Results 91 to 100 of about 273,588 (361)

Table_3_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Perspective: mitochondrial STAT3 in cardioprotection

Basic Research in Cardiology, 2023
AbstractActivation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key cardioprotective signal not only in animal studies but also in humans—in animals, STAT3 is causally involved in cardioprotection. In response to late ischemic conditioning, canonical function of STAT3 activation upregulates the expression of ...
openaire   +3 more sources

Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity [PDF]

Molecular and Cellular Biology, 2015
The transcription factor STAT3 is constitutively active in many cancers, where it mediates important biological effects, including cell proliferation, differentiation, survival, and angiogenesis. The N-terminal domain (NTD) of STAT3 performs multiple functions, such as cooperative DNA binding, nuclear translocation, and protein-protein interactions ...
Tiancen, Hu, Jennifer E, Yeh, Luca, Pinello, Jaison, Jacob, Srinivas, Chakravarthy, Guo-Cheng, Yuan, Rajiv, Chopra, David A, Frank   +7 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Aberrant RET expression affects normal mammary gland post-lactation transition, enhancing cancer potential

Disease Models & Mechanisms, 2022
RET is a receptor tyrosine kinase with oncogenic potential in the mammary epithelium. Several receptors with oncogenic activity in the breast are known to participate in specific developmental stages.
Sabrina A. Vallone, Martín García Solá, Carolina Schere-Levy, Roberto P. Meiss, Gladys N. Hermida, Lewis A. Chodosh, Edith C. Kordon, Nancy E. Hynes, Albana Gattelli   +8 more
doaj   +1 more source

STRA13 Interacts with STAT3 and Modulates Transcription of STAT3-dependent Targets

Journal of Molecular Biology, 2004
STRA13 is a pVHL-dependent bHLH transcription factor up-regulated on the mRNA level in multiple cancer cell lines and implicated recently in the regulation of immune cell homeostasis and autoimmunity. In searching for STRA13-interacting proteins with oncogenic potential by the yeast two-hybrid screening, we identified STAT3β as a STRA13-binding partner.
Ivanov, Vladimir N., Ivanova, A. V., Ivanov, S. V., Zhang, X., Timofeeva, O. A., Lerman, M. I.   +5 more
openaire   +4 more sources

Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function [PDF]

Journal of Biological Chemistry, 2008
To explore the basis of metastasis, we compared the human breast cancer lines MCF-7 and MDA-MB453, which have low invasive ability, with their sublines MCF7-I4 and MDA-MB453-I4 with high invasive ability for gene expression and signaling pathways. We previously showed that the I4 lines had dramatically elevated levels of Twist compared with their ...
George Z, Cheng, Wei Zhou, Zhang, Mei, Sun, Qi, Wang, Domenico, Coppola, Mena, Mansour, Li Mei, Xu, Carliann, Costanzo, Jin Q, Cheng, Lu-Hai, Wang   +9 more
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

STAT3 Suppresses Cardiomyocytes Apoptosis in CVB3-Induced Myocarditis Via Survivin

Frontiers in Pharmacology, 2021
Background: Viral myocarditis (VMC) is a common inflammatory cardiovascular disease with unclear mechanisms, which mainly affects children and adolescents.
Qiaoyu Wang, Qiongjun Zhu, Qiaofang Ye, Jiajun Wang, Qianqian Dong, Youran Chen, Minna Wang, Yu Fu, Rongzhou Wu, Tingting Wu   +9 more
doaj   +1 more source

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.

Cell, 1995
Stat1 and Stat3 are latent transcriptional factors activated initially through phosphorylation on single tyrosine residues induced by cytokine and growth factor occupation of cell surface receptors.
Zilong Wen, Z. Zhong, J. Darnell
semanticscholar   +1 more source