Results 41 to 50 of about 833,114 (323)

Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]

, 2019
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R, Johnson, Daniel E, Lau, Yue-Ting K, Ramaiyer, Malini   +3 more
core   +2 more sources

An Update on the Multifaceted Roles of STAT3 in the Heart

Frontiers in Cardiovascular Medicine, 2019
Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and transcription factor that plays important protective roles in the heart.
Zeina Harhous, Zeina Harhous, Zeina Harhous, George W. Booz, Michel Ovize, Michel Ovize, Gabriel Bidaux, Gabriel Bidaux, Mazen Kurdi   +8 more
doaj   +1 more source

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]

, 2017
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien, De Cauwer, Lode, Icardi, Laura, Mori, Raffaele, Peelman, Frank, Tavernier, Jan, Van Der Heyden, José, Wauman, Joris   +7 more
core   +3 more sources

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 [PDF]

Journal of Biological Chemistry, 1995
The receptor for interleukin-5 (IL-5R) is composed of a unique alpha chain (IL-5R alpha) expressed on eosinophils and basophils, associated with a beta c subunit, which is shared by the receptors for IL-3 and granulocyte macrophage-colony stimulating factor. One of the molecular events activated via the IL-5R is the JAK/STAT signaling pathway.
Caldenhoven, Eric, Dijk, Thamar B. van, Raaijmakers, J.A.M., Lammers, J.W.J., Koenderman, L., Groot, Rolf P. de   +5 more
openaire   +3 more sources

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

Cell Reports, 2016
Summary: 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome.
Pradeep Chaluvally-Raghavan, Kang Jin Jeong, Sunila Pradeep, Andreia Machado Silva, Shuangxing Yu, Wenbin Liu, Tyler Moss, Cristian Rodriguez-Aguayo, Dong Zhang, Prahlad Ram, Jinsong Liu, Yiling Lu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood, Gordon B. Mills   +15 more
doaj   +1 more source

Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor [PDF]

, 2013
Self-renewal of pluripotent mouse embryonic stem (ES) cells is sustained by the cytokine leukaemia inhibitory factor (LIF) acting through the transcription factor Stat3.
Bertone, P, Martello, G, Smith, A
core   +1 more source

CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

Immunity, 2016
Chunyan Zhang, H. Xin, Wang Zhang, P. Yazaki, Zhifang Zhang, Keith Le, Wenzhao Li, Heehyoung Lee, L. Kwak, S. Forman, R. Jove, Hua Yu   +11 more
semanticscholar   +3 more sources

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation

Frontiers in Immunology, 2020
Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation processing, but the mechanism of its regulation mostly remains limited to Janus kinase (JAK)-mediated phosphorylation.
Hui Gong, Haoran Tai, Haoran Tai, Ning Huang, Peng Xiao, Chunfen Mo, Chunfen Mo, Xiaobo Wang, Xiaojuan Han, Jiao Zhou, Honghan Chen, Xiaoqiang Tang, Tingting Zhao, Weitong Xu, Chuhui Gong, Gongchang Zhang, Yu Yang, Shuang Wang, Hengyi Xiao   +18 more
doaj   +1 more source

Signal Transducer and Activator of Transcription 3 (STAT3) Regulates Collagen-Induced Platelet Aggregation Independently of Its Transcription Factor Activity

Circulation, 2013
Zhou Zhou, F. Gushiken, Douglas D Bolgiano, Breia J. Salsbery, N. Aghakasiri, N. Jing, Xiaoping Wu, K. Vijayan, R. Rumbaut, Roberto Adachi, José A López, José A López, Jing-fei Dong, J. Dong, J. Dong   +14 more
semanticscholar   +3 more sources

Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation.
Jimin Shin, Hyo-Jeong Lee, Deok-Beom Jung, Ji Hoon Jung, Hyo-Jung Lee, Eun-Ok Lee, Seok Geun Lee, Beom Sang Shim, Seung Hoon Choi, Seong Gyu Ko, Kwang Seok Ahn, Soo-Jin Jeong, Sung-Hoon Kim   +12 more
doaj   +1 more source