Results 21 to 30 of about 142,538 (255)
Frontiers in Immunology, 2020 Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation processing, but the mechanism of its regulation mostly remains limited to Janus kinase (JAK)-mediated phosphorylation.
Hui Gong +18 more
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A model for how signal duration can determine distinct outcomes of gene transcription programs. [PDF]
PLoS ONE, 2012 The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood.
Kevin D Fowler +2 more
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Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a [PDF]
Journal of Biological Chemistry, 2002 Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes. This transcriptional activation by STAT3 proteins
Sandrine, Giraud +5 more
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Identification of novel regulators of STAT3 activity.
PLoS ONE, 2020 STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri +4 more
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Journal of Molecular Biology, 2021 Chaperonin Containing Tailless complex polypeptide 1 (CCT) is an essential molecular chaperone required for the folding of the abundant proteins actin and tubulin. The CCT oligomer also folds a range of other proteins and participates in non-folding activities such as providing assembly support for complexes of the von Hippel Lindau tumor suppressor ...
Josefine, Vallin +2 more
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Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation.
Jimin Shin +12 more
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STAT3 plays an important role in DNA replication by turning on WDHD1
Cell & Bioscience, 2021 Background Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that plays a key role in many cellular processes such as cell growth and cancer.
Yunying Zhou, Jason J. Chen
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Neoplasia: An International Journal for Oncology Research, 2015 The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. Here
Irina Kiprianova +6 more
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Prediction and experimental validation of novel STAT3 target genes in human cancer cells. [PDF]
PLoS ONE, 2009 The comprehensive identification of functional transcription factor binding sites (TFBSs) is an important step in understanding complex transcriptional regulatory networks.
Young Min Oh +4 more
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Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 [PDF]
Journal of Biological Chemistry, 1995 The receptor for interleukin-5 (IL-5R) is composed of a unique alpha chain (IL-5R alpha) expressed on eosinophils and basophils, associated with a beta c subunit, which is shared by the receptors for IL-3 and granulocyte macrophage-colony stimulating factor. One of the molecular events activated via the IL-5R is the JAK/STAT signaling pathway.
Caldenhoven, Eric +5 more
openaire +3 more sources