Neoplasia: An International Journal for Oncology Research, 2015 The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. Here
Irina Kiprianova +6 more
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Prediction and experimental validation of novel STAT3 target genes in human cancer cells. [PDF]
PLoS ONE, 2009 The comprehensive identification of functional transcription factor binding sites (TFBSs) is an important step in understanding complex transcriptional regulatory networks.
Young Min Oh +4 more
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STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription [PDF]
Journal of Biological Chemistry, 1996 The 89-kDa STAT3 protein is a latent transcription factor which is activated in response to cytokines (interleukin (IL)-5 and -6) and growth factors (epidermal growth factor). Binding of IL-5 to its specific receptor activates JAK2 which leads to the tyrosine phosphorylation of STAT3 proteins.
Caldenhoven, Eric +7 more
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Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses
Frontiers in Immunology, 2018 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes.
Elissa K. Deenick +9 more
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Foxm1 mediates LIF/Stat3-dependent self-renewal in mouse embryonic stem cells and is essential for the generation of induced pluripotent stem cells. [PDF]
PLoS ONE, 2014 Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) is required for maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs).
Guixiang Tan +4 more
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Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
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Targeting STAT3 Signaling Pathway in Colorectal Cancer
Biomedicines, 2021 Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor that has been firmly associated with colorectal cancer (CRC) initiation and development. STAT3 mediates key inflammatory mechanisms in colitis-associated cancer,
Antonios N. Gargalionis +2 more
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Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production [PDF]
, 2017 Signal Transducer and Activator of Transcription 3 (STAT3) has been tied to various physiological and pathological functions, mainly as a transcription factor that translocates to the nucleus upon tyrosine phosphorylation induced by cytokine stimulation.
Ali Raza +30 more
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Архивъ внутренней медицины, 2018 The study discusses the relationship of thiol concentrations in intercellular fluid with the level of peripheral blood mononuclear cells (MNCs) in convalescents with community-acquired pneumonia (CAP) components MAPK/SAPK and JAK/STAT-signaling pathways,
S. S. Bondar +4 more
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STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC ProgressionSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Signal transducer and activator of transcription 3 (STAT3) is known as a pro-oncogenic transcription factor. Regarding liver carcinogenesis, however, it remains controversial whether activated STAT3 is pro- or anti-tumorigenic ...
Yuki Makino +18 more
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