Results 21 to 30 of about 833,114 (323)

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. [PDF]

Int J Mol Sci, 2018
Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that ...
Lee DS, Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE.   +5 more
europepmc   +6 more sources

Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]

Cell Death and Disease
Shiqing Li, Xin Wang, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Tao Zeng, Qi Chen, Chunsen Li, Chunhua Lu, Huanghao Yang   +10 more
doaj   +3 more sources

Activation of Stat3 Transcription Factor by Herpesvirus Saimiri STP-A Oncoprotein [PDF]

Journal of Virology, 2004
ABSTRACT The saimiri transforming protein (STP) oncogene of Herpesvirus saimiri subgroup A strain 11 (STP-A11) is not required for viral replication but is required for lymphoid cell immortalization in culture and lymphoma induction in primates. We previously showed that STP-A11 interacts with cellular Src
Y. Chung, Nam-Hyuk Cho, M. I. García, Sun-Hwa Lee, P. Feng, Jae U. Jung   +5 more
semanticscholar   +3 more sources

Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor [PDF]

Oncogene, 2014
Approximately 50% of melanomas depend on mutant B-RAF for proliferation, metastasis and survival. The inhibition of oncogenic B-RAF with highly targeted compounds has produced remarkable albeit short-lived clinical responses in B-RAF mutant melanoma patients.
Therese M. Becker, Suzanah C. Boyd, Branka Mijatov, K. Gowrishankar, Stephanie T. Snoyman, G. Pupo, R. Scolyer, Graham J. Mann, R. Kefford, Xu Dong Zhang, H. Rizos   +10 more
semanticscholar   +3 more sources

IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.

Immunity, 2014
Little is known about how the immune system impacts human colorectal cancer invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient colorectal cancer tissues that was produced predominantly by CD4(+) T cells.
Ilona Kryczek, Yan-wei Lin, N. Nagarsheth, D. Peng, Lili Zhao, Ende Zhao, Linda Vatan, Wojciech Szeliga, Y. Dou, S. Owens, W. Zgodziński, M. Majewski, G. Wallner, Jingyuan Fang, E. Huang, W. Zou   +15 more
semanticscholar   +3 more sources

The Transcription Factor STAT3 Is Required for T Helper 2 Cell Development [PDF]

Immunity, 2011
Signal transducer and activator of transcription (STAT) family members direct the differentiation of T helper cells, with specific STAT proteins promoting distinct effector subsets. STAT6 is required for the development of T helper 2 (Th2) cells, whereas STAT3 promotes differentiation of Th17 and follicular helper T cell subsets.
Stritesky, Gretta L., Muthukrishnan, Rajarajeswari, Sehra, Sarita, Goswami, Ritobrata, Pham, Duy, Travers, Jared, Nguyen, Evelyn T., Levy, David E., Kaplan, Mark H.   +8 more
openaire   +4 more sources

Role of Unphosphorylated Transcription Factor STAT3 in Late Cerebral Ischemia after Subarachnoid Hemorrhage [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2014
Molecular mechanisms behind increased cerebral vasospasm and local inflammation in late cerebral ischemia after subarachnoid hemorrhage (SAH) are poorly elucidated. Using system biology tools and experimental SAH models, we have identified signal transducer and activator of transcription 3 (STAT3) transcription factor as a possible major regulatory ...
A. K. Samraj, A. H. Müller, A. Grell, L. Edvinsson   +3 more
semanticscholar   +4 more sources

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

Immunity, 2010
STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data linking STAT3 with inflammatory bowel disease, exactly how it contributes to chronic intestinal ...
L. Durant, W. Watford, Haydeé L. Ramos, A. Laurence, G. Vahedi, Lai Wei, Hayato Takahashi, Hong-Wei Sun, Y. Kanno, F. Powrie, J. O’Shea   +10 more
semanticscholar   +3 more sources

A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.

Immunity, 2011
A. M. Siegel, J. Heimall, A. Freeman, A. Hsu, E. Brittain, J. Brenchley, D. Douek, G. Fahle, J. Cohen, S. Holland, J. Milner   +10 more
semanticscholar   +3 more sources

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation.

Immunity, 2016
Vinit Kumar, P. Cheng, T. Condamine, Sridevi Mony, L. Languino, J. Mccaffrey, N. Hockstein, M. Guarino, G. Masters, E. Penman, F. Denstman, Xiaowei Xu, D. Altieri, H. Du, Cong Yan, D. Gabrilovich   +15 more
semanticscholar   +3 more sources