Results 21 to 30 of about 4,681,955 (286)

Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor. [PDF]

BMC Mol Cell Biol, 2022
Abstract Background Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that promotes cell proliferation and immunomodulation in untransformed cells and maintains stemness of transformed cells, facilitating invasion and metastasis.
Behrendsen LS, Menon PR, Khan MJ, Gregus A, Wirths O, Meyer T, Staab J.   +6 more
europepmc   +5 more sources

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

Frontiers in Cardiovascular Medicine, 2022
Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu, Lan Wu, Zhizheng Li, Yanfei Li, Yanfei Li   +4 more
doaj   +1 more source

Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]

Cell Death and Disease
Shiqing Li, Xin Wang, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Tao Zeng, Qi Chen, Chunsen Li, Chunhua Lu, Huanghao Yang   +10 more
doaj   +2 more sources

A STAT3 protein complex required for mitochondrial mRNA stability and cancer

Cell Reports, 2023
Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its activity
C. Dilanka Fernando, W. Samantha N. Jayasekara, Chaitanya Inampudi, Maija R.J. Kohonen-Corish, Wendy A. Cooper, Traude H. Beilharz, Tracy M. Josephs, Daniel J. Garama, Daniel J. Gough   +8 more
doaj   +1 more source

STAT3 and p63 in the Regulation of Cancer Stemness

Frontiers in Genetics, 2022
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in ...
Shixiong Wei, Jialin Li, Mingbo Tang, Kewei Zhang, Xinliang Gao, Linan Fang, Wei Liu   +6 more
doaj   +1 more source

Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening. [PDF]

ACS Med Chem Lett
The STAT family of transcription factors are important signaling hubs, with several of them, particularly STAT3, being emerging oncotargets already investigated in clinical trials. The modular structure of STAT3 nominates several of its protein domains as possible drug targets, but their exploitation with potential small-molecule inhibitors has been ...
Szalai TV, di Lorenzo V, Péczka N, Mihalovits LM, Petri L, Ashraf QF, de Araujo ED, Honti V, Bajusz D, Keserű GM.   +9 more
europepmc   +4 more sources

Targeting the transcriptional activity of STAT3 by a novel fusion protein

BMC Cancer, 2022
Background The continuous activation of transcription factors drives many diseases, including tumors, autoimmune disease, neurodegenerative disease, and male infertility.
Yanqiong Chen, Wenting Zhang, Xiufeng Bai, Yi Liu   +3 more
doaj   +1 more source

The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions

Biomedicines, 2021
STAT3 is an important transcription factor that regulates cell growth and proliferation by regulating gene transcription of a plethora of genes. This protein also has many roles in cancer progression and several tumors such as prostate, lung, breast, and
Annachiara Tesoriere, Alberto Dinarello, Francesco Argenton   +2 more
doaj   +1 more source

Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

Cell Reports, 2022
Summary: Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis.
Amrendra K. Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bhatt, Pratyusha Chaluvadi, Manoj K. Gupta, Sujal I. Shah, Venkata S. Sabbisetti, Ana Maria Waaga-Gasser, David A. Frank, Gopal Murugaiyan, Joseph V. Bonventre, Li-Li Hsiao   +20 more
doaj   +1 more source

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription [PDF]

Journal of Biological Chemistry, 1996
The 89-kDa STAT3 protein is a latent transcription factor which is activated in response to cytokines (interleukin (IL)-5 and -6) and growth factors (epidermal growth factor). Binding of IL-5 to its specific receptor activates JAK2 which leads to the tyrosine phosphorylation of STAT3 proteins.
Caldenhoven, Eric, Dijk, Thamar B. van, Solari, Roberto, Armstrong, John, Raaijmakers, J.A.M., Lammers, J.W.J., Koenderman, L., Groot, Rolf P. de   +7 more
openaire   +4 more sources