Results 41 to 50 of about 229,822 (315)

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Disease Models & Mechanisms, 2020
Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured.
Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto   +3 more
doaj   +1 more source

Daucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6/STAT3 signaling pathway

Cancer Biology & Therapy, 2023
Daucosterol is a phytosterol glycoside with hepatoprotective properties. The objective of the present study was to confirm the role of daucosterol in liver failure. Exosomes were isolated from primary mouse umbilical cord mesenchymal stem cells (UCMSCs).
Changqing Deng, Jia Hu, Ling He, Laian Ge, Na Wu, Mingjun Xie, Xiaojuan Yang, Chuncheng Wu, Qin Liu   +8 more
doaj   +1 more source

Differential silencing of STAT3 isoforms leads to changes in STAT3 activation

Oncotarget, 2023
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in multiple fundamental biological processes and a key player in cancer development and progression. STAT3 is activated upon tyrosine phosphorylation and is constitutively active in various malignancies; therefore, the expression of pSTAT3 has been recognized ...
Shamir, Inbal, Tsarfaty, Ilan, Paret, Gidi, Nevo-Caspi, Yael   +3 more
openaire   +2 more sources

Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer [PDF]

, 2007
The main cause of prostate cancer-related mortality is the development of hormone-refractory disease. Circulating serum levels of IL-6 are raised in hormone-refractory prostate cancer patients and evidence from cell line studies suggests that the IL-6R ...
Tam, L., Traynor, P., P Traynor, McGlynn, L.M., L Tam, Mukherjee, R., J M S Bartlett, J Edwards, Bartlett, J.M.S., Edwards, J., L M McGlynn, R Mukherjee   +11 more
core   +1 more source

Flurbiprofen ameliorates glucose deprivation-induced leptin resistance

Frontiers in Pharmacology, 2016
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi, Yuka Suyama, Takaaki Kayano, Koichiro Ozawa   +3 more
doaj   +1 more source

Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway

Frontiers in Pharmacology, 2021
Background and objective: Abnormal activation of Janus kinase 2 (JAK2) promotes the pathogenesis and progress of inflammatory bowel disease (IBD) by stimulating the cytokine traffic.
Liang Wang, Liang Wang, Yuntao Feng, Jianwen Wang, Tenglong Luo, Xinyue Wang, Mengze Wu, Runxia Wang, Dapeng Chen, Jiyan Li, Jingyu Wang   +10 more
doaj   +1 more source

Table_1_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

OncoImmunology, 2018
Exosomes can mediate a dynamic method of communication between malignancies, including those sequestered in the central nervous system and the immune system.
Konrad Gabrusiewicz, Xu Li, Jun Wei, Yuuri Hashimoto, Anantha L. Marisetty, Martina Ott, Fei Wang, David Hawke, John Yu, Luke M. Healy, Anwar Hossain, Johnny C. Akers, Sourindra N. Maiti, Shinji Yamashita, Yuzaburo Shimizu, Kenneth Dunner, M. Anna Zal, Jared K. Burks, Joy Gumin, Felix Nwajei, Aras Rezavanian, Shouhao Zhou, Ganesh Rao, Raymond Sawaya, Gregory N. Fuller, Jason T. Huse, Jack P. Antel, Shulin Li, Laurence Cooper, Erik P. Sulman, Clark Chen, Changiz Geula, Raghu Kalluri, Tomasz Zal, Amy B. Heimberger   +34 more
doaj   +1 more source

STAT3 single nucleotide polymorphism rs4796793 SNP does not correlate with response to adjuvant IFNα therapy in stage III melanoma patients

Frontiers in Medicine, 2014
Interferon alpha (IFNα) is approved for adjuvant treatment of stage III melanoma in Europe and the US. Its clinical efficacy, however, is restricted to a subpopulation of patients while side effects occur in most of treated patients.
David eSchrama, Selma eUgurel, Antje eSucker, Cathrin eRitter, Cathrin eRitter, Marc eZapatka, Dirk eSchadendorf, Juergen Christian Becker, Juergen Christian Becker, Juergen Christian Becker   +9 more
doaj   +1 more source

Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

OncoImmunology, 2020
Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, it is vital to understand the ...
Mara De Martino, Mercedes Tkach, Sofía Bruni, Darío Rocha, María F. Mercogliano, Mauro E. Cenciarini, María F. Chervo, Cecilia J. Proietti, Florent Dingli, Damarys Loew, Elmer A. Fernández, Patricia V. Elizalde, Eliane Piaggio, Roxana Schillaci   +13 more
doaj   +1 more source