Results 71 to 80 of about 273,588 (361)

STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis

Nature Communications, 2021
Skeletal deformities are typical AD-HIES manifestations, which are mainly caused by heterozygous and loss-of-function mutations in Signal transducer and activator of transcription 3 (STAT3).
Siru Zhou, Q. Dai, Xiangru Huang, A. Jin, Yiling Yang, X. Gong, Hongyuan Xu, Xin Gao, Lingyong Jiang   +8 more
semanticscholar   +1 more source

Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation

, 2017
Although cytokine-driven STAT3 phosphorylation and activation are often transient, persistent activation of STAT3 is a hallmark of a range of pathologies and underpins altered transcriptional responses.
林琬琬, Huang, Chen-Tsung;Huang, Duen-Yi;Hu, Chaur-Jong;Wu, Dean;Lin, Wan-Wan   +1 more
core   +1 more source

Table_7_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Targeting STAT3 Signaling Pathway in Colorectal Cancer

Biomedicines, 2021
Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor that has been firmly associated with colorectal cancer (CRC) initiation and development. STAT3 mediates key inflammatory mechanisms in colitis-associated cancer,
A. Gargalionis, K. Papavassiliou, A. Papavassiliou   +2 more
semanticscholar   +1 more source

Data_Sheet_1_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.PDF

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

ZFAS1/STAT3 axis modulates imatinib resistance of chronic myeloid leukemia cells through glucose metabolism reprogramming

Frontiers in Oncology
BackgroundChronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (chromosome 22). This cytogenetic abnormality gives rise to the BCR::ABL1 fusion gene, which encodes the constitutively
Lan Yang, Yanqiu Han
doaj   +1 more source

Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach

Frontiers in Pharmacology, 2022
The rapid growth of vascular smooth muscle cells (VSMCs) represents crucial pathological changes during the development of hypertensive vascular remodeling. Although quercetin exhibits significantly therapeutic effects on antihypertension, the systematic
Di Wang, Di Wang, Di Wang, Farman Ali, Farman Ali, Farman Ali, Huixin Liu, Huixin Liu, Huixin Liu, Ying Cheng, Ying Cheng, Ying Cheng, Meizhu Wu, Meizhu Wu, Meizhu Wu, Muhammad Zubair Saleem, Huifang Zheng, Huifang Zheng, Huifang Zheng, Lihui Wei, Lihui Wei, Lihui Wei, Jiangfeng Chu, Jiangfeng Chu, Jiangfeng Chu, Qiurong Xie, Qiurong Xie, Qiurong Xie, Aling Shen, Aling Shen, Aling Shen, Jun Peng, Jun Peng, Jun Peng   +33 more
doaj   +1 more source

IL6/STAT3 signaling hijacks ER enhancers to drive breast cancer metastasis

Cancer Cell, 2020
Summary The cytokine interleukin 6 (IL6) and its downstream effector STAT3 constitute a key oncogenic pathway, which has been thought to be functionally connected to estrogen receptor α (ER) in breast cancer.
Rasmus Siersbæk, Valentina Scabia, S. Nagarajan, I. Chernukhin, Evangelia K. Papachristou, R. Broome, S. Johnston, Stacey E. P. Joosten, A. Green, Sanjeev Kumar, Julia Jones, Soleilmane Omarjee, R. Alvarez-Fernandez, Silvia-Elena Glont, Sarah J. Aitken, K. Kishore, D. Cheeseman, E. Rakha, C. D’Santos, W. Zwart, Alasdair Russell, C. Brisken, J. Carroll   +22 more
semanticscholar   +1 more source

STAT3-dependent upregulation of IGF2 in TSC2-null cells.

, 2018
(A) Re-expression of TSC2 (TSC2++) in TSC2-null LAM 102 (TSC2—) cells decreased STAT3 expression and activation. (B) siRNA-induced knockdown of STAT3 decreased STAT3 levels in TSC2— cells.
Maya Shumyatcher (5215781), Stella K. Hur (4875787), Vera P. Krymskaya (188111), Ryan Rue (5215775), Blanca E. Himes (153105), Lurong Lian (436174), Marisa S. Bartolomei (328035), Kseniya Obraztsova (5215778), Elena N. Atochina-Vasserman (511732), Jilly F. Evans (2138905)   +9 more
core   +1 more source

Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury

Frontiers in Immunology
IntroductionNaringenin (Nar), a common flavanone abundant in citrus fruits and tomatoes, is common in diets. Although Nar can alleviate intestinal ischemia/reperfusion injury (IRI), the exact anti-inflammatory mechanisms are unclear and require further ...
Min Hou, Yanshun Wang, Suheng Chen, Zhiguo Tan, Jie Liu, Xiaoxi Li, Xiaoxia Han, Zaiqi Yang, Yufang Leng, Yufang Leng   +9 more
doaj   +1 more source