Results 41 to 50 of about 273,588 (361)
Frontiers in Medicine, 2021 The aim of the present study was to investigate the effect of erythropoietin (EPO) on contrast-induced nephrology (CIN) in vivo and in vitro. Male C57BL/6J mice were divided into four groups: control, CIN (iohexol 6.0 g/kg), EPO (3,000 IU/kg), and CIN ...
Jia Yang +6 more
doaj +1 more source
Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]
, 2014 Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S. +32 more
core +1 more source
Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1
Frontiers in Pharmacology, 2016 Sphingosine 1-phosphate (S1P) is an immune modulatory lipid mediator and has been implicated in numerous pathophysiological processes. S1P is produced by sphingosine kinase 1 (Sphk1) and Sphk2.
Anja eSchwiebs +5 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a major NADH ...
Cuiyan Zhou +5 more
doaj +1 more source
Blood, 2021 AML is characterized by the presence of leukemia stem cells (LSCs), and failure to fully eradicate this population contributes to disease persistence/relapse.
M. Amaya +14 more
semanticscholar +1 more source
T cell activation or tolerization: the Yin and Yang of bacterial superantigens
Frontiers in Microbiology, 2015 Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr +3 more
doaj +1 more source
Cancer Cell, 2009 Summary Colitis associated cancer (CAC) is the most serious complication of inflammatory bowel disease. Pro-inflammatory cytokines were suggested to regulate pre-neoplastic growth during CAC tumorigenesis.
S. Grivennikov +10 more
semanticscholar +1 more source
A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis
Nature, 2020 Cysteine palmitoylation (S-palmitoylation) is a reversible post-translational modification that is installed by the DHHC family of palmitoyltransferases and is reversed by several acyl protein thioesterases1,2.
Mingming Zhang +11 more
semanticscholar +1 more source
Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer [PDF]
, 2007 The main cause of prostate cancer-related mortality is the development of hormone-refractory disease. Circulating serum levels of IL-6 are raised in hormone-refractory prostate cancer patients and evidence from cell line studies suggests that the IL-6R ...
Tam, L. +11 more
core +1 more source
The R(h)oads to Stat3: Stat3 activation by the Rho GTPases [PDF]
Experimental Cell Research, 2011 The signal transducer and activator of transcription-3 (Stat3) is a member of the STAT family of cytoplasmic transcription factors. Overactivation of Stat3 is detected with high frequency in human cancer and is considered a molecular abnormality that supports the tumor phenotype. Despite concerted investigative efforts, the molecular mechanisms leading
Raptis, Leda +3 more
openaire +3 more sources