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IL6-STAT3-HSP90 signaling axis mediates temperature dependency of GCRV infection.

, 2023
(A) CIK cells transfected with different doses of STAT3-C plasmids were prepared to quantify the relative expression of IL6, IL1β, and TNF-α by RT-PCR analysis.
Rui Song (331963) +13 more
core +1 more source

Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation

, 2017
Although cytokine-driven STAT3 phosphorylation and activation are often transient, persistent activation of STAT3 is a hallmark of a range of pathologies and underpins altered transcriptional responses.
林琬琬 +1 more
core +1 more source

Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer [PDF]

, 2022
openIl Signal Transducer And Activator Of Transcription 3 (STAT3) è un fattore di trascrizione che si è dimostrato avere un potenziale oncogeno in diversi tipi tumorali agendo come fattore di trascrizione nucleare dopo aver subito fosforilazione della ...
SCAVEZZON, MATTEO
core

IL6-STAT3-HSP90 axis mediates viral entry in aquatic ectotherms.

, 2023
(A) Evolutionary conserveness analysis of STAT3 was conducted by multiple amino acids alignment of STAT3 from different species. The phosphorylation residue tyrosine 705 (Y705) which mediates the canonical STAT3 activation was highlighted in bold with ...
Rui Song (331963) +13 more
core +1 more source

Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities

Journal of Innate Immunity
Introduction: Signal transducer and activator of transcription (STAT) 3 is extensively involved in the development, homeostasis, and function of immune cells, with STAT3 disruption associated with human immune-related disorders.
Mohamed Luban Sobah, Clifford Liongue, Alister C. Ward +2 more
doaj +1 more source

ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling

FEBS Letters, 2013
STAT3 physically interacts with ECHS1 by anti bait co immunoprecipitation (View interaction)
Chang, Yan +10 more
openaire +2 more sources

Stat3 beta mitigates development of atherosclerosis in apolipoprotein E-deficient mice

, 2014
The transcription factor Stat3 is an activator of systemic inflammatory genes. Two isoforms of Stat3 are generated by alternative splicing, Stat3 alpha and Stat3 beta.
李志元 +1 more
core +1 more source

Table_8_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671) +12 more
core +1 more source

Table_6_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671) +12 more
core +1 more source

ZFAS1/STAT3 axis modulates imatinib resistance of chronic myeloid leukemia cells through glucose metabolism reprogramming

Frontiers in Oncology
BackgroundChronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (chromosome 22). This cytogenetic abnormality gives rise to the BCR::ABL1 fusion gene, which encodes the constitutively
Lan Yang, Yanqiu Han
doaj +1 more source

humans
stat3 transcription factor
animals

3. good health
signal transduction
neoplasms

b2
apoptosis
a1