Results 51 to 60 of about 273,588 (361)

Opposite effects of a high-fat diet and calorie restriction on ciliary neurotrophic factor signalling in the mouse hypothalamus

Frontiers in Neuroscience, 2013
In the mouse hypothalamus, ciliary neurotrophic factor (CNTF) is mainly expressed by ependymal cells and tanycytes of the ependymal layer covering the third ventricle.
Ilenia eSeveri, Jessica ePerugini, Eleonora eMondini, Arianna eSmorlesi, Andrea eFrontini, Saverio eCinti, Saverio eCinti, Antonio eGiordano   +7 more
doaj   +1 more source

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Disease Models & Mechanisms, 2020
Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured.
Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto   +3 more
doaj   +1 more source

Daucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6/STAT3 signaling pathway

Cancer Biology & Therapy, 2023
Daucosterol is a phytosterol glycoside with hepatoprotective properties. The objective of the present study was to confirm the role of daucosterol in liver failure. Exosomes were isolated from primary mouse umbilical cord mesenchymal stem cells (UCMSCs).
Changqing Deng, Jia Hu, Ling He, Laian Ge, Na Wu, Mingjun Xie, Xiaojuan Yang, Chuncheng Wu, Qin Liu   +8 more
doaj   +1 more source

IL6-STAT3-HSP90 signaling axis mediates temperature dependency of GCRV infection.

, 2023
(A) CIK cells transfected with different doses of STAT3-C plasmids were prepared to quantify the relative expression of IL6, IL1β, and TNF-α by RT-PCR analysis.
Rui Song (331963), Xiaodong Wang (66801), Hongquan Wang (6086327), Wenzhi Liu (3997184), Zhao Lv (3122814), Qiushi Zhang (3812230), Chunhua Ding (832221), Liang Hu (202392), Junhua Li (125998), Shuting Xiong (630639), Tiaoyi Xiao (9162782), Yong-An Zhang (829491), Guoli Hou (11736683), Chun Li (57810)   +13 more
core   +1 more source

ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling

FEBS Letters, 2013
STAT3 physically interacts with ECHS1 by anti bait co immunoprecipitation (View interaction)
Chang, Yan, Wang, Shao-Xin, Wang, Yu-Bo, Zhou, Jie, Li, Wei-Hua, Wang, Na, Fang, Di-Feng, Li, Hui-Yan, Li, Ai-Ling, Zhang, Xue-Min, Zhang, Wei-Na   +10 more
openaire   +2 more sources

Flurbiprofen ameliorates glucose deprivation-induced leptin resistance

Frontiers in Pharmacology, 2016
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi, Yuka Suyama, Takaaki Kayano, Koichiro Ozawa   +3 more
doaj   +1 more source

Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway

Frontiers in Pharmacology, 2021
Background and objective: Abnormal activation of Janus kinase 2 (JAK2) promotes the pathogenesis and progress of inflammatory bowel disease (IBD) by stimulating the cytokine traffic.
Liang Wang, Liang Wang, Yuntao Feng, Jianwen Wang, Tenglong Luo, Xinyue Wang, Mengze Wu, Runxia Wang, Dapeng Chen, Jiyan Li, Jingyu Wang   +10 more
doaj   +1 more source

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

Neoplasia, 2021
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of genes
I. Tošić, D. Frank
semanticscholar   +1 more source

IL6-STAT3-HSP90 axis mediates viral entry in aquatic ectotherms.

, 2023
(A) Evolutionary conserveness analysis of STAT3 was conducted by multiple amino acids alignment of STAT3 from different species. The phosphorylation residue tyrosine 705 (Y705) which mediates the canonical STAT3 activation was highlighted in bold with ...
Rui Song (331963), Xiaodong Wang (66801), Hongquan Wang (6086327), Wenzhi Liu (3997184), Zhao Lv (3122814), Qiushi Zhang (3812230), Chunhua Ding (832221), Liang Hu (202392), Junhua Li (125998), Shuting Xiong (630639), Tiaoyi Xiao (9162782), Yong-An Zhang (829491), Guoli Hou (11736683), Chun Li (57810)   +13 more
core   +1 more source

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors [PDF]

Nature Medicine, 2010
Interleukin-6 (IL-6)-Janus kinase (JAK) signaling is viewed as crucial for persistent signal transducer and activator of transcription-3 (STAT3) activation in cancer. However, IL-6-induced STAT3 activation is normally transient. Here we identify a key mechanism for persistent STAT3 activation in tumor cells and the tumor microenvironment.
Lee, Heehyoung, Deng, Jiehui, Kujawski, Maciej, Yang, Chunmei, Liu, Yong, Herrmann, Andreas, Kortylewski, Marcin, Horne, David, Somlo, George, Forman, Stephen, Jove, Richard, Yu, Hua   +11 more
openaire   +2 more sources