Results 51 to 60 of about 294,427 (307)
Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway
Frontiers in Pharmacology, 2021 Background and objective: Abnormal activation of Janus kinase 2 (JAK2) promotes the pathogenesis and progress of inflammatory bowel disease (IBD) by stimulating the cytokine traffic.
Liang Wang +10 more
doaj +1 more source
The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]
, 2010 The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan +2 more
core +2 more sources
Psoriasis: A STAT3-Centric View [PDF]
International Journal of Molecular Sciences, 2018 Signal Transducer and Activator of Transcription (STAT)3 has recently emerged as a key player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory conditions. Indeed, STAT3 hyperactivation has been reported in virtually every cell type involved in disease initiation and maintenance, and this factor mediates the signal of ...
Calautti, Enzo +2 more
openaire +4 more sources
OncoImmunology, 2018 Exosomes can mediate a dynamic method of communication between malignancies, including those sequestered in the central nervous system and the immune system.
Konrad Gabrusiewicz +34 more
doaj +1 more source
Frontiers in Medicine, 2014 Interferon alpha (IFNα) is approved for adjuvant treatment of stage III melanoma in Europe and the US. Its clinical efficacy, however, is restricted to a subpopulation of patients while side effects occur in most of treated patients.
David eSchrama +9 more
doaj +1 more source
OncoImmunology, 2020 Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, it is vital to understand the ...
Mara De Martino +13 more
doaj +1 more source
Journal of Innate ImmunityIntroduction: Signal transducer and activator of transcription (STAT) 3 is extensively involved in the development, homeostasis, and function of immune cells, with STAT3 disruption associated with human immune-related disorders.
Mohamed Luban Sobah +2 more
doaj +1 more source
Differential silencing of STAT3 isoforms leads to changes in STAT3 activation
Oncotarget, 2023 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in multiple fundamental biological processes and a key player in cancer development and progression. STAT3 is activated upon tyrosine phosphorylation and is constitutively active in various malignancies; therefore, the expression of pSTAT3 has been recognized ...
Shamir, Inbal +3 more
openaire +2 more sources
Sakarya Tıp Dergisi, 2022 Amaç: Tamoksifen östrojen reseptörlerine seçici bir şekilde bağlanarak anti-östrojenik etki gösteren ve östrojen reseptörü pozitif (ER+) meme kanseri hastalarının endokrin tedavisinde kullanılan bir ajandır.
Gamze Güney Eskiler +4 more
doaj +1 more source
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours [PDF]
, 2015 Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy.
Alajati, Abdullah +25 more
core +1 more source