow. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that ...
Jianbiao Zhou, Wee-Joo Chng
doaj   +1 more source