Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency. [PDF]
, 2016 Transcription factor Stat3 directs self-renewal of pluripotent mouse embryonic stem (ES) cells downstream of the cytokine leukemia inhibitory factor (LIF).
Betto, Riccardo M +4 more
core +2 more sources
Identification of novel regulators of STAT3 activity.
PLoS ONE, 2020 STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri +4 more
doaj +1 more source
Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]
, 2019 Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio +14 more
core +1 more source
A model for how signal duration can determine distinct outcomes of gene transcription programs. [PDF]
PLoS ONE, 2012 The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood.
Kevin D Fowler +2 more
doaj +1 more source
Journal of Biological Chemistry, 2010 The STAT3 transcription factors are cytoplasmic proteins that induce gene activation in response to growth factor stimulation. Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes ...
Sandy Courapied +7 more
semanticscholar +1 more source
STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]
, 2010 The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan +2 more
core +2 more sources
STAT3 plays an important role in DNA replication by turning on WDHD1
Cell & Bioscience, 2021 Background Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that plays a key role in many cellular processes such as cell growth and cancer.
Yunying Zhou, Jason J. Chen
doaj +1 more source
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]
, 2012 Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P. +19 more
core +2 more sources