Results 11 to 20 of about 4,681,955 (286)

Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]

Cell Death and Disease
Signal transducer and activator of transcription 3 (STAT3) is widely recognized as an attractive target for cancer therapy due to its significant role in the initiation and progression of tumorigenesis.
Shiqing Li, Xin Wang, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Tao Zeng, Qi Chen, Chunsen Li, Chunhua Lu, Huanghao Yang   +10 more
doaj   +4 more sources

Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis [PDF]

Biomedicines, 2021
Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors.
Young-Ah Kim, Hyun-Ju Kim, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Jin An, Seongjae Bae, Jaechan Leem, Hyun Jin Jung, Kwan-Kyu Park   +8 more
doaj   +2 more sources

CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3

Neoplasia: An International Journal for Oncology Research, 2020
The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, through ...
Susana P. Egusquiaguirre, Suhu Liu, Isidora Tošić, Kevin Jiang, Sarah R. Walker, Maria Nicolais, Tzuen Yih Saw, Michael Xiang, Katarina Bartel, Erik A. Nelson, David A. Frank   +10 more
doaj   +3 more sources

Molecular Modulators of the Oncogenic Transcription Factor STAT3

, 2015
Since the neoplastic phenotype of a cell is largely driven by aberrant gene expression patterns, increasing attention has been focused on transcription factors that regulate critical mediators of tumorigenesis such as signal transducer and activator of transcription 3 (STAT3). Here we investigate how the inappropriate activation of STAT3 contributes to
Yeh, Jennifer
core   +8 more sources

The regulatory relationship between transcription factor STAT3 and noncoding RNA

Cellular & Molecular Biology Letters
Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance.
Siyi Liu, Wentao Li, Lin Liang, Yanhong Zhou, Yanling Li   +4 more
doaj   +3 more sources

Targeting transcription factor STAT3 for cancer prevention and therapy

Pharmacology & Therapeutics, 2016
Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and ...
Chai, E., Shanmugam, M., Arfuso, Frank, Dharmarajan, Arunasalam, Wang, C., Kumar, A., Samy, R., Lim, L., Wang, L., Goh, B., Ahn, K., Hui, K., Sethi, G.   +12 more
openaire   +4 more sources

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]

, 2004
INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Duffy, M.A., Heath, V.J., Bell, A.K., Davies, C.R., Sandilands, G.P., Gusterson, B.A., Morris, J.S., Weber-Hall, S.J., Ferrier, R.K., Stein, T.   +9 more
core   +8 more sources

STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma

Cancer Management and Research, 2018
Zhaoyong Liu,1,* Ying Zhang,2,* Yelong Chen,1 Youbin Lin,1 Zhen Lin,2 Hu Wang1 1Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; 2Department of Pathology, Shantou University ...
Liu Z, Zhang Y, Chen Y, Lin Y, Lin Z, Wang H   +5 more
doaj   +1 more source

Biomolecular condensates in cancer cell biology: interleukin-6-induced cytoplasmic and nuclear STAT3/PY-STAT3 condensates in hepatoma cells

Contemporary Oncology, 2019
We highlight previous incompletely understood cell biology data in the STAT3 signaling field with respect to interleukin-6 (IL-6)-induced activation of this transcription factor in hepatoma cells to generate cytoplasmic and nuclear STAT3 bodies.
Pravin B. Sehgal
doaj   +2 more sources

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. [PDF]

Int J Mol Sci, 2018
Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that ...
Lee DS, Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE.   +5 more
europepmc   +6 more sources