Results 11 to 20 of about 273,588 (361)
STAT3 pathway in cancers: Past, present, and future
MedComm, 2022 Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family, discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in biological functions.
Han-Qi Wang, Lin-Lin Bu
exaly +2 more sources
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
Nature Reviews Clinical Oncology, 2018 The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis.
Daniel E Johnson +2 more
exaly +2 more sources
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Cancer Cell, 2019 Summary Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. We report herein the discovery of SD-36, a small-molecule degrader of STAT3.
Longchuan Bai +2 more
exaly +2 more sources
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
International Journal of Molecular Sciences, 2021 Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types of tumors and depends on mechanisms such as hyperactivation of receptors ...
Manlio Tolomeo, Antonio Cascio
exaly +2 more sources
Cell, 1999 STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances transformation, or blocks apoptosis.
Jacqueline F. Bromberg +6 more
semanticscholar +4 more sources
STAT3 signaling in immunity [PDF]
Cytokine & Growth Factor Reviews, 2016 The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity.
E. Hillmer +3 more
semanticscholar +3 more sources
Gut and Liver, 2021 Background/Aims: Interleukin-22 (IL-22) is an important cytokine maintaining homeostasis at barrier surfaces. In this study, the role of IL-22 in acute pancreatitis-associated intestinal injury was further explored.
Jinxia Bai, Jinyun Bai, Meng Yang
doaj +1 more source
Advances in the role of STAT3 in macrophage polarization
Frontiers in Immunology, 2023 The physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has an impact on the onset and progression of a number of inflammatory ...
T. Xia +7 more
semanticscholar +1 more source
Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
Frontiers in Pharmacology, 2022 Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target stability (DARTS), and fluorescence polarization (FP) assays altogether determined that 323–1 and 323–2 directly target the STAT3 SH2 ...
Yaping Hua +19 more
openaire +6 more sources
Redox Biology, 2022 Chemotherapy is still one of the principal treatments for gastric cancer, but the clinical application of 5-FU is limited by drug resistance. Here, we demonstrate that ferroptosis triggered by STAT3 inhibition may provide a novel opportunity to explore a
Shumin Ouyang +19 more
semanticscholar +1 more source