Results 11 to 20 of about 142,538 (255)

CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3

Neoplasia: An International Journal for Oncology Research, 2020
The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, through ...
Susana P. Egusquiaguirre, Suhu Liu, Isidora Tošić, Kevin Jiang, Sarah R. Walker, Maria Nicolais, Tzuen Yih Saw, Michael Xiang, Katarina Bartel, Erik A. Nelson, David A. Frank   +10 more
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The regulatory relationship between transcription factor STAT3 and noncoding RNA

Cellular & Molecular Biology Letters
Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance.
Siyi Liu, Wentao Li, Lin Liang, Yanhong Zhou, Yanling Li   +4 more
doaj   +3 more sources

Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor. [PDF]

BMC Mol Cell Biol, 2022
Abstract Background Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that promotes cell proliferation and immunomodulation in untransformed cells and maintains stemness of transformed cells, facilitating invasion and metastasis.
Behrendsen LS, Menon PR, Khan MJ, Gregus A, Wirths O, Meyer T, Staab J.   +6 more
europepmc   +5 more sources

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. [PDF]

Int J Mol Sci, 2018
Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that ...
Lee DS, Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE.   +5 more
europepmc   +6 more sources

Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening. [PDF]

ACS Med Chem Lett
The STAT family of transcription factors are important signaling hubs, with several of them, particularly STAT3, being emerging oncotargets already investigated in clinical trials. The modular structure of STAT3 nominates several of its protein domains as possible drug targets, but their exploitation with potential small-molecule inhibitors has been ...
Szalai TV, di Lorenzo V, Péczka N, Mihalovits LM, Petri L, Ashraf QF, de Araujo ED, Honti V, Bajusz D, Keserű GM.   +9 more
europepmc   +4 more sources

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription [PDF]

Journal of Biological Chemistry, 1996
The 89-kDa STAT3 protein is a latent transcription factor which is activated in response to cytokines (interleukin (IL)-5 and -6) and growth factors (epidermal growth factor). Binding of IL-5 to its specific receptor activates JAK2 which leads to the tyrosine phosphorylation of STAT3 proteins.
Caldenhoven, Eric, Dijk, Thamar B. van, Solari, Roberto, Armstrong, John, Raaijmakers, J.A.M., Lammers, J.W.J., Koenderman, L., Groot, Rolf P. de   +7 more
openaire   +4 more sources

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [PDF]

Blood, 1994
Abstract Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates proliferation and differentiation of progenitor cells of neutrophils by signaling through its receptor (G-CSFR). Although the G- CSFR belongs to the cytokine receptor superfamily, which lacks an intracellular kinase domain, G-CSF-induced tyrosine ...
S S, Tian, P, Lamb, H M, Seidel, R B, Stein, J, Rosen   +4 more
openaire   +3 more sources

An Update on the Multifaceted Roles of STAT3 in the Heart

Frontiers in Cardiovascular Medicine, 2019
Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and transcription factor that plays important protective roles in the heart.
Zeina Harhous, Zeina Harhous, Zeina Harhous, George W. Booz, Michel Ovize, Michel Ovize, Gabriel Bidaux, Gabriel Bidaux, Mazen Kurdi   +8 more
doaj   +1 more source

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

Cell Reports, 2016
Summary: 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome.
Pradeep Chaluvally-Raghavan, Kang Jin Jeong, Sunila Pradeep, Andreia Machado Silva, Shuangxing Yu, Wenbin Liu, Tyler Moss, Cristian Rodriguez-Aguayo, Dong Zhang, Prahlad Ram, Jinsong Liu, Yiling Lu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood, Gordon B. Mills   +15 more
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Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma

Cells, 2022
Multiple myeloma (MM) is the second most common hematological malignancy, characterized by an abnormal accumulation of plasma cells in the bone marrow. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that ...
Jianbiao Zhou, Wee-Joo Chng
doaj   +1 more source