Results 41 to 50 of about 4,681,955 (286)

A model for how signal duration can determine distinct outcomes of gene transcription programs. [PDF]

PLoS ONE, 2012
The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood.
Kevin D Fowler, Vijay K Kuchroo, Arup K Chakraborty   +2 more
doaj   +1 more source

Identification of novel regulators of STAT3 activity.

PLoS ONE, 2020
STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri, Heikki Kuusanmäki, Arjan J van Adrichem, Meri Kaustio, Krister Wennerberg   +4 more
doaj   +1 more source

Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]

, 2014
Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S., Faratian Dana, Huang Rui, Sims Andrew H., Dana Faratian (171110), Simon P. Langdon, Danielle Wilson (550968), David J. Harrison (171106), Jeremy S. Thomas, Dana Faratian, Rui Huang, Wilson Danielle, Harrison David J., David J. Harrison, Danielle Wilson, Simon P Langdon, Thomas, Jeremy S, Sims, Andrew H, Andrew H. Sims (108040), Harrison, David J, Rui Huang (141490), Huang, Rui, Simon P. Langdon (207293), Wilson, Danielle, David J Harrison, Thomas, Jeremy, Langdon Simon P., Faratian, Dana, Andrew H. Sims, Andrew H Sims, Jeremy S Thomas, Jeremy S. Thomas (550969), Langdon, Simon P   +32 more
core   +2 more sources

Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation.
Jimin Shin, Hyo-Jeong Lee, Deok-Beom Jung, Ji Hoon Jung, Hyo-Jung Lee, Eun-Ok Lee, Seok Geun Lee, Beom Sang Shim, Seung Hoon Choi, Seong Gyu Ko, Kwang Seok Ahn, Soo-Jin Jeong, Sung-Hoon Kim   +12 more
doaj   +1 more source

Sequestration of the Transcription Factor STAT3 by the Molecular Chaperone CCT: A Potential Mechanism for Modulation of STAT3 Phosphorylation

Journal of Molecular Biology, 2021
Chaperonin Containing Tailless complex polypeptide 1 (CCT) is an essential molecular chaperone required for the folding of the abundant proteins actin and tubulin. The CCT oligomer also folds a range of other proteins and participates in non-folding activities such as providing assembly support for complexes of the von Hippel Lindau tumor suppressor ...
Josefine, Vallin, Carmen M, Córdoba-Beldad, Julie, Grantham   +2 more
openaire   +2 more sources

STAT3 plays an important role in DNA replication by turning on WDHD1

Cell & Bioscience, 2021
Background Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that plays a key role in many cellular processes such as cell growth and cancer.
Yunying Zhou, Jason J. Chen
doaj   +1 more source

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 [PDF]

Journal of Biological Chemistry, 1995
The receptor for interleukin-5 (IL-5R) is composed of a unique alpha chain (IL-5R alpha) expressed on eosinophils and basophils, associated with a beta c subunit, which is shared by the receptors for IL-3 and granulocyte macrophage-colony stimulating factor. One of the molecular events activated via the IL-5R is the JAK/STAT signaling pathway.
Caldenhoven, Eric, Dijk, Thamar B. van, Raaijmakers, J.A.M., Lammers, J.W.J., Koenderman, L., Groot, Rolf P. de   +5 more
openaire   +3 more sources

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner

Neoplasia: An International Journal for Oncology Research, 2015
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. Here
Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V. Mohrenz, Volker Seifert, Achim Aigner, Donat Kögel   +6 more
doaj   +1 more source

Prediction and experimental validation of novel STAT3 target genes in human cancer cells. [PDF]

PLoS ONE, 2009
The comprehensive identification of functional transcription factor binding sites (TFBSs) is an important step in understanding complex transcriptional regulatory networks.
Young Min Oh, Jong Kyoung Kim, Yongwook Choi, Seungjin Choi, Joo-Yeon Yoo   +4 more
doaj   +1 more source

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Frontiers in Immunology, 2018
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes.
Elissa K. Deenick, Elissa K. Deenick, Simon J. Pelham, Simon J. Pelham, Alisa Kane, Alisa Kane, Alisa Kane, Alisa Kane, Cindy S. Ma, Cindy S. Ma   +9 more
doaj   +1 more source