Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]
Cell Death and DiseaseSignal transducer and activator of transcription 3 (STAT3) is widely recognized as an attractive target for cancer therapy due to its significant role in the initiation and progression of tumorigenesis.
Shiqing Li +10 more
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The regulatory relationship between transcription factor STAT3 and noncoding RNA
Cellular & Molecular Biology LettersSignal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance.
Siyi Liu +4 more
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Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening. [PDF]
ACS Med Chem LettThe STAT family of transcription factors are important signaling hubs, with several of them, particularly STAT3, being emerging oncotargets already investigated in clinical trials.
Szalai TV +9 more
europepmc +3 more sources
CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3
Neoplasia: An International Journal for Oncology Research, 2020 The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, through ...
Susana P. Egusquiaguirre +10 more
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Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention [PDF]
Cancers, 2014 Signal Transducers and Activators of Transcription (STATs) are a family of transcription factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory responses, and angiogenesis.
Ailian Xiong +4 more
semanticscholar +5 more sources
Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis [PDF]
Biomedicines, 2021 Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors.
Young-Ah Kim +8 more
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Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [PDF]
Blood, 1994 Abstract Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates proliferation and differentiation of progenitor cells of neutrophils by signaling through its receptor (G-CSFR). Although the G- CSFR belongs to the cytokine receptor superfamily, which lacks an intracellular kinase domain, G-CSF-induced tyrosine ...
S. Tian +4 more
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Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA* [PDF]
Journal of Biological Chemistry, 2012 Background: Unphosphorylated STAT3 (U-STAT3) regulates gene expression, but the mechanisms of its DNA binding are not fully understood. Results: U-STAT3 binds to the same γ-activated sequence (GAS) DNA-binding site as phosphorylated STAT3.
O. Timofeeva +12 more
semanticscholar +3 more sources
Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a* [PDF]
Journal of Biological Chemistry, 2002 Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation.
Sandrine Giraud +5 more
semanticscholar +3 more sources
Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone (*) [PDF]
Journal of Biological Chemistry, 1995 The mechanisms by which the binding of growth hormone (GH) to its cell surface receptor elicits changes in gene transcription are largely unknown. The transcription factor Stat1/p91 has been shown to be activated by GH.
G. Campbell +5 more
semanticscholar +3 more sources